Paraneoplastic pemphigus: a subset of patients with pemphigus and neoplasia.

Abstract:

:We reviewed the clinical, histologic, and immunofluorescence features of 20 patients with pemphigus and neoplasia and compared them with a control group of 17 patients with pemphigus without neoplasia. Patients with neoplasia were divided according to clinical, histologic, and immunofluorescence findings into those with paraneoplastic pemphigus syndrome (12 patients) and those with classic pemphigus vulgaris or pemphigus foliaceus with neoplasia (8 patients). The histologic findings in patients with paraneoplastic pemphigus included acantholysis, interface dermatitis, spongiosis, and satellite keratinocyte necrosis. Histologic findings in the 8 patients with classic pemphigus and neoplasia included acantholysis and spongiosis. Direct immunofluorescence in both paraneoplastic pemphigus and pemphigus with neoplasia showed IgG staining of cell-surface proteins (intercellular substance) and deposition of immunoglobulin at the basement membrane zone. Indirect immunofluorescence with rat bladder substrate was used to differentiate paraneoplastic pemphigus from classic pemphigus. Circulating IgG anti-cell-surface protein antibodies were detected in 4 patients with paraneoplastic pemphigus syndrome; they were absent in 2 patients with pemphigus and neoplasia. Immunoprecipitation of sera from the 4 patients with epithelial staining showed the complex of bands identified in studies of paraneoplastic pemphigus syndrome. We conclude that paraneoplastic pemphigus syndrome has distinct clinical, histologic, and immunologic features that differentiate it from classic pemphigus with underlying neoplasia.

journal_name

J Cutan Pathol

authors

Mehregan DR,Oursler JR,Leiferman KM,Muller SA,Anhalt GJ,Peters MS

doi

10.1111/j.1600-0560.1993.tb00644.x

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

203-10

issue

3

eissn

0303-6987

issn

1600-0560

journal_volume

20

pub_type

杂志文章
  • Langerhans cell histiocytosis and Erdheim-Chester disease, both with cutaneous presentations, and papillary thyroid carcinoma all harboring the BRAF(V600E) mutation.

    abstract::Langerhans cell histocytosis (LCH) and Erdheim-Chester disease are two rare histiocytic disorders. Their occurrence in the same patient is more infrequent, but has been described. We report a case of a 38-year-old woman who presented with a diagnosis of single system cutaneous LCH. Subsequently, she developed multiple...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12636

    authors: Johnson WT,Patel P,Hernandez A,Grandinetti LM,Huen AC,Marks S,Ho J,Monaco SE,Jaffe R,Picarsic J

    更新日期:2016-03-01 00:00:00

  • Polarizable crystals in apocrine sweat gland tumors: A series of 3 cases.

    abstract::Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphological...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.12962

    authors: Johnson G,Gardner JM,Shalin SC

    更新日期:2017-08-01 00:00:00

  • Necrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma.

    abstract::The histopathologic findings in 331 cases of necrobiosis lipoidica diabeticorum seen during a 50-year period were reviewed. Three cases showing cholesterol cleft formation were found. All 3 cases were associated with severe diabetes mellitus. The differential diagnosis of importance is necrobiotic xanthogranuloma. Com...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1988.tb00509.x

    authors: Gibson LE,Reizner GT,Winkelmann RK

    更新日期:1988-02-01 00:00:00

  • Poorly differentiated squamous cell carcinomas of the skin can express vimentin.

    abstract::Thirty cases of poorly differentiated carcinomas of the skin were examined for the expression of vimentin. All cases expressed cytokeratins; in addition, 12 cases were positive for vimentin. These were all non-reactive with antibodies to S100 protein, HMB45 and desmin. The finding of vimentin in poorly differentiated ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1992.tb01556.x

    authors: Iyer PV,Leong AS

    更新日期:1992-02-01 00:00:00

  • Metastatic follicular carcinoma of the thyroid to the skin: a case confirmed by immunohistochemistry.

    abstract::A 78-year-old woman with a history of follicular carcinoma of the thyroid developed a painless nodule on her face. A skin biopsy showed a dermal tumor composed of cells with granular, eosinophilic cytoplasm. Immunoperoxidase staining demonstrated thyroglobulin in the tumor cells, confirming the diagnosis of metastatic...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1985.tb01609.x

    authors: Rico MJ,Penneys NS

    更新日期:1985-04-01 00:00:00

  • Histology of benign virus induced tumors of the skin.

    abstract::The majority of findings in relation to warts have been passed on from one textbook to the other since the end of the last century. More recent studies have been carried out with the electron microscope. But information is lacking as to histology, histochemistry, examination with the phase-contrast microscope, with th...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1978.tb00938.x

    authors: Steigleder GK

    更新日期:1978-04-01 00:00:00

  • Adhesion molecule expression in normal skin and melanocytic lesions. Role of UV-irradiation and architectural characteristics in nevi.

    abstract::Cell adhesion between surfaces of cells and to extracellular matrices represents a fundamental mechanism in tissue organization and influences the biological behaviour and the architecture of tumors. We investigated the expression of various adhesion molecules in normal skin (n=5), nevi (n=29), and malignant melanoma ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1997.tb00792.x

    authors: Tronnier M,Alexander M,Wolff HH

    更新日期:1997-05-01 00:00:00

  • hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue.

    abstract:BACKGROUND:Telomerase plays a role in the immortalization of cells and carcinogenesis. Previous studies have yielded conflicting results on whether human telomerase RNA (hTER) expression differs in nevi, atypical nevi and melanomas using polymerase chain reaction-based telomeric repeat amplification protocol or in situ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2005.00403.x

    authors: Fullen DR,Zhu W,Thomas D,Su LD

    更新日期:2005-11-01 00:00:00

  • Vascular endothelial cell distribution and adhesion molecule expression in xanthoma.

    abstract:BACKGROUND:The migration of circulating monocytes into the dermis is considered to be essential for both the initiation and the progression of xanthoma. The contribution of vascular endothelial cells to the migration process is unclear. METHODS:Twenty cases of xanthelasma and six cases of tuberous xanthoma lesions wer...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2006.00701.x

    authors: Matsumoto M,Kunimitsu S,Wada K,Ikeda M,Yokogawa M,Keyama A,Kodama H

    更新日期:2007-10-01 00:00:00

  • Primary cutaneous lymphomas in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A series of 12 cases.

    abstract:BACKGROUND:Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is associated with an increased risk of a second malignancy. METHODS:We conducted a retrospective clinicopathologic review of 12 patients with CLL/SLL who developed a second lymphoma in the skin. Demographic data, clinical information, and hi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13956

    authors: Liu YA,Finn AJ,Subtil A

    更新日期:2021-01-07 00:00:00

  • Sarcomatoid pilomatrix carcinoma.

    abstract::Pilomatrix (pilomatrical) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only 4 cases previously published. We prese...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13151

    authors: Fernandez-Flores A,Cassarino DS

    更新日期:2018-07-01 00:00:00

  • Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides.

    abstract:INTRODUCTION:Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDCs) are a subset of interferon-producing dendritic cells that link the innate and the adaptative immune...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13438

    authors: Fernandez-Flores A,Cassarino DS

    更新日期:2019-05-01 00:00:00

  • A rare case of a periorbital respiratory (choristomatous) cyst.

    abstract::Respiratory cysts are benign lesions lined by normal respiratory epithelium. There are few reported cases localized to the orbit, while those of the eyelid are exceedingly rare. Respiratory cysts usually arise either from a non-hereditary congenital malformation, where they are distinguished as choristomatous, or from...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13898

    authors: Yeh C,Atillasoy C,Seykora JT,Lee V

    更新日期:2021-01-01 00:00:00

  • Ultrastructural localization of gap junction protein connexin 43 in normal human skin, basal cell carcinoma, and squamous cell carcinoma.

    abstract::The expression and localization of connexin 43 (Cx43) were investigated in normal human epidermis, pilosebaceous apparatus, basal cell carcinoma, and squamous cell carcinoma by immunofluorescence as well as by immunoelectron microscopy. In the normal epidermis the immunofluorescence was weak in the basal layer, increa...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1997.tb01094.x

    authors: Tada J,Hashimoto K

    更新日期:1997-11-01 00:00:00

  • Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm.

    abstract::Adenomyoepithelioma is a rare, microscopically distinctive tumor of the skin. This article explores an example that presented in the inguinal area in a 29-year-old woman, mimicking adenopathy. Histopathologically, the tumor included two different areas: a cystic area consisting of tubules and glands in hyalinized stro...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2012.01916.x

    authors: Sabater Marco V

    更新日期:2012-07-01 00:00:00

  • Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia (B-CLL) at sites typical for Borrelia burgdorferi infection.

    abstract:BACKGROUND:Cutaneous manifestations of B-cell chronic lymphocytic leukemia (B-CLL) comprise a wide spectrum of clinicopathologic presentations. In some cases, onset of skin lesions is triggered by antigenic stimulation, and specific skin infiltrates at sites of previous herpes simplex or herpes zoster infection have be...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0560.2002.290303.x

    authors: Cerroni L,Höfler G,Bäck B,Wolf P,Maier G,Kerl H

    更新日期:2002-03-01 00:00:00

  • Marjolin's ulcer: immunohistochemical study of 17 cases and comparison with common squamous cell carcinoma and basal cell carcinoma.

    abstract::Formalin-fixed, paraffin-embedded biopsy specimens of 17 cases of squamous cell carcinoma of Marjolin's ulcer (SCC-MU), 6 cases of common SCC (SCC), and 5 cases of basal cell carcinoma (BCC) were stained with three monoclonal antikeratin antibodies (CAM 5.2, MAK-6, and MA-903), a monoclonal antivimentin antibody (V9),...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1992.tb01363.x

    authors: Kim JM,Su WP,Kurtin PJ,Ziesmer S

    更新日期:1992-08-01 00:00:00

  • Ofuji's disease with follicular mucinosis and its differential diagnosis from alopecia mucinosa.

    abstract:OBJECTIVES:Ofuji's disease (OD) or eosinophilic pustular folliculitis and human immunodeficiency virus-associated eosinophilic folliculitis (HIV-EF) both show eosinophil-rich folliculocentric infiltrates, and it is not clear whether they are distinguishable pathologically. Follicular mucinosis (FM) has been observed in...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0560.2003.00076.x

    authors: Lee JY,Tsai YM,Sheu HM

    更新日期:2003-05-01 00:00:00

  • Incidental finding of a true human tail in an adult: a case report.

    abstract::True human tails are rare vestigial structures that are typically removed in childhood. Here a case is presented in which an inconspicuous sacrococcygeal tail was incidentally discovered in late adulthood. A 56-year-old man with no significant past medical history presented to a dermatology clinic with a chief complai...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.12820

    authors: Robinson CG,Duke TC,Allison AW

    更新日期:2017-01-01 00:00:00

  • When to suspect tinea; a histopathologic study of 103 cases of PAS-positive tinea.

    abstract:BACKGROUND:The histopathologic features of tinea vary widely and its diagnosis could be easily missed if the index of suspicion is not high. We aimed in this study to detect histopathologic features that could be a clue for diagnosis METHODS:We retrospectively reviewed 103 cases of tinea, confirmed by Periodic acid-Sc...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12757

    authors: Elbendary A,Valdebran M,Gad A,Elston DM

    更新日期:2016-10-01 00:00:00

  • CDX2 and LEF-1 expression in pilomatrical tumors and their utility in the diagnosis of pilomatrical carcinoma.

    abstract:BACKGROUND:The Wnt signaling pathway has been implicated in the pathogenesis of pilomatrical tumors. Lymphoid enhancer-binding factor 1 (LEF-1) is a downstream component of this pathway, and Caudal-related homeobox transcription factor 2 (CDX2) has been postulated to regulate it, but little is known about expression of...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13113

    authors: Tumminello K,Hosler GA

    更新日期:2018-05-01 00:00:00

  • Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?

    abstract::Pleomorphic fibromas represent dome-shaped or polypoid cutaneous lesions characterized by a paucicellular and densely fibrotic background punctuated by scattered atypical to pleomorphic spindle and multinucleated giant cells. Some of these tumors will have incorporated adipose tissue, although these adipocytic areas l...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12095

    authors: Al-Zaid T,Wang WL,Lopez-Terrada D,Lev D,Hornick JL,Hafeez Diwan A,Fletcher CD,Lazar AJ

    更新日期:2013-04-01 00:00:00

  • Secondary syphilis: a histologic and immunohistochemical evaluation.

    abstract::The usual method for detecting spirochetes in tissue sections is the silver stain; however, they are often difficult to detect due to marked background staining commonly seen with this technique. In certain clinical settings, such as neurosyphilis, congenital syphilis, and immunosuppressive conditions including human ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2004.00236.x

    authors: Hoang MP,High WA,Molberg KH

    更新日期:2004-10-01 00:00:00

  • Acquired perforating calcific collagenosis in a drug addict with rhabdomyolysis and transient hypercalcemia.

    abstract::Acquired perforating calcific collagenosis (APCC), which is characterized by the calcification of dermal collagen fibers with subsequent transepidermal elimination and perforation, is an extremely rare entity. Thus far, it has only been reported in a patient with direct contact exposure to calcium chloride. Here, we r...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13371

    authors: Wang FY,Ng CY,Wu J,Kuo KL,Chang YY,Kuo TT

    更新日期:2019-01-01 00:00:00

  • Oral mucosal melanoma with unusual clinicopathologic features.

    abstract::Oral mucosal melanoma (OMM) is an extremely rare malignancy, accounting for < 0.5% of all melanomas and all oral malignancies. The rarity of OMM, the heterogeneity in clinical and histopathologic appearances, and the paucity of molecular and genetic studies to date have limited our knowledge of the etiopathogenesis of...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2007.00830.x

    authors: Kumar SK,Shuler CF,Sedghizadeh PP,Kalmar JR

    更新日期:2008-04-01 00:00:00

  • Myrmecia wart inclusions as an incidental histopathologic finding.

    abstract:BACKGROUND:Latent infection by human papillomavirus (HPV) has been described for genital (mucosal) and epidermodysplasia verruciformis subtypes. Only rarely has cutaneotropic, non-oncogenic HPV been found by polymerase chain reaction studies in normal skin. METHODS:We noted myrmecia wart inclusions as an incidental hi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2012.01968.x

    authors: Wititsuwannakul J,Ko CJ

    更新日期:2012-10-01 00:00:00

  • Dermal abscesses with Staphylococcus aureus, cytomegalovirus and acid-fast bacilli in a patient with acquired immunodeficiency syndrome (AIDS).

    abstract::A 34-year-old man with acquired immunodeficiency syndrome presented with multiple skin lesions clinically suggestive of molluscum contagiosum. Three skin biopsy specimens were obtained which showed dermal abscesses containing multiple gram-positive cocci admixed with granular necrotic dermal material. In 2, there were...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1988.tb00517.x

    authors: Boudreau S,Hines HC,Hood AF

    更新日期:1988-02-01 00:00:00

  • Macrophage-rich epithelioid angiosarcoma mimicking malignant melanoma.

    abstract:BACKGROUND:Cutaneous epithelioid angiosarcoma is a type of cutaneous angiosarcoma and usually arise both on the head or neck of the elderly. CASE REPORT:An 86-year-old male with an epithelioid angiosarcoma of the scalp that mimicked malignant melanoma. RESULTS:A large irregular dark grey-blue plaque with an adjacent ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2006.00387.x

    authors: Brightman LA,Demierre MF,Byers HR

    更新日期:2006-01-01 00:00:00

  • C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin.

    abstract:BACKGROUND:Direct immunofluorescence (DIF) testing is an important procedure in the diagnosis of autoimmune bullous dermatoses. We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses. METHODS:The immunohistochemical expression of C3d in bullous pemphigoid (BP...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2009.01450.x

    authors: Pfaltz K,Mertz K,Rose C,Scheidegger P,Pfaltz M,Kempf W

    更新日期:2010-06-01 00:00:00

  • Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma.

    abstract::Cutaneous syncytial myoepithelioma is a recently described rare tumor of the dermis. It is derived and composed purely of myoepithelial cells and shows a characteristic syncytial growth pattern of neoplastic cells with little intervening stroma and no recognizable ductal structures. It represents a diagnostic challeng...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13005

    authors: Alomari AK,Brown N,Andea AA,Betz BL,Patel RM

    更新日期:2017-10-01 00:00:00