Abstract:
:CD44 is a widely distributed cell surface protein thought to be involved in multiple steps of normal immune cell function, including T-cell activation, and in cellular adhesion where it mediates cell attachment to hyaluronate. In normal skin, CD44 is found by immunohistochemical means to be primarily in eccrine coil cells. In this study, we have looked at the expression of CD44 in normal scalp and in two different hair disorders, androgenetic alopecia and alopecia areata. In normal scalp and androgenetic alopecia, CD44 was found in its normal distribution in eccrine coil cells. In scalp of 30 patients with alopecia areata, there was no expression of this glycoprotein. Patients were also assessed pre and post treatment for their alopecia areata, and even though they had no significant hair regrowth, 2 patients regained expression of CD44, indicating a variable expression of this protein in the alopecia areata disease process. The absence of CD44 expression in alopecia areata-affected scalp may give further information regarding the pathogenesis of this disease.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Sawaya ME,Bakshandeh H,Hordinsky MK,Penneys NSdoi
10.1111/j.1600-0560.1994.tb00265.xsubject
Has Abstractpub_date
1994-06-01 00:00:00pages
229-32issue
3eissn
0303-6987issn
1600-0560journal_volume
21pub_type
杂志文章abstract::Traditionally, melanoma has been considered by surgeons to be a highly lethal malignancy, always requiring a radical surgical approach for optimal chance of cure. Yet melanoma patients who are now being referred for treatment frequently have small early lesions, and surgeons should develop a flexible attitude about ma...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1979.tb01127.x
更新日期:1979-06-01 00:00:00
abstract::Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nail clinic complaining of discoloration of the lunula of the left...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12645
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Considerable controversy has surrounded the question of possible biological responses to electromagnetic fields (EMFs) generated from visual display terminals (VDTs), such as personal computers (PCs) and ordinary television sets (TVs). The cellular and molecular mechanisms for such potential harmful health h...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1034/j.1600-0560.2001.281004.x
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Studies on the precise cause of increased melanization in pigmented basal cell carcinomas (BCC) are limited. We aimed to determine whether the cause of melanization is from increased number of melanocytes or increased melanin pigment, and if there is a difference in the number of melanocytes on different sun...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12819
更新日期:2016-12-01 00:00:00
abstract::Cutaneous syncytial myoepithelioma is a recently described rare tumor of the dermis. It is derived and composed purely of myoepithelial cells and shows a characteristic syncytial growth pattern of neoplastic cells with little intervening stroma and no recognizable ductal structures. It represents a diagnostic challeng...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.13005
更新日期:2017-10-01 00:00:00
abstract::Epidermolytic hyperkeratosis (EH) is a well-described histopathologic pattern characteristic of bullous congenital ichthyosiform erythroderma, an autosomal dominant genodermatosis. It is also noted in cutaneous disorders where mosaicism leads to containment of the clinical and histopathologic changes. EH has been obse...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2006.00612.x
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas. METHODS:To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions. RESULTS:Me...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.0303-6987.2005.00282.x
更新日期:2005-02-01 00:00:00
abstract::Trichilemmoma is considered a benign neoplasm derived from the outer root sheath of the hair follicle. Although the histogenesis of the lesion is unknown, a relationship between human papillomavirus (HPV) infection and development of these tumors has been suggested on morphologic observations. In order to determine wh...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1991.tb00152.x
更新日期:1991-06-01 00:00:00
abstract::A case of an unusual benign apocrine hamartoma was studied by light microscopic, immunohistochemical, and electron microscopic methods. This tumor clinically showed a linear configuration and was located on the midline chest of a pubescent male. Microscopic studies revealed features of both a tubular apocrine adenoma ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1990.tb01678.x
更新日期:1990-02-01 00:00:00
abstract::A tumor of 60 years' duration overlying the sternum of an 87-year-old woman is described. Histologically, the tumor was composed of lobules and cords of epithelial cells with finely granular, eosinophilic cytoplasm. The epithelial nests were floating in large pools of mucinous stroma, separated by thin fibrovascular s...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1991.tb00140.x
更新日期:1991-04-01 00:00:00
abstract::An 11-month-old female with focal dermal hypoplasia syndrome is described. Histologically, the skin lesions were characterized by a marked decrease in dermal connective tissue. Ultrastructurally, there were a number of fine filamentous structures measuring 5 to 70 nm within and between the bundles of collagen; most of...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1982.tb01063.x
更新日期:1982-08-01 00:00:00
abstract::Early cutaneous Lyme disease, erythema migrans, may show different histopathologic patterns. The intent of this case series is to raise awareness of these findings to prevent misdiagnosis and keep this entity in the differential. Erythema migrans develops after a tick bite and subsequent infection with the spirochete,...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12620
更新日期:2016-01-01 00:00:00
abstract::Two elderly patients with unusual hair-follicle tumors of the face are reported. The lesions showed some histologic resemblance to pilomatrixomas but differed by the presence at the advancing edge of cytologically-atypical cells without the usual shadow cell transformation and maturation of pilomatrixomas. The term ma...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1980.tb00975.x
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:The GATA family of transcription factors is an essential regulator of cellular proliferation and differentiation. In the skin, GATA-3 is critical for epidermal stratification and maintenance of barrier function. A role for GATA-3 in the development of human cutaneous squamous cell carcinoma (SCC) is not know...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12667
更新日期:2016-04-01 00:00:00
abstract::Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic ...
journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.13398
更新日期:2019-03-01 00:00:00
abstract::The increased susceptibility of the skin of chronically immunosuppressed individuals to viral infections and sunlight-induced malignancies suggests specific drug-induced, dysfunction of local immune mechanisms within the sun-exposed skin of these individuals. To help understand the effect of immunosuppressive therapy ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1987.tb01333.x
更新日期:1987-08-01 00:00:00
abstract::Lesions of seborrheic keratoses were studied by scanning electrom microscopy. Numerous yeasts were present on the karatinized cells and hairs associated with the lesions. Surfaces of some yeasts were smooth and others were ruffled. The ruffles suggested the presence of a glycocalyx. The yeasts exhibited the morphologi...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1980.tb00971.x
更新日期:1980-02-01 00:00:00
abstract::Nm23 is a gene with a putative metastasis-suppressor function, whose expression is inversely correlated with the metastatic potential of some solid malignancies. Because very few data exist concerning the role of nm23 in skin tumors, we studied the immunohistochemical expression of nm23 gene product in frozen sections...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1997.tb01569.x
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2011.01706.x
更新日期:2011-08-01 00:00:00
abstract::We report a new case of a Japanese man who developed a tubular apocrine adenoma in association with syringocystadenoma papilliferum. The differences in the histopathological and immunohistochemical findings in these 2 tumors are described. This is the first immunohistochemical study of tubular apocrine adenoma. ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1989.tb00047.x
更新日期:1989-08-01 00:00:00
abstract::Verrucous hemangioma represents a rare congenital vascular proliferation that may be mistaken for angiokeratoma. Histopathological examination of a deep biopsy is necessary to confirm the diagnosis of verrucous hemangioma based on its involvement of the deep dermis and subcutaneous tissue. We present two cases of verr...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0560.2011.01733.x
更新日期:2011-09-01 00:00:00
abstract::Neurofibromatosis type 1 is a relatively common genetic disorder with variable phenotypes. Tumors with features of both glomus tumors and neurofibromas are exceedingly rare in literature. Herein, we report a not yet described neoplasm with features of both a glomangioma/glomus tumor and a neurofibroma arising in a pat...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12439
更新日期:2015-04-01 00:00:00
abstract::The development of cancer involves epithelial-stromal interactions. Alterations in the synthesis and deposition of type I and III collagens are related to the tumor morphology. Skin carcinogenesis in experimental animals provides a reliable model for the development of neoplasia. Ultraviolet (UV) irradiation is the ma...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1999.tb01854.x
更新日期:1999-08-01 00:00:00
abstract::Light and electron-microscopic studies were performed on the amelanotic and adjacent normal-appearing skin in patients with vitiligo. The amelanotic skin revealed complete loss of pigment and absence of melanocytes. In addition to severe degenerative changes of melanocytes, varying degree of damage was also seen in th...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1983.tb00328.x
更新日期:1983-06-01 00:00:00
abstract::We first report a case of granular cell histiocytosis occurring as a solitary polypoid lesion of the nipple in a 15-year-old girl. Histologically, the lesion was composed of a dermal population of medium- to large-sized, short spindle- to round- to epithelioid-shaped cells with eosinophilic cytoplasm containing numero...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2009.01305.x
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Long-term preservation of immunofluorescence is important for re-examinations. We investigated whether the storage of direct immunofluorescent (DIF)-positive slides at room temperature was reliable in daily practice. METHODS:One hundred and twenty-five DIF-positive slides from the skin of 52 patients were e...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1034/j.1600-0560.2003.00071.x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Tumor-infiltrating lymphocytes (TILs) are considered to play an important role in the antitumoral immune response. The presence and percentage of CD8-positive tumor-infiltrating T cells have been shown to correlate with differentiation and prognosis in various neoplasms. The aim of this study was to determin...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1034/j.1600-0560.2001.028009448.x
更新日期:2001-10-01 00:00:00
abstract::Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatmen...
journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.13140
更新日期:2018-06-01 00:00:00
abstract::Steatocystoma multiplex is characterized by the development of numerous steatocystomas. The condition has occasionally been related to congenital bilateral preauricular sinuses. Herein, we present the third case of such an association, a 34-year-old male who was born with bilateral preauricular sinuses that were surgi...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12315
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Chromoblastomycosis is a chronic, suppurative, granulomatous mycosis usually confined to skin and subcutaneous tissues. The host defense mechanisms in chromoblastomycosis have not been extensively investigated. The purpose of the present study was to determine the distribution and pathways of the fungal anti...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1046/j.0303-6987.2004.0131.x
更新日期:2004-01-01 00:00:00