Abstract：
BACKGROUND:Silver dressings have been widely and successfully used to prevent cutaneous wounds, including burns, chronic ulcers, dermatitis and other cutaneous conditions, from infection. However, in a few cases, skin discolouration or argyria-like appearances have been reported. This study investigated the level of silver in scar tissue post-burn injury following application of Acticoat, a silver dressing. METHODS:A porcine deep dermal partial thickness burn model was used. Burn wounds were treated with this silver dressing until completion of re-epithelialization, and silver levels were measured in a total of 160 scars and normal tissues. RESULTS:The mean level of silver in scar tissue covered with silver dressings was 136 microg/g, while the silver level in normal skin was less than 0.747 microg/g. A number of wounds had a slate-grey appearance, and dissection of the scars revealed brown-black pigment mostly in the middle and deep dermis within the scar. The level of silver and the severity of the slate-grey discolouration were correlated with the length of time of the silver dressing application. CONCLUSIONS:These results show that silver deposition in cutaneous scar tissue is a common phenomenon, and higher levels of silver deposits and severe skin discolouration are correlated with an increase in the duration of this silver dressing application.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Wang XQ,Chang HE,Francis R,Olszowy H,Liu PY,Kempf M,Cuttle L,Kravchuk O,Phillips GE,Kimble RMdoi
10.1111/j.1600-0560.2008.01141.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
788-92issue
7eissn
0303-6987issn
1600-0560pii
CUP1141journal_volume
36pub_type
杂志文章abstract：:Nm23 is a gene with a putative metastasis-suppressor function, whose expression is inversely correlated with the metastatic potential of some solid malignancies. Because very few data exist concerning the role of nm23 in skin tumors, we studied the immunohistochemical expression of nm23 gene product in frozen sections...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1997.tb01569.x
更新日期：1997-03-01 00:00:00
abstract：:Steatocystoma multiplex is characterized by the development of numerous steatocystomas. The condition has occasionally been related to congenital bilateral preauricular sinuses. Herein, we present the third case of such an association, a 34-year-old male who was born with bilateral preauricular sinuses that were surgi...
journal_title：Journal of cutaneous pathology
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abstract：:White sponge nevus (WSN) is an uncommon benign inherited disorder characterized by white and diffuse painless lesions in oral, esophageal, or genital mucosa. The lesions may develop at birth or later in childhood or adolescence, with careful clinical examination being sufficient for diagnosis in most cases. However, m...
journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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doi：10.1034/j.1600-0560.2001.280703.x
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abstract：:Alpha-1 anti-trypsin (A1AT) deficiency is an inherited enzyme deficiency that manifests with fatal lung and liver complications. In addition to pulmonary and hepatic involvement, the disease has also been linked to an increased incidence of vasculitic syndromes and autoimmune diseases, including Wegener's granulomatos...
journal_title：Journal of cutaneous pathology
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doi：10.1111/j.0303-6987.2005.00304.x
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abstract：:We report a case of a 68-year-old man with cutaneous leiomyosarcoma of the penis. Leiomyosarcoma of the penis is an extremely rare neoplasm that usually presents in middle to old age, and to our knowledge only approximately 30 cases have been reported in the literature to date. This is an important diagnosis in the di...
journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.2007.00846.x
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journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.1990.tb00099.x
更新日期：1990-10-01 00:00:00
abstract：:The three-dimensional morphology of six dermatofibromas was studied by scanning electron microscopy. Hypertrophic epidermal ridges covered with large keratinized cells overlay each dermal lesion. Small collagenous fibers in the tumors contrasted with the bundles of much larger collagenous fibers in the normal dermis p...
journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.1979.tb01141.x
更新日期：1979-08-01 00:00:00
abstract：:LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral inje...
journal_title：Journal of cutaneous pathology
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doi：10.1111/cup.13262
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journal_title：Journal of cutaneous pathology
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doi：10.1111/cup.12007
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abstract：:A case of reactive perforating collagenosis in an adult male patient with chronic renal failure. Pruritic, umbilicate papules, showing extrusion of collagen fibers through the epidermis were detected histopathologically. Electron microscopy showed absence of basal membrane beneath the perforation and collagen fibers w...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1988.tb00532.x
更新日期：1988-04-01 00:00:00
abstract：:Although non-specific skin lesions are quite common in patients with leukemia, the specific infiltration of the skin by blast cells, known as leukemia cutis, is rare. Its incidence ranges from 1 to 50% and depends on the specific type of leukemia. Leukemic vasculitis represents a rare form of leukemia cutis consisting...
journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.2010.01623.x
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1993.tb00644.x
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) occasionally resemble each other histologically but differ in histogenesis and biological behavior. This study sought to determine if these lesions can be differentiated by the quantity or quality of expression of cyclooxygenase-2 (COX-2), an enz...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2007.00855.x
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abstract：:Erythrodermic cutaneous T-cell lymphoma (E-CTCL) is the cause of less than 5% of all cases of generalized erythroderma. A methodical evaluation of skin, blood, and lymph node samples using standard histology, immunohistochemistry (IHC), flow cytometry (FC), and molecular analysis for evidence of a dominant T-cell clon...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.0303-6987.2006.00541.x
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abstract：BACKGROUND:Among the pigmented lesions with a central area of scar, we found a group of cases histologically characterized by striking architectural alteration of the melanocytic component, but with no cytological atypia and mitotically quiescent. The aim of the current study was to assess the biological nature of such...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2007.00941.x
更新日期：2008-11-01 00:00:00
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journal_title：Journal of cutaneous pathology
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doi：10.1111/j.0303-6987.2005.00242.x
更新日期：2005-01-01 00:00:00
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.2006.00612.x
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journal_title：Journal of cutaneous pathology
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更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:The histopathologic findings of localized reactions to tick bites may present as diagnostic dilemmas, especially if there is no history of a tick bite, or if the tick's mouthparts are not present in the biopsied skin. OBJECTIVE:Skin biopsies of patients with a clinical history of a tick bite were selected a...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2001.290207.x
更新日期：2002-02-01 00:00:00
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.1997.tb01457.x
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.13263
更新日期：2018-07-01 00:00:00
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.2008.01080.x
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1996.tb01316.x
更新日期：1996-08-01 00:00:00
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1995.tb01400.x
更新日期：1995-04-01 00:00:00
abstract：:CD44 is a widely distributed cell surface protein thought to be involved in multiple steps of normal immune cell function, including T-cell activation, and in cellular adhesion where it mediates cell attachment to hyaluronate. In normal skin, CD44 is found by immunohistochemical means to be primarily in eccrine coil c...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1994.tb00265.x
更新日期：1994-06-01 00:00:00
