Leukemia cutis in blastic transformation of chronic myelocytic leukemia: TdT positive blasts and response to vincristine and prednisone.

abstract：:Extramedullary hematopoiesis (EMH) in adults is a rare event, usually associated with myeloid disorders, and can be the first sign of chronic myelomonocytic leukemia. We report a case of EMH presenting as a hemorrhagic panniculitis in a patient who did not apparently present any myeloid disorders. The patient received...

journal_title：Journal of cutaneous pathology

authors： Gallo G,Bigliardi S,Cesinaro AM

更新日期：2019-10-01 00:00:00

abstract：:We studied the degenerative "ancient" changes in 19 cases of benign cutaneous schwannoma (BCS). Using conventional and immunohistochemical stains, we found (a) degenerative changes in 15 of 19 BCS; (b) prominent vascular abnormalities in 11 of 15 BCS; and (c) cytologic atypia in 15 of 19 BCS, without mitotic figures. ...

journal_title：Journal of cutaneous pathology

authors： Argenyi ZB,Balogh K,Abraham AA

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Fibrofolliculomas and trichodiscomas are benign dermal neoplasms that likely derive from the mantle of the hair follicle and can occur sporadically or in association with Birt-Hogg-Dube syndrome (BHDS). Little is known about the pathogenesis and immunophenotypic properties of these entities. METHODS:We inve...

journal_title：Journal of cutaneous pathology

authors： Collins GL,Somach S,Morgan MB

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This...

journal_title：Journal of cutaneous pathology

authors： Im M,Kim DH,Park JS,Chung H,Lee Y,Kim CD,Seo YJ,Lee JH

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma, but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations. METHODS:We identified three severely dysplastic nevi, one atypical intra...

journal_title：Journal of cutaneous pathology

authors： Parekh V,Sobanko J,Miller CJ,Karakousis G,Xu W,Letrero R,Elenitsas R,Xu X,Elder DE,Amaravadi R,Schuchter LM,Nathanson KL,Wilson MA,Chu EY

更新日期：2019-03-01 00:00:00

abstract：:The arrector pili (AP) muscle is a small band of smooth muscle that attaches proximally to the bulge area of the pilosebaceous apparatus in the reticular dermis and extends up toward the epidermis. The distal anatomy of the AP and the anchorage mechanism allowing hair erection have not been previously described. Integ...

journal_title：Journal of cutaneous pathology

authors： Mendelson JK,Smoller BR,Mendelson B,Horn TD

更新日期：2000-02-01 00:00:00

abstract：:Deep wrinkles of 6 elderly people were investigated using electron microscopy. There were ultrastructural differences in the elastotic changes between the area of the wrinkle and the surrounding areas. Elastic fibers containing electron-dense inclusions were mostly seen in the upper dermis of the wrinkled area and wer...

journal_title：Journal of cutaneous pathology

authors： Tsuji T

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas. METHODS:To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions. RESULTS:Me...

journal_title：Journal of cutaneous pathology

authors： Wu H,Barusevicius A,Babb J,Klein-Szanto A,Godwin A,Elenitsas R,Gelfand JM,Lessin S,Seykora JT

更新日期：2005-02-01 00:00:00

abstract：:The distribution of desmoglein, plakoglobin, E-cadherin, and beta-catenin in the peri-lesional and lesional skin of Hailey-Hailey disease, Darier's disease, and pemphigus vulgaris was examined by immunoelectron microscopy. In the peri-lesional skin, the immunolabeling of these desmosomal components was localized to de...

journal_title：Journal of cutaneous pathology

authors： Tada J,Hashimoto K

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a non-infectious, autoimmune, chronic ulcer of the skin, often co-existing with inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) have been implicated as mediators of tissue destruction in chronic cutaneous and intestinal wounds. METHODS:Twenty-four skin biopsie...

journal_title：Journal of cutaneous pathology

authors： Bister V,Mäkitalo L,Jeskanen L,Saarialho-Kere U

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Although a range of cytomegalovirus (CMV)-induced cutaneous manifestations is described in AIDS patients, skin involvement in immunocompromised patients is rare, and intraneural CMV inclusions or CMV neuritis has not been documented in skin biopsies. METHODS AND RESULTS:Cutaneous biopsies of CMV lesions wer...

journal_title：Journal of cutaneous pathology

authors： Ramdial PK,Dlova NC,Sydney C

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells. It has been postulated to be an important factor in homing of lymphocytes to the skin because of its function ...

journal_title：Journal of cutaneous pathology

authors： Magro CM,Dyrsen ME

更新日期：2008-11-01 00:00:00

abstract：:Mucinous cutaneous adnexal tumors are an uncommon occurrence. We describe three cases of mucinous hidradenoma characterized by diffuse and prominent mucinous cell proliferation and discuss the relevant literature. The patients (two men and one woman) ranged in age from 32 to 72 years. The lesions were completely excis...

journal_title：Journal of cutaneous pathology

authors： Goh SG,Carr R,Dayrit JF,Calonje E

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Myxoid liposarcoma typically presents as a deep-seated mass in the lower extremity of adults. Presentation as a primary subcutaneous tumor is rare. Here we discuss clinicopathologic characteristics of three such cases and their differential diagnosis to alert dermatopathologists to this unusual clinical pres...

journal_title：Journal of cutaneous pathology

authors： Buehler D,Marburger TB,Billings SD

更新日期：2014-12-01 00:00:00

abstract：:The number of epithelial cells per unit volume of tissue (NV) and the relative volume (VV) occupied by the spinous and basal layers of X-irradiated and non-irradiated rat-tail epidermis were studied using techniques of stereologic cytology. By a simple calculation, the absolute volumes of basal and spinous keratinocyt...

journal_title：Journal of cutaneous pathology

authors： Klein-Szanto AJ,De Rey BM,Cabrini RL

更新日期：1977-01-01 00:00:00

abstract：:The present study was undertaken to characterize further the structure and function of cutaneous nerves which we have previously shown to associate with skin immune cells (Hosoi et al., Nature 1993: 363:159). Ultrastructurally, axons were prominent within the superficial dermis and epidermis in neonatal murine skin, b...

journal_title：Journal of cutaneous pathology

authors： Egan CL,Viglione-Schneck MJ,Walsh LJ,Green B,Trojanowski JQ,Whitaker-Menezes D,Murphy GF

更新日期：1998-01-01 00:00:00

abstract：:Cutaneous mastocytosis is a disease characterized by the infiltration and proliferation of mast cells in the skin. In children, the most common form of presentation is urticaria pigmentosa, while the diffuse cutaneous bullous mastocytosis is one of the rarest subtypes seen. The aim of this paper is to present a case o...

journal_title：Journal of cutaneous pathology

authors： Slavescu KC,Chiorean R,Danescu S,Bota M,Rogojan L,Baican A

更新日期：2016-03-01 00:00:00

abstract：:Cutaneous syncytial myoepithelioma is a recently described rare tumor of the dermis. It is derived and composed purely of myoepithelial cells and shows a characteristic syncytial growth pattern of neoplastic cells with little intervening stroma and no recognizable ductal structures. It represents a diagnostic challeng...

journal_title：Journal of cutaneous pathology

authors： Alomari AK,Brown N,Andea AA,Betz BL,Patel RM

更新日期：2017-10-01 00:00:00

abstract：:A 35-year-old woman was examined because of a symptomless multiple annular eruption. The lesion consisted of rings of closely set, smooth, firm papules that were brown in color. Hemosiderotic histiocytoma was diagnosed by light and electron microscopy. Ultrastructurally, the lesion consisted of fibroblastic and histio...

journal_title：Journal of cutaneous pathology

authors： Saga K

更新日期：1981-06-01 00:00:00

abstract：:The histogenetic relationship amongst various dendritic cells of the dermis which may express markers including factor XIIIa (FXIIIa) or CD34 remains unclear. In this study we utilized a sensitive indirect immunoperoxidase staining technique to identify CD34 and FXIIIa, as well the monocyte/macrophage markers KP-1 and...

journal_title：Journal of cutaneous pathology

authors： Altman DA,Nickoloff BJ,Fivenson DP

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Psoriasis vulgaris is a common chronic inflammatory dermatosis. Disorders in keratinocyte proliferation, differentiation, inflammation and immune dysregulation are the major factors implicated in the pathogenesis of psoriasis vulgaris. METHODS:The study was performed in skin specimens of 25 patients with ps...

journal_title：Journal of cutaneous pathology

authors： Doger FK,Dikicioglu E,Ergin F,Unal E,Sendur N,Uslu M

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Becker nevus (BN) is a unilateral, hairy, pigmented cutaneous hamartoma that frequently appears in adolescence. Several features of BN suggest that increased androgen sensitivity plays a role in its pathogenesis. There have been only a few studies of histopathologic and immunohistochemical characteristics of...

journal_title：Journal of cutaneous pathology

authors： Kim YJ,Han JH,Kang HY,Lee ES,Kim YC

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Nestin is one of the intermediate filaments that are expressed in proliferating neural progenitor cells during development of the central nervous system (CNS) and peripheral nervous system. Postnatal re-expression of the protein occurs mainly under pathological conditions, including injury and neoplasia. In ...

journal_title：Journal of cutaneous pathology

authors： Brychtova S,Fiuraskova M,Hlobilková A,Brychta T,Hirnak J

更新日期：2007-05-01 00:00:00

abstract：:Verrucous hemangioma represents a rare congenital vascular proliferation that may be mistaken for angiokeratoma. Histopathological examination of a deep biopsy is necessary to confirm the diagnosis of verrucous hemangioma based on its involvement of the deep dermis and subcutaneous tissue. We present two cases of verr...

journal_title：Journal of cutaneous pathology

authors： Clairwood MQ,Bruckner AL,Dadras SS

更新日期：2011-09-01 00:00:00

abstract：AIM:In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under-recognized that scabies can also mimic Langerhans cell histiocytosis. METHODS:Sixteen examples of scabies were reviewed histologically and ...

journal_title：Journal of cutaneous pathology

authors： Bhattacharjee P,Glusac EJ

更新日期：2007-09-01 00:00:00

abstract：:A 31 year old Indian woman presented with bilateral axillary masses that became noticeable with the onset of puberty. The masses exhibited similar consistency to the adjacent normal breast tissue but lacked an associated nipple complex. The clinical impression was lipoma; however, mammography, ultrasonography and skin...

journal_title：Journal of cutaneous pathology

authors： Ghosn SH,Khatri KA,Bhawan J

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Pemphigoides gestationis (PG) is a blistering disorder of pregnancy caused by antibodies against basement membrane proteins. They are directed against the 180 kD bullous pemphigoid antigen (BPAg2), towards the epitopes within the NC 16A domain. There are many similarities between pemphigoid gestationis and b...

journal_title：Journal of cutaneous pathology

authors： Patton T,Plunkett RW,Beutner EH,Deng JS,Jukic DM

更新日期：2006-04-01 00:00:00

abstract：:A 57-year-old woman with cutaneous mastocytosis of 23 years duration developed a hyperpigmented abdominal plaque composed of confluent indurated papules that enlarged for a period of 1 year to 12 x 8 cm. Biopsy showed dermal infiltration by closely packed spindle-shaped mast cells, fibroblasts, collagen, and scattered...

journal_title：Journal of cutaneous pathology

authors： Wood C,Sina B,Webster CG,Kurgansky D,Drachenberg CB,Reedy EA

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Some examples of Bowen disease lack the characteristic broad parakeratosis making their histopathologic diagnosis particularly difficult in small and incomplete biopsies. MATERIALS AND METHODS:The archives of our dermatopathology laboratory were searched for cases of Bowen disease with >75% orthokeratosis (...

journal_title：Journal of cutaneous pathology

authors： Idriss MH,Misri R,Böer-Auer A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:It is not clear why melanocyte disappearance occurs without fibrotic evolution in halo nevus and with fibrotic evolution in regressing melanoma. METHODS:Six halo nevi, seven regressing primary melanomas, and seven primary melanoma (PM) without regression were studied using immunohistochemistry for the pheno...

journal_title：Journal of cutaneous pathology

authors： Moretti S,Spallanzani A,Pinzi C,Prignano F,Fabbri P

更新日期：2007-04-01 00:00:00