hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue.

abstract：:The bcl-2 proto-oncogene encodes a protein that protects cells from programmed cell death (apoptosis). High levels of this protein confer a growth advantage to neoplastic cells even in the absence of a high mitotic rate. This gene is involved in the interchromosomal 14;18 translocation, an abnormality present in more ...

journal_title：Journal of cutaneous pathology

authors： Cerroni L,Kerl H

更新日期：1994-10-01 00:00:00

abstract：:Primary cutaneous extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) represents a monoclonal B-cell neoplasm that typically presents with papules, plaques or nodules. We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenot...

journal_title：Journal of cutaneous pathology

authors： Edinger JT,Lorenzo CR,Breneman DL,Swerdlow SH

更新日期：2011-09-01 00:00:00

abstract：:Dirofilaria repens (formerly Dirofilaria conjunctiva) is a natural parasite of the subcutaneous tissues of dogs, cats and wild carnivores in Europe, Africa and Asia. Microfilariae are transmitted to humans by various species of mosquito. An autochthonous case of subcutaneous dirofilariasis is reported in a Greek patie...

journal_title：Journal of cutaneous pathology

authors： Tzanetou K,Gasteratos S,Pantazopoulou A,Gogou C,Konidaris D,Fragia K

更新日期：2009-08-01 00:00:00

abstract：:The rare presentation of choriocarcinoma as a cutaneous metastasis in a 23-year-old male is reported. Histological and immunohistochemical analysis of the biopsy material demonstrated two distinct cell populations, syncytiotrophoblasts and cytotrophoblasts, with syncytiotrophoblasts strongly positive for human chorion...

journal_title：Journal of cutaneous pathology

authors： Chhieng DC,Jennings TA,Slominski A,Mihm MC Jr

更新日期：1995-08-01 00:00:00

abstract：:Early cutaneous Lyme disease, erythema migrans, may show different histopathologic patterns. The intent of this case series is to raise awareness of these findings to prevent misdiagnosis and keep this entity in the differential. Erythema migrans develops after a tick bite and subsequent infection with the spirochete,...

journal_title：Journal of cutaneous pathology

authors： Miraflor AP,Seidel GD,Perry AE,Castanedo-Tardan MP,Guill MA,Yan S

更新日期：2016-01-01 00:00:00

abstract：:Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic me...

journal_title：Journal of cutaneous pathology

authors： Ward RE,Ali SA,Kuhar M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Although a range of cytomegalovirus (CMV)-induced cutaneous manifestations is described in AIDS patients, skin involvement in immunocompromised patients is rare, and intraneural CMV inclusions or CMV neuritis has not been documented in skin biopsies. METHODS AND RESULTS:Cutaneous biopsies of CMV lesions wer...

journal_title：Journal of cutaneous pathology

authors： Ramdial PK,Dlova NC,Sydney C

更新日期：2002-08-01 00:00:00

abstract：:Electron microscopy of lentigines was performed to study the pigmentation abnormality in two children with LEOPARD syndrome. Giant melanosomes similar to those seen in café-au-lait spots of neurofibromatosis and nevus spilus were found in a lentigine from one of our cases. Our results show that "spherical granular mel...

journal_title：Journal of cutaneous pathology

authors： Bhawan J,Purtilo DT,Riordan JA,Saxena VK,Edelstein L

更新日期：1976-01-01 00:00:00

abstract：:We have previously shown that human metallopanstimulin (MPS-1) is a ubiquitous 9.4-kDa multifunctional ribosomal S27/nuclear "zinc finger" protein which is expressed at high levels in a wide variety of cultured proliferating cells and tumor tissues, including melanoma. In the present study, we have examined the expres...

journal_title：Journal of cutaneous pathology

authors： Santa Cruz DJ,Hamilton PD,Klos DJ,Fernandez-Pol JA

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis displays considerable variation in its histopathological and clinical presentation. Clinically, it progresses from a papule into a painless ulcerated and crusted nodule/papule. Microscopically, it progresses from sheets of amastigote-filled histiocytes to granulomatous inflammation. ...

journal_title：Journal of cutaneous pathology

authors： Saab J,Fedda F,Khattab R,Yahya L,Loya A,Satti M,Kibbi AG,Houreih MA,Raslan W,El-Sabban M,Khalifeh I

更新日期：2012-02-01 00:00:00

abstract：:Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nail clinic complaining of discoloration of the lunula of the left...

journal_title：Journal of cutaneous pathology

authors： Komforti M,Selim MA,Bellet JS

更新日期：2016-04-01 00:00:00

abstract：:Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woma...

journal_title：Journal of cutaneous pathology

authors： Cohen PR,Prieto VG

更新日期：2010-08-01 00:00:00

abstract：:In the past decades, the incidence of melanoma has been reported to rise in epidemic proportions. The chief reason for that pseudo-epidemic is improved criteria for diagnosis that allow melanomas to be recognized far more accurately and at earlier stages. The rising number of melanomas diagnosed has resulted in increa...

journal_title：Journal of cutaneous pathology

authors： Weyers W

更新日期：2012-01-01 00:00:00

abstract：:The expression of cytokeratins in 10 cases of clear cell hidradenoma, including 3 cases of solid cystic hidradenoma, were examined using 21 kinds of monoclonal antibodies. We divided them into three histologic patterns: massive nests with a few lumina (M nests), nests with some tubular lumina (L nests), and nests in s...

journal_title：Journal of cutaneous pathology

authors： Ohnishi T,Watanabe S

更新日期：1997-01-01 00:00:00

abstract：:Thirty-six Swedish patients with the recessively inherited Sjögren-Larsson syndrome (SLS) were examined by histopathologic and, in some cases, morphometric techniques. Skin biopsy specimens were taken on the volar side of the right forearm below the cubital fossa. The histopathological picture was characterized by a m...

journal_title：Journal of cutaneous pathology

authors： Hofer PA,Jagell S

更新日期：1982-12-01 00:00:00

abstract：:Human hair follicles (HF) and sebaceous glands (SG) were assessed for the presence and distribution of the cytochrome P-450-aromatase (AR) and 3B-hydroxysteroid dehydrogenase (3B-HSD) enzymes. Immunohistochemical methods were used to examine both enzymes in male and female human skin specimens at various ages and diff...

journal_title：Journal of cutaneous pathology

authors： Sawaya ME,Penneys NS

更新日期：1992-08-01 00:00:00

abstract：:Antibodies reactive with S100 protein are useful markers in a diagnostic immunohistochemistry laboratory dealing with cutaneous tumors. However, S100 protein is not a single protein but instead a group of S100 proteins with diverse functions. S100 proteins constitute a family of acidic calcium-binding proteins that ar...

journal_title：Journal of cutaneous pathology

authors： McNutt NS

更新日期：1998-11-01 00:00:00

abstract：:A tumor of 60 years' duration overlying the sternum of an 87-year-old woman is described. Histologically, the tumor was composed of lobules and cords of epithelial cells with finely granular, eosinophilic cytoplasm. The epithelial nests were floating in large pools of mucinous stroma, separated by thin fibrovascular s...

journal_title：Journal of cutaneous pathology

authors： Sakamoto F,Ito M,Matumura G,Sato Y,Kimura S

更新日期：1991-04-01 00:00:00

abstract：:A patient with chronic myelocytic leukemia (CML) in blast transformation with extensive involvement of the skin is reported. The leukemic infiltrates consisted of blasts with lymphoblastoid morphology which were positive for terminal deoxynucleotidyl transferase (TdT) by fluorescent assay. The infiltrates rapidly reso...

journal_title：Journal of cutaneous pathology

authors： Ansell JE,Bhawan J,Pechet L

更新日期：1980-10-01 00:00:00

abstract：:Fundamental to our understanding of skin diseases and their presentation is an understanding of the pattern of their development. When we have established the molecular basis of their development we will be in a much better position to control and treat such diseases. The homeobox genes are a family of regulatory prot...

journal_title：Journal of cutaneous pathology

authors： Brown WM,Stenn KS

更新日期：1993-08-01 00:00:00

abstract：:We report a 2-year-old girl with developmental delay who, from the age of 1 year, developed perniotic lesions of the hands and feet initially diagnosed as chilblain lupus. Histological examination showed features of epidermal necrosis with intraepidermal bulla formation, interface dermatitis, lymphocytic vasculitis wi...

journal_title：Journal of cutaneous pathology

authors： Kolivras A,Aeby A,Crow YJ,Rice GI,Sass U,André J

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. OBJECTIVE:To study GATA3 expres...

journal_title：Journal of cutaneous pathology

authors： Llamas-Velasco M,Pérez-Gónzalez YC,Daudén E,Rütten A

更新日期：2018-05-01 00:00:00

abstract：:A 31 year old Indian woman presented with bilateral axillary masses that became noticeable with the onset of puberty. The masses exhibited similar consistency to the adjacent normal breast tissue but lacked an associated nipple complex. The clinical impression was lipoma; however, mammography, ultrasonography and skin...

journal_title：Journal of cutaneous pathology

authors： Ghosn SH,Khatri KA,Bhawan J

更新日期：2007-12-01 00:00:00

abstract：:Fifteen halo nevi were stained for the presence of S100 protein by an unlabelled antibody peroxidase-antiperoxidase method. S100 protein was clearly identifiable within nevus cell nests in the inflammatory infiltrate. The presence of this substance helped to identify nevus cells in dense inflammatory infiltrates and c...

journal_title：Journal of cutaneous pathology

authors： Penneys NS,Mayoral F,Barnhill R,Ziegels-Weissman J,Nadji M

更新日期：1985-02-01 00:00:00

abstract：:Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patie...

journal_title：Journal of cutaneous pathology

authors： Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Cicatricial forms of alopecia, including lichen planopilaris (LPP) and discoid lupus erythematosus (DLE), may present with overlapping clinical features. In such cases, histopathological examination may provide key information for resolving the differential diagnosis. Optimally, microscopical analysis for al...

journal_title：Journal of cutaneous pathology

authors： Nguyen JV,Hudacek K,Whitten JA,Rubin AI,Seykora JT

更新日期：2011-05-01 00:00:00

abstract：:Sebaceous gland neoplasms such as adenoma, epithelioma, and carcinoma are uncommon cutaneous tumors. Although sporadic, their occurrence is clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous gl...

journal_title：Journal of cutaneous pathology

authors： Abbas O,Mahalingam M

更新日期：2009-06-01 00:00:00

abstract：:We describe the case of a cutaneous symplastic leiomyoma in a 37-year-old woman who presented with a 4-year history of a painful slow growing lesion on the left upper arm. The lesion was excised and subjected to histological examination. A poorly circumscribed lesion was seen in the dermis composed of spindle shaped c...

journal_title：Journal of cutaneous pathology

authors： Usmani N,Merchant W,Yung A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The lack of highly specific clinical and histopathological criteria has contributed to the delay in diagnosis of subungual melanoma in situ in its early stages. METHODS:Eighteen cases of subungual melanoma in situ, the largest series reported to date, were analyzed to characterize the clinical and histopath...

journal_title：Journal of cutaneous pathology

authors： Park SW,Jang KT,Lee JH,Park JH,Kwon GY,Mun GH,Lee DY,Lee JB,Park KK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation which diagnosis can be challenging. Herein we want to describe the clinicopathological spectrum of findings in five cases of EED. METHODS:We retrospectively analyzed five cases in a single institution collected over a ...

journal_title：Journal of cutaneous pathology

authors： Sardiña LA,Jour G,Piliang MP,Bergfeld WF

更新日期：2019-02-01 00:00:00