Abstract：
INTRODUCTION:The term spitzoid melanoma (SM) is reserved for a rare group of tumors with striking resemblance to Spitz nevus, often developing in children diagnosed in retrospect after the development of metastases. OBJECTIVES:To determine the biological significance of SM and to analyze the effectiveness of adjuvant diagnostic techniques. MATERIALS AND METHODS:A retrospective, observational study of 38 cases of SM in patients younger than 18 years. Histological type, Clark level and Breslow thickness, radial and vertical growth phase, mitotic count/mm(2), ulceration, regression, vascular and perineural invasion, satellitosis, cytology and associated nevi were reviewed. An immunohistochemical analysis with HMB45 and Ki67 was performed in 10 cases. These features were correlated to patient's stage and outcome. RESULTS:Analysis of histological and immunohistochemical features should allow accurate diagnosis in most cases. Given the low mortality rate, no conclusions about the prognostic significance of histological parameters of the primary tumor could be established. CONCLUSION:We report the largest series of SM from a unique center. Although these patients may have a better prognosis than adults, some patients with SM develop metastasis and die, particularly after age 11 years. Therefore, we recommend using the same treatments as in adults.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Paradela S,Fonseca E,Pita S,Kantrow SM,Goncharuk VN,Diwan H,Prieto VGdoi
10.1111/j.1600-0560.2008.01153.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
740-52issue
7eissn
0303-6987issn
1600-0560pii
CUP1153journal_volume
36pub_type
杂志文章abstract：:Cutaneous CD30+ lymphoid infiltrates appear cytologically atypical and occasionally may be misinterpreted as recurrent disease when they occur in patients treated for other primary hematologic malignancies. We recently encountered two such cases and present our findings. One patient with B-cell lymphoma and another wi...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2000.027005249.x
更新日期：2000-05-01 00:00:00
abstract：:Cutaneous mixed tumors (MTs), also known as chondroid syringomas, usually arise as small nodules in the head and neck region. We describe an unusual case of a giant MT measuring 9 cm in its greatest diameter, occurring as a slowly growing pedunculated mass on the breast of a 74-year-old woman. Although MT may rarely o...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2008.01104.x
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Infection with parvovirus B19 (B19) has been associated with connective tissue disease (CTD) stigmata, namely, a systemic lupus erythematosus (SLE)-like illness, seronegative polyarthritis resembling rheumatoid arthritis, and vasculitis. The dermatopathology and pathogenetic basis of such B19-associated CTD-...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2000.027010505.x
更新日期：2000-11-01 00:00:00
abstract：:The characteristic histologic change seen at 2 h in the Rumpel-Leede (Hess) test is, in addition to focal hemorrhage in the upper dermis, a perivascular lymphocyte infiltrate with focal areas of lymphocytic epidermal invasion. The histologic findings, even with the liquefaction degeneration, are similar to those of pu...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1979.tb00300.x
更新日期：1979-02-01 00:00:00
abstract：:In past years, association of primary cutaneous B-cell lymphoma (CBCL) with infection by Borrelia burgdorferi has been reported in a few patients. The evidence for a pathogenetic role was based on clinical grounds or raised titre of antibodies in serum. Both methods, however, do not prove the association between the m...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1997.tb01318.x
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Glial cell line-derived neurotrophic factor (GDNF) and a related family member, neurturin (NTN), as well as their cognate receptors (GDNF receptors, GFRalpha-1 and GFRalpha-2, respectively) are involved in nervous system development and murine hair cycle control. To date, their expression in human scalp skin...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00561.x
更新日期：2006-12-01 00:00:00
abstract：:Basic fibroblast growth factor (bFGF) is a growth factor and an angiogenesis factor which may play a role in the evolution of cutaneous malignant melanoma (CMM). In this study, we evaluated the distribution of bFGF in CMM using immunochemical methods and correlated the pattern of bFGF expression with the clinical cour...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1996.tb01442.x
更新日期：1996-12-01 00:00:00
abstract：:We encountered a patient who complained of many small papules on the neck, shoulders, upper chest and upper back. Biopsy specimens showed complete loss of elastic fibers in the upper dermis including papillary dermis, whereas those of the mid dermis were intact. Electron microscopy revealed that assembly of component ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1994.tb00724.x
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:p16 immunostaining has been used to aid and improve the histopathologic evaluation of equivocal cervical lesions with associated low-grade or high-grade dysplasia. However, the utility of p16 immunostaining in the diagnosis of atypical genital skin lesions remains debatable. METHODS:We conducted a cross-sec...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12525
更新日期：2015-08-01 00:00:00
abstract：:The advent of immunoperoxidase technique on paraffin embedded tissue has identified a number of shared immunologic markers present in various lymphoproliferative cutaneous disorders. Two such disorders are the recently described primary cutaneous CD30-positive anaplastic large cell lymphoma (ALCL) and lymphomatoid pap...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1995.tb01413.x
更新日期：1995-08-01 00:00:00
abstract：:Proliferation of the eccrine sweat duct epithelium has been associated with skin tumors, especially keratoacanthomas and basal cell carcinomas. We report our observations on the extensive sweat gland changes in a patient who had idiopathic follicular mucinosis. ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1987.tb00495.x
更新日期：1987-06-01 00:00:00
abstract：BACKGROUND:The histopathologic findings of localized reactions to tick bites may present as diagnostic dilemmas, especially if there is no history of a tick bite, or if the tick's mouthparts are not present in the biopsied skin. OBJECTIVE:Skin biopsies of patients with a clinical history of a tick bite were selected a...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2001.290207.x
更新日期：2002-02-01 00:00:00
abstract：:Imiquimod (AldaraTM), a Toll-like receptor 7 agonist (TLR7), is known for its unique properties of being an immune response modifier and stimulator. Upon topical application, this TLR7 agonist triggers a cell-mediated immune response predominantly expressed by dendritic cells and monocytes. Local skin irritation at th...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2010.01592.x
更新日期：2011-04-01 00:00:00
abstract：:Serum amyloid P component (SAP) is present not only in all types of cutaneous amyloidosis, but also in the normal dermal elastic fibers as well as abnormal elastic fibers, such as elastotic degeneration of elastic fibers in actinic keratosis. It was previously postulated that the colloid substance in colloid milium is...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1985.tb01616.x
更新日期：1985-04-01 00:00:00
abstract：:Sarcoidosis is a granulomatous condition with diverse clinical presentations, including neurological findings. It was previously hypothesized that perineural sarcoidal granulomas in the skin may be an explanation of small-fiber neuropathy. Herein, we present a case of a 55 year old female with anesthetic cutaneous les...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13660
更新日期：2020-07-01 00:00:00
abstract：:Subungual melanoma commonly presents with solitary longitudinal melanonychia. Herein, we report the case of a patient with subungual melanoma who developed involvement of three digits by three independent primary melanomas. A 98-year-old male patient presented with a two-year history of longitudinal melanonychia on th...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2011.01799.x
更新日期：2012-02-01 00:00:00
abstract：:A survey of conditions with mucinous deposits is given. The most important factors for their diagnosis are to consider these disorders and to stain the slides for proteoglycans or glycosaminoglycans; the most common routine techniques are the Giemsa and the Alcian-blue stain. More sophisticated methods allow different...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1985.tb01637.x
更新日期：1985-06-01 00:00:00
abstract：:Verrucous hemangioma represents a rare congenital vascular proliferation that may be mistaken for angiokeratoma. Histopathological examination of a deep biopsy is necessary to confirm the diagnosis of verrucous hemangioma based on its involvement of the deep dermis and subcutaneous tissue. We present two cases of verr...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.2011.01733.x
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Cryptococcosis and alternariosis are rare opportunistic infections often observed in immunocompromised patients. Because Cryptococcus and Alternaria are ubiquitous fungi found in soil, the presence of fungi in the dermis has to be observed on histological examination to confirm a real cutaneous, invasive, in...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1046/j.0303-6987.2001.00035.x
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Nickel can induce cellular and nuclear damages responsible for chronic diseases, like allergic contact dermatitis (ACD). We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). OBJECTIVE:To investigate the si...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00647.x
更新日期：2007-06-01 00:00:00
abstract：:A 54-year-old female presented with the cutaneous metastases of the breast carcinoma that produced combination of pigmented zosteriform eruption on the trunk and eroded plaque on the scalp, 13 years after radical mastectomy. Histologically, zosteriform lesions displayed prominent infiltration of the epidermis in nesti...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2003.00130.x
更新日期：2003-11-01 00:00:00
abstract：:To explore the clinicopathological features of a rare dedifferentiated liposarcoma (DDLPS) with meningothelial-like whorls, we retrospectively analyzed 46 reported cases and 1 case that we encountered. Fluorescence in situ hybridization (FISH) analysis of the MDM2 amplification status of our case was also performed. O...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13621
更新日期：2020-02-01 00:00:00
abstract：:Confocal laser scanning microscopy (CLSM) is a new optical microscopic technique, which offers significant advantages over conventional microscopy. CLSM is microscopy of optical sections. Light, which is emitted from regions other than the focal plane, is cut off by introducing a diaphragm in the beam path. The result...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.1995.tb00747.x
更新日期：1995-06-01 00:00:00
abstract：:Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed significant therapeutic benefit in patients with clinically advanced solid malignancies, including melanoma. However, immune-related adverse events (irAE) ar...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13150
更新日期：2018-07-01 00:00:00
abstract：:Peristomal ulcer with cutaneous intestinal metaplasia, defined by scattered colonic crypts within variably intact epidermis, is an exceedingly rare pathologic diagnosis, which possesses the potential to progress to primary adenocarcinoma. Herein, we report the third case of cutaneous intestinal metaplasia in a peristo...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13631
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:The diagnosis of tuberculoid leprosy is often difficult on hematoxylin and eosin (H&E) due to the absence of demonstrable nerve destruction. This study evaluates the utility of S-100 staining in identifying nerve fragmentation and differentiation of tuberculoid leprosy from other cutaneous granulomatous dise...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00457.x
更新日期：2006-07-01 00:00:00
abstract：:Dermatomyositis, a connective tissue disease syndrome where antibodies to the endothelium of the microvasculature of the skin, muscle and lung are implicated in lesional propagation, is characterized by photodistributed erythema, heliotrope rash, Gottron's papules, muscle weakness and interstitial pulmonary fibrosis. ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2007.00767.x
更新日期：2008-01-01 00:00:00
abstract：:We report a rare case of multiple, co-exisitng verruciform xanthomas (VXs) of the anogenital region in the setting of cutaneous trauma. VX is a rare benign mucocutaneous neoplasm that typically presents as a solitary lesion with a predilection for the oral cavity, although extra-oral lesions have been reported involvi...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01470.x
更新日期：2010-08-01 00:00:00
abstract：:Traditionally, the pigmented purpuric eruptions (PPE) have been subdivided into four histologic categories, based upon variations in histologic pattern and clinical morphologies. In recent years, it has become apparent that the lesions behave similarly, and this family of eruptions has become grouped under the term PP...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1991.tb01378.x
更新日期：1991-12-01 00:00:00
abstract：:Herpetic syringitis has been described as a rare manifestation of herpes virus infection in patients with an immunodeficiency, usually secondary to human immunodeficiency virus (HIV) infection. Eccrine squamous syringometaplasia (ESS) is an infrequent alteration of the eccrine duct epithelium reported in association w...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1997.tb00817.x
更新日期：1997-08-01 00:00:00
