Degenerative ("ancient") changes in benign cutaneous schwannoma. A light microscopic, histochemical and immunohistochemical study.

abstract：:Bullous pemphigoid (BP) antigen and alpha 6 integrin are hemidesmosome-associated glycoproteins of basal keratinocytes. In this work, the immunoreactivity of antibodies to BP and to alpha 6 in salt- or dispase-split human skin, and in 46 biopsy specimens of various genetic and autoimmune bullous dermatoses taken from ...

journal_title：Journal of cutaneous pathology

authors： Kanitakis J,Zambruno G,Vassileva S,Giannetti A,Thivolet J

更新日期：1992-10-01 00:00:00

abstract：:Two cases of tubular apocrine adenoma were studied by light, histochemical, and electron microscopic methods. This benign apocrine hamartoma must be considered in the classification of appendage tumors, particularly those associated with organoid epithelial nevus, and may be confused with metastatic adenocarcinoma. Th...

journal_title：Journal of cutaneous pathology

authors： Umbert P,Winkelmann RK

更新日期：1976-01-01 00:00:00

abstract：:Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical...

journal_title：Journal of cutaneous pathology

authors： Dunn A,Broadfoot BG,Hunt J,Kaley JR,Atiq O,Gutta NB,Wang X,Gardner JM,Shalin SC

更新日期：2018-03-01 00:00:00

abstract：:Claudins are a family of transmembrane proteins involved in cell-to-cell adhesion and are believed to be the main component of tight junctions. Recent studies have suggested that some metastatic solid tumors lack claudin expression. It is unknown whether claudins play a role in cutaneous melanoma. Immunohistochemical ...

journal_title：Journal of cutaneous pathology

authors： Cohn ML,Goncharuk VN,Diwan AH,Zhang PS,Shen SS,Prieto VG

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging. An appropriate immunohistochemical panel may help to differentiate these lesions. METHODS:To determine the distribution and use of several immunostains...

journal_title：Journal of cutaneous pathology

authors： Sramek B,Lisle A,Loy T

更新日期：2008-07-01 00:00:00

abstract：:Superficial acral fibromyxoma (SAFM) is an uncommon mesenchymal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant n...

journal_title：Journal of cutaneous pathology

authors： Kara Polat A,Gore Karaali M,Turgut Erdemir AV,Koku Aksu AE,Leblebici C,Gurel MS

更新日期：2018-06-01 00:00:00

abstract：:The basal cell adhesion molecule (B-CAM) is a 90-kD cell surface glycoprotein with a characteristic immunoglobulin domain structure. The pattern of B-CAM expression in cultured cells suggests that the molecule is associated with a substrate-adherent growth pattern in some lineages. We investigated the expression of B-...

journal_title：Journal of cutaneous pathology

authors： Bernemann TM,Podda M,Wolter M,Boehncke WH

更新日期：2000-03-01 00:00:00

abstract：:Clinical and histologic features of 44 invasive squamous cell carcinomas of the lip treated by surgical excision were correlated with metastases and survival. Age, diameter, ulceration, grade, depth of invasion, muscle invasion, mitotic rate, lymphatic-vascular invasion, and tumor infiltrating lymphocytes were evaluat...

journal_title：Journal of cutaneous pathology

authors： Stein AL,Tahan SR

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum (MC) is a Molluscipox virus infection of keratinocytes with hyperplasia and intracytoplasmic inclusions - the molluscum bodies (MBs). Few papers address cytokeratins (K) profile in MC, mainly focusing terminal keratinization process. METHODS:Forty-one MC lesions were subjected to immun...

journal_title：Journal of cutaneous pathology

authors： Callegaro CF,Sotto MN

更新日期：2009-12-01 00:00:00

abstract：:Biologic therapies targeting tumor necrosis factor (TNF)-alpha have become a mainstay in the management of a number of autoimmune diseases. We report a series of adverse skin eruptions in six patients (four females, two males, age: 21-58 years, mean: 39) receiving 4 months to 10 years (mean 3.1 years) of anti-TNF-alph...

journal_title：Journal of cutaneous pathology

authors： Hawryluk EB,Linskey KR,Duncan LM,Nazarian RM

更新日期：2012-05-01 00:00:00

abstract：:In seven patients suffering from lichen planus (LP) light- and electron-microscopic 3H-thymidine (3HT) labeling studies were performed and the following results were obtained. 1. Using the light-microscope, a large number of 3HT labeled cells can be observed in the dermal infiltrate of LP. Most of the labeled nuclei b...

journal_title：Journal of cutaneous pathology

authors： Ebner H,Jurecka W

更新日期：1977-09-01 00:00:00

abstract：:We report a 20-year-old male patient with an atypical Spitz tumor, located in the dorsal aspect of his left hand, and a positive sentinel axillary lymph node. After lymphadenectomy, 1 of 23 non-sentinel lymph nodes excised was found to contain small multiple deposits of large spindle atypical melanocytes. Reviewing th...

journal_title：Journal of cutaneous pathology

authors： Urso C,Borgognoni L,Doria M,Tinacci G,Zini E

更新日期：2009-05-01 00:00:00

abstract：:In the past decades, the incidence of melanoma has been reported to rise in epidemic proportions. The chief reason for that pseudo-epidemic is improved criteria for diagnosis that allow melanomas to be recognized far more accurately and at earlier stages. The rising number of melanomas diagnosed has resulted in increa...

journal_title：Journal of cutaneous pathology

authors： Weyers W

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Distinguishing an irritated seborrheic keratosis (ISK) from a squamous cell carcinoma in situ (SCCIS) can occasionally be challenging, both histologically and clinically. The purpose of this study was to determine if an immunohistochemical profile of select markers can aid in differentiating these two entiti...

journal_title：Journal of cutaneous pathology

authors： Richey JD,Deng AC,Dresser K,O'Donnell P,Cornejo KM

更新日期：2018-08-01 00:00:00

abstract：:Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woma...

journal_title：Journal of cutaneous pathology

authors： Cohen PR,Prieto VG

更新日期：2010-08-01 00:00:00

abstract：:Pigmented extramammary Paget disease (PEMPD) is a rare intraepithelial carcinoma which can clinically resemble other pigmented neoplasms. Similarities to melanoma on dermoscopy, histopathology, and reflectance confocal microscopy (RCM) increase the risk of misdiagnosis and, consequently, mismanagement. Here, we descri...

journal_title：Journal of cutaneous pathology

authors： Chuchvara N,Reilly C,Haroon A,Wassef C,Maghari A,Rao B

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Although a range of cytomegalovirus (CMV)-induced cutaneous manifestations is described in AIDS patients, skin involvement in immunocompromised patients is rare, and intraneural CMV inclusions or CMV neuritis has not been documented in skin biopsies. METHODS AND RESULTS:Cutaneous biopsies of CMV lesions wer...

journal_title：Journal of cutaneous pathology

authors： Ramdial PK,Dlova NC,Sydney C

更新日期：2002-08-01 00:00:00

abstract：:The three-dimensional morphology of six dermatofibromas was studied by scanning electron microscopy. Hypertrophic epidermal ridges covered with large keratinized cells overlay each dermal lesion. Small collagenous fibers in the tumors contrasted with the bundles of much larger collagenous fibers in the normal dermis p...

journal_title：Journal of cutaneous pathology

authors： Wilborn WH,Montes LF

更新日期：1979-08-01 00:00:00

abstract：:A histologically unique condition of the sweat duct was found in a miliaria-like papular eruption on the extensor surfaces of extremities of a 41-year-old female patient. The hypertrophic epithelium of the sweat duct wall consisted of extensively vacuolated clear cells. There was mild hyperkeratosis around the sweat d...

journal_title：Journal of cutaneous pathology

authors： Izaki S,Kono E,Hirai A,Kitamura K

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:As the molecular mechanisms in melanoma chemoresistance remain unknown to date, we hypothesized these tumors to express the ATP-binding cassette (ABC) transporter G2 (ABCG2/MXR/BCRP1/ABCP1), a recently detected membrane transporter and putative stem-cell marker. Besides melanoma, we addressed the neuroendocr...

journal_title：Journal of cutaneous pathology

authors： Deichmann M,Thome M,Egner U,Hartschuh W,Kurzen H

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma, but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations. METHODS:We identified three severely dysplastic nevi, one atypical intra...

journal_title：Journal of cutaneous pathology

authors： Parekh V,Sobanko J,Miller CJ,Karakousis G,Xu W,Letrero R,Elenitsas R,Xu X,Elder DE,Amaravadi R,Schuchter LM,Nathanson KL,Wilson MA,Chu EY

更新日期：2019-03-01 00:00:00

abstract：:The lesions of nine patients with early striae distensae (SD) during puberty were examined by light and electron microscopy. Specific changes were seen in very early stage SD, and in clinically uninvolved skin 0.5 to 3 cm remote from the edge of the long axis of the SD lesions. Sequential changes of elastolysis accomp...

journal_title：Journal of cutaneous pathology

authors： Sheu HM,Yu HS,Chang CH

更新日期：1991-12-01 00:00:00

abstract：:A case of eosinophilic ulcer of the tongue is presented. Although the entity is rarely described, the distinctive histopathologic pattern featuring the remarkable presence of eosinophils in the superficial corium and in between muscle bundles, together with the benign clinical course, make a diagnosis possible. ...

journal_title：Journal of cutaneous pathology

authors： Borroni G,Pericoli R,Gabba P,Rosso R,Rabbiosi G

更新日期：1984-08-01 00:00:00

abstract：:An extensive congenital melanocytic nevus is described which, in its deeper portion, had striking neurofibromatous features. At the dermal subcutaneous junction, there were prominent subendothelial collections of nevus cells in large veins. Similar findings have been described in neurofibromatosis. The apparent relati...

journal_title：Journal of cutaneous pathology

authors： Santa Cruz DJ,Bashiti H

更新日期：1979-12-01 00:00:00

abstract：:Thirty-six Swedish patients with the recessively inherited Sjögren-Larsson syndrome (SLS) were examined by histopathologic and, in some cases, morphometric techniques. Skin biopsy specimens were taken on the volar side of the right forearm below the cubital fossa. The histopathological picture was characterized by a m...

journal_title：Journal of cutaneous pathology

authors： Hofer PA,Jagell S

更新日期：1982-12-01 00:00:00

abstract：:A 27-year-old woman developed many nodular lesions, ranging in diameter from 3 mm to 15 mm and clinically indistinguishable from dermatofibromas. Light microscopic examination showed large amounts of mucin, fibroblasts and histiocytes throughout the dermis. Electron microscopic study revealed wide electron lucent area...

journal_title：Journal of cutaneous pathology

authors： Zina AM,Bundino S

更新日期：1980-12-01 00:00:00

abstract：:An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. Biopsies were obtained from early evolving and late fibroproliferative lesions. Early lesions showed vasculitis and a massive dermal infiltrate composed mainly of neutrophils, h...

journal_title：Journal of cutaneous pathology

authors： Lee AY,Nakagawa H,Nogita T,Ishibashi Y

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun-exposed skin of older and usually immunosuppressed individuals. METHODS:Using data from NCI's SEER (Surveillance, Epidemiology, and End Results) Program from 1973 to 2006, we analyzed the demographics and ...

journal_title：Journal of cutaneous pathology

authors： Albores-Saavedra J,Batich K,Chable-Montero F,Sagy N,Schwartz AM,Henson DE

更新日期：2010-01-01 00:00:00

abstract：:This report deals with seven examples of an epithelial cyst for which we have found no proper designation in the classification of epithelial skin cysts. Clinically, the lesion is often hyperpigmented, located in mid-dermis and shows epidermoid keratinization. The cyst contains laminated keratin, many pigmented hair s...

journal_title：Journal of cutaneous pathology

authors： Mehregan AH,Medenica M

更新日期：1982-12-01 00:00:00

abstract：:LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral inje...

journal_title：Journal of cutaneous pathology

authors： Dolkar T,Trinidad CM,Nelson KC,Amaria RN,Nagarajan P,Torres-Cabala CA,Ivan D,Prieto VG,Tetzlaff MT,Curry JL,Aung PP

更新日期：2018-07-01 00:00:00