Abstract:
:Cutaneous mastocytosis is a disease characterized by the infiltration and proliferation of mast cells in the skin. In children, the most common form of presentation is urticaria pigmentosa, while the diffuse cutaneous bullous mastocytosis is one of the rarest subtypes seen. The aim of this paper is to present a case of diffuse bullous mastocytosis with detection of IgM deposits at dermo-epidermal junction using direct immunofluorescence (DIF) microscopy. The diagnosis of diffuse bullous mastocytosis is a challenge, and DIF microscopy is necessary in order to exclude an autoimmune bullous disorder. However, IgM deposits at dermo-epidermal junction can be nonspecific, being found in a variety of skin disorders. A 6-month-old girl presented with bullous lesions and erosions on the scalp and the trunk. During hospitalization, further bullous lesions appeared, along with generalized erythrodermia. Skin biopsy revealed aspects of urticaria pigmentosa. Taking into account the clinical findings, the case was enclosed as bullous mastocytosis. Treatment included the avoidance of trigger factors, and administration of antihistamines along with a short-term course of systemic steroids. The evolution was favorable, with remission of the existing lesions and without occurrence of new ones.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Slavescu KC,Chiorean R,Danescu S,Bota M,Rogojan L,Baican Adoi
10.1111/cup.12635subject
Has Abstractpub_date
2016-03-01 00:00:00pages
263-9issue
3eissn
0303-6987issn
1600-0560journal_volume
43pub_type
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
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journal_title:Journal of cutaneous pathology
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pub_type: 杂志文章
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更新日期:1993-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-07 00:00:00
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journal_title:Journal of cutaneous pathology
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