Sarcoidosis with cutaneous perineural granulomas and neurological manifestations: A potential mimicker of leprosy.

Abstract:

:Sarcoidosis is a granulomatous condition with diverse clinical presentations, including neurological findings. It was previously hypothesized that perineural sarcoidal granulomas in the skin may be an explanation of small-fiber neuropathy. Herein, we present a case of a 55 year old female with anesthetic cutaneous lesions mimicking leprosy clinically and histopathologically and discuss the importance of this differential diagnosis.

journal_name

J Cutan Pathol

authors

Kazi R,Kazlouskaya V,Ho J,Karunamurthy A

doi

10.1111/cup.13660

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

625-627

issue

7

eissn

0303-6987

issn

1600-0560

journal_volume

47

pub_type

  • ICAM-3 and E-selectin endothelial cell expression differentiate two phases of angiogenesis in infantile hemangiomas.

    abstract::Cellular adhesion molecules are newly identified mediators of angiogenesis. Infantile hemangiomas, characterized in the early stages by a proliferation of poorly differentiated vessels followed in the late stages by a vascular differentiation and regression of the tumor, represent an interesting model to study angioge...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1999.tb01785.x

    authors: Verkarre V,Patey-Mariaud de Serre N,Vazeux R,Teillac-Hamel D,Chretien-Marquet B,Le Bihan C,Leborgne M,Fraitag S,Brousse N

    更新日期:1999-01-01 00:00:00

  • Early histopathology of the cutaneous capillary fragility test (Rumpel-Leede).

    abstract::The characteristic histologic change seen at 2 h in the Rumpel-Leede (Hess) test is, in addition to focal hemorrhage in the upper dermis, a perivascular lymphocyte infiltrate with focal areas of lymphocytic epidermal invasion. The histologic findings, even with the liquefaction degeneration, are similar to those of pu...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1979.tb00300.x

    authors: Duncan SC,Winkelmann RK

    更新日期:1979-02-01 00:00:00

  • Hypocellular medallion-like dermal dendrocyte hamartoma on the abdomen of a 25 year old male.

    abstract::Medallion-like dermal dendrocyte hamartoma is a rare congenital lesion that is more commonly seen in females. It often presents at birth on the neck or upper trunk as a well-circumscribed, atrophic patch with wrinkling of the overlying skin. Clinically, the differential diagnosis includes atrophoderma, anetoderma, and...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13421

    authors: Porubsky CF,Combs A,Buckley C,Goodman MB

    更新日期:2019-04-01 00:00:00

  • A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy.

    abstract::Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12435

    authors: Hibler J,Salavaggione AL,Martin A,Gru AA

    更新日期:2015-04-01 00:00:00

  • CDX2 and LEF-1 expression in pilomatrical tumors and their utility in the diagnosis of pilomatrical carcinoma.

    abstract:BACKGROUND:The Wnt signaling pathway has been implicated in the pathogenesis of pilomatrical tumors. Lymphoid enhancer-binding factor 1 (LEF-1) is a downstream component of this pathway, and Caudal-related homeobox transcription factor 2 (CDX2) has been postulated to regulate it, but little is known about expression of...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13113

    authors: Tumminello K,Hosler GA

    更新日期:2018-05-01 00:00:00

  • Analysis of the signal transduction pathway of nickel-induced matrix metalloproteinase-2 expression in the human keratinocytes in vitro: preliminary findings.

    abstract:BACKGROUND:Nickel can induce cellular and nuclear damages responsible for chronic diseases, like allergic contact dermatitis (ACD). We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). OBJECTIVE:To investigate the si...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2006.00647.x

    authors: Perfetto B,Lamberti M,Giuliano MT,Canozo N,Cammarota M,Baroni A

    更新日期:2007-06-01 00:00:00

  • Non-sentinel lymph node involvement in a patient with an atypical Spitz tumor and a positive sentinel node. Report of a case and review of the literature.

    abstract::We report a 20-year-old male patient with an atypical Spitz tumor, located in the dorsal aspect of his left hand, and a positive sentinel axillary lymph node. After lymphadenectomy, 1 of 23 non-sentinel lymph nodes excised was found to contain small multiple deposits of large spindle atypical melanocytes. Reviewing th...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0560.2008.01080.x

    authors: Urso C,Borgognoni L,Doria M,Tinacci G,Zini E

    更新日期:2009-05-01 00:00:00

  • Immunohistochemistry utilization in the diagnosis of melanoma.

    abstract:BACKGROUND:The use of immunohistochemical (IHC) stains in dermatopathology is commonplace; however, little is known regarding utilization trends in melanoma diagnosis. Current Medicare local coverage determinations (LCDs) state that most pigmented lesions, including melanoma, can be diagnosed using H&E alone. METHODS:...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13648

    authors: Dinehart MS,Dinehart SM,Sukpraprut-Braaten S,High WA

    更新日期:2020-05-01 00:00:00

  • Atypical fibrous histiocytoma of the skin and subcutis in childhood and adolescence.

    abstract::The authors have observed 15 examples of a distinctive fibrohistiocytic lesion in children and adolescents which they chose to designate as "atypical fibrous histiocytoma" (AFH). Patient ages ranged from 1 to 19 years (mean 9.3 yr.). Only two cases were encountered in the first year of life, but 7 were seen in childre...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1992.tb01362.x

    authors: Marrogi AJ,Dehner LP,Coffin CM,Wick MR

    更新日期:1992-08-01 00:00:00

  • Evaluation of DNA ploidy in dysplastic and Spitz nevi by flow cytometry.

    abstract::As many as 40% of all primary cutaneous melanomas can have histologic remnants of nevomelanocytic nevi adjacent to the tumor. There is increasing evidence that dysplastic nevi are at least a clinical marker for melanoma risk. Spitz nevi are not known for such an association, but are noteworthy because of their histolo...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1990.tb00110.x

    authors: Winokur TS,Palazzo JP,Johnson WC,Duray PH

    更新日期:1990-12-01 00:00:00

  • Eccrine proliferation with follicular mucinosis.

    abstract::Proliferation of the eccrine sweat duct epithelium has been associated with skin tumors, especially keratoacanthomas and basal cell carcinomas. We report our observations on the extensive sweat gland changes in a patient who had idiopathic follicular mucinosis. ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1987.tb00495.x

    authors: Berger TG,Goette DK

    更新日期:1987-06-01 00:00:00

  • Clear cell 'sugar' tumor (PEComa) of the skin: a case report.

    abstract::The so-called perivascular epithelioid cell neoplasm (PEComa) family includes angiomyolipoma, clear cell 'sugar' tumor (CCST), lymphangioleiomyomatosis, and clear cell myomelanocytic tumor (CCMMT). These rare tumors are characterized by the co-expression of melanocytic and muscle markers. They have been recognized in ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2005.00347.x

    authors: de Saint Aubain Somerhausen N,Gomez Galdon M,Bouffioux B,Courtin C,Theunis A,Vogeleer MN,Myant N

    更新日期:2005-07-01 00:00:00

  • Oral melanoacanthoma with prominent spongiotic intraepithelial vesicles.

    abstract::Oral melanoacanthoma is a rarely-reported, benign pigmented lesion of oral mucosa. Spongiosis was only recently mentioned as a light-microscopical finding occasionally seen in oral melanoacanthoma, and the formation of spongiotic intraepithelial vesicles to our knowledge has never been reported. The authors discuss a ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1989.tb00587.x

    authors: Zemtsov A,Bergfeld WF

    更新日期:1989-12-01 00:00:00

  • De novo intraepidermal epithelioid melanocytic dysplasia: a review of 263 cases.

    abstract:BACKGROUND:De novo intraepidermal epithelioid melanocytic dysplasia (DNIEMD) is a newly characterized lesion that is associated with a personal and/or family history of malignant melanoma (MM) and/or dysplastic nevi (DN). However, the biological significance is still uncertain and the persons predisposed to this lesion...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2009.01429.x

    authors: Jessup CJ,Cohen LM

    更新日期:2010-08-01 00:00:00

  • Ulcerated dermatofibroma with osteoclast-like giant cells.

    abstract:BACKGROUND:Ulceration and osteoclast-like giant cells are two pathological features uncommonly seen in dermatofibromas. To our knowledge, the presence of these features has not been previously described within the same lesion. METHODS:We report the clinical, histopathological and immunohistochemical findings of a 38-y...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2009.01195.x

    authors: González-Vilas D,García-Gavín J,Ginarte M,Rodríguez-Blanco I,Toribio J

    更新日期:2009-10-01 00:00:00

  • Myxoid variant of primary cutaneous anaplastic large cell lymphoma: First 2 cases.

    abstract::Anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell non-Hodgkin lymphoma with 2 main clinical presentations: primary cutaneous ALCL (pcALCL) and systemic ALCL (sALCL). While rare cases of myxoid sALCL have been reported, there are no previous cases of myxoid pcALCL reported. We present 2 unusual cases of pcALCL sh...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.12983

    authors: Fernandez-Flores A,Eginli A,Cassarino DS

    更新日期:2017-09-01 00:00:00

  • Follicular mycosis fungoides: a case report and review of the literature.

    abstract:BACKGROUND:Follicular mycosis fungoides is an unusual variant of mycosis fungoides (MF). Unlike classic MF where atypical lymphocytes show a predilection for the epidermis (epidermotropism), follicular MF displays a malignant lymphocytic infiltrate tropic for hair follicles (folliculotropism). This malignant lymphocyti...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0560.2001.028006318.x

    authors: DeBloom J 2nd,Severson J,Gaspari A,Scott G

    更新日期:2001-07-01 00:00:00

  • Dermatofibroma is a clonal proliferative disease.

    abstract::Benign fibrous histiocytoma of the skin or dermatofibroma (DF) has been regarded as a fibrohistiocytic tumor. Whether DF is a neoplastic growth or a reactive process has not been settled. Since a neoplastic process is clonal in nature, clonal analysis of DF was conducted to see if DF is a clonal disease. Fresh specime...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0560.2000.027001036.x

    authors: Chen TC,Kuo T,Chan HL

    更新日期:2000-01-01 00:00:00

  • A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12 approximately 12.3 in a Chinese family.

    abstract:BACKGROUND:Hereditary hypotrichosis simplex (MIM 146520, HHS) is a rare form of nonsyndromic alopecia. The locus for autosomal dominant HHS was mapped to 18p11.32-p11.23 and 6p21.3, respectively, suggestive of genetic heterogeneity. AIM:To identify the disease-causing gene for a four-generation Chinese family with dom...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2009.01415.x

    authors: Xu C,Zhang L,Chen N,Su B,Pan CM,Li JY,Zhang GW,Liu Z,Sheng Y,Song HD

    更新日期:2010-07-01 00:00:00

  • Sudoriferous acrosyringeal acantholytic disease. A subset of Grover's disease.

    abstract::Three selected cases of transient acantholytic dermatosis were studied because of their definitive correlation with sweating due to fever and/ or bed-ridden situations. Biopsy specimens were serially sectioned and acantholysis was found in the acrosyringium or traced to connect to the acrosyringium in all biopsy speci...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1996.tb01289.x

    authors: Hashimoto K,Moiin A,Chang MW,Tada J

    更新日期:1996-04-01 00:00:00

  • An unusual presentation of a congenital benign apocrine hamartoma.

    abstract::A case of an unusual benign apocrine hamartoma was studied by light microscopic, immunohistochemical, and electron microscopic methods. This tumor clinically showed a linear configuration and was located on the midline chest of a pubescent male. Microscopic studies revealed features of both a tubular apocrine adenoma ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1990.tb01678.x

    authors: Epstein BA,Argenyi ZB,Goldstein G,Whitaker D

    更新日期:1990-02-01 00:00:00

  • Ultrastructural characterization of the extramammary Paget cell plasma membrane: a freeze-fracture study.

    abstract::The plasma membrane ultrastructure of the extramammary Paget cells was characterized by freeze-fracture electron microscopy, which was first employed for the study of Paget cells. The Paget cell plasma membrane revealed a flat fractured plane with much fewer and smaller desmosome-particle aggregations than those of th...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1980.tb01210.x

    authors: Kitajima Y,Mori S

    更新日期:1980-12-01 00:00:00

  • T6+ and HLA-DR+ cell numbers in epidermis of immunosuppressed renal transplant recipients.

    abstract::The increased susceptibility of the skin of chronically immunosuppressed individuals to viral infections and sunlight-induced malignancies suggests specific drug-induced, dysfunction of local immune mechanisms within the sun-exposed skin of these individuals. To help understand the effect of immunosuppressive therapy ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1987.tb01333.x

    authors: Kelly G,Scheibner A,Murray E,Sheil R,Tiller D,Horvath J

    更新日期:1987-08-01 00:00:00

  • Epithelioid sarcoma arising on the nose of a child: a case report and review of the literature.

    abstract::A 4-year-old boy presented with a 6-month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor ce...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0560.2000.027004186.x

    authors: Billings SD,Hood AF

    更新日期:2000-04-01 00:00:00

  • Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal.

    abstract:BACKGROUND:Cutaneous tumor metastasis may be the first manifestation of cancer, but more often is a harbinger of advanced disease that portends an ominous prognosis. All skin accessions over the past 10 years from a large Veterans Administration (VA) hospital were reviewed. METHODS:Archived histories, glass slides, an...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2004.00207.x

    authors: Saeed S,Keehn CA,Morgan MB

    更新日期:2004-07-01 00:00:00

  • Annular hemosiderotic histiocytoma.

    abstract::A 35-year-old woman was examined because of a symptomless multiple annular eruption. The lesion consisted of rings of closely set, smooth, firm papules that were brown in color. Hemosiderotic histiocytoma was diagnosed by light and electron microscopy. Ultrastructurally, the lesion consisted of fibroblastic and histio...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1981.tb01006.x

    authors: Saga K

    更新日期:1981-06-01 00:00:00

  • Internal organization of plasma membranes during the acantholytic process. A freeze-fracture study.

    abstract::The internal organization of plasma membranes was studied in seven subjects with pemphigus vulgaris and in one subject with familial pemphigus using the freeze-fracture technique. The results obtained seem to suggest that the acantholytic process is produced in a similar fashion whatever the pathogenic agent and that ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1980.tb01184.x

    authors: Caputo R,Innocenti M,Gasparini G

    更新日期:1980-04-01 00:00:00

  • Congenital cutaneous lymphadenoma.

    abstract::Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only 1 previous case of a congenital lymphadenoma. ...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13016

    authors: Fernandez-Flores A,Nicklaus-Wollenteit I,Sathishkumar D,Diba V,Richard B,Carr R,Moss C,Nagy A,Ogboli M,Colmenero I

    更新日期:2017-11-01 00:00:00

  • A rare cutaneous adnexal neoplasm: cystic panfolliculoma.

    abstract::A cystic panfolliculoma is a benign follicular neoplasm which recapitulates several portions of the hair follicle. The patient was a 64-year-old Caucasian female who presented with a new growth on her right forearm. The lesion had slowly enlarged over the previous 11 months. She complained of it bleeding on several oc...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.12807

    authors: Neill B,Bingham C,Braudis K,Zurowski S

    更新日期:2016-12-01 00:00:00

  • The many masks of cutaneous Lyme disease.

    abstract::Early cutaneous Lyme disease, erythema migrans, may show different histopathologic patterns. The intent of this case series is to raise awareness of these findings to prevent misdiagnosis and keep this entity in the differential. Erythema migrans develops after a tick bite and subsequent infection with the spirochete,...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12620

    authors: Miraflor AP,Seidel GD,Perry AE,Castanedo-Tardan MP,Guill MA,Yan S

    更新日期:2016-01-01 00:00:00