Factor XIIIa is expressed by fibroblasts in fibrovascular tumors.

Abstract:

:Factor XIIIa (FXIIIa), a blood and intracellularly produced coagulation factor, has been found in a variety of cell types including fibroblast-like mesenchymal cells, and has been shown to stimulate the proliferation of fibroblasts and some neoplastic cells in vitro. We have already shown that the dendritic fibroblasts composing the fibrous papule contain this factor. We hypothesized that histopathologically similar fibrovascular tumors may also express FXIIIa and, in this report, show that the large stellate fibroblasts found in acquired digital fibrokeratomas, angiofibromas (adenoma sebaceum of Pringle), and oral fibroma (oral fibrous hyperplasia) also express FXIIIa. We postulate that FXIIIa, possibly acting as a growth factor, may be a common denominator in the pathogenesis of these tumors. Another possibility is that these tumors may be the consequence of a local overproduction of FXIIIa in response to an, as yet, unidentified stimulus.

journal_name

J Cutan Pathol

authors

Nemeth AJ,Penneys NS

doi

10.1111/j.1600-0560.1989.tb00050.x

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

266-71

issue

5

eissn

0303-6987

issn

1600-0560

journal_volume

16

pub_type

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