Abstract：
:Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphologically suggestive of CaOx: 1 apocrine hidrocystoma and 2 tubular apocrine adenomas. The histologic features were examined in 3 cases. Clinical presentation summary included 2 males and 1 female, ages 53 to 74 years, with lesions located on the left cheek, inferior vertex scalp and the left eyebrow. All 3 cases showed polarizable, geometric, plate-like and fractured, colorless crystals within the lumens of the neoplasm. Of note, these crystals were seen only on the toluidine blue-stained section of Case #1, but were not present on the corresponding permanent section. We hypothesize that polarizable crystals may be present in sweat gland neoplasms more often than previously documented, but that they may often dissolve with routine processing, accounting for their rare visibility. We highlight this rare finding, and suggest that it may be underreported. We only noted this finding in benign apocrine tumors; further investigation would be necessary to determine whether these crystals are also seen in other cutaneous adnexal neoplasms.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Johnson G,Gardner JM,Shalin SCdoi
10.1111/cup.12962subject
Has Abstractpub_date
2017-08-01 00:00:00pages
698-702issue
8eissn
0303-6987issn
1600-0560journal_volume
44pub_type
abstract：:Myxofibrosarcomas (MFSs) are sarcomas most commonly seen in older patients. These are tumors of deep soft tissue seen in subcutaneous tissue and deep fascia, with frequent muscle involvement. These sarcomas are notorious for recurrences and progression to a higher grade with notable metastatic potential. They are very...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13432
更新日期：2019-05-01 00:00:00
abstract：:An 11-month-old female with focal dermal hypoplasia syndrome is described. Histologically, the skin lesions were characterized by a marked decrease in dermal connective tissue. Ultrastructurally, there were a number of fine filamentous structures measuring 5 to 70 nm within and between the bundles of collagen; most of...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1982.tb01063.x
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:Cardiac angiosarcoma is a rare tumor that has a predilection for middle-aged males and a marked predominance in the right atrium. The tumor may present abruptly with a fulminant clinical course. Initial presentation with metastatic disease is rare. Only one case has been reported of a patient who presented w...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2001.028005265.x
更新日期：2001-05-01 00:00:00
abstract：:Epidermal Langerhans cells (LC) from skin of clinically normal appearance in psoriatics were studied electron microscopically and compared with LC from the skin of healthy volunteers and from those with other dermatoses. Results show that LC from psoriatics display partly distinct cytoplasmic alterations. Moreover, ab...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1988.tb00566.x
更新日期：1988-12-01 00:00:00
abstract：BACKGROUND:Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a protein that plays an important role in mitochondrial and peroxisomal beta-oxidation of branched-chain fatty acid and bile acid intermediates. AMACR has been established as a valuable diagnostic marker for prostate cancer and has recently been ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01353.x
更新日期：2010-04-01 00:00:00
abstract：:Study of 18 patients with biopsy diagnoses of eosinophilic panniculitis revealed diverse patterns of systemic disease, including Wells' syndrome, vasculitis, atopy, and erythema nodosum as well as localized panniculitis. Significant associated diseases included psychiatric illness, 6 (drug dependency, 4); atopy, 5 (as...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1986.tb00455.x
更新日期：1986-02-01 00:00:00
abstract：:Cutaneous mixed tumors (MTs), also known as chondroid syringomas, usually arise as small nodules in the head and neck region. We describe an unusual case of a giant MT measuring 9 cm in its greatest diameter, occurring as a slowly growing pedunculated mass on the breast of a 74-year-old woman. Although MT may rarely o...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2008.01104.x
更新日期：2009-06-01 00:00:00
abstract：:Infundibulocystic basal cell carcinoma (IBCC) is a relatively recently described variant of basal cell carcinoma that is controversial and not universally accepted. Excluding cases of nevoid basal cell carcinoma syndrome, IBCC usually presents as a small, solitary, superficial lesion on the face of older persons. Ther...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2000.027006316.x
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Cryptococcosis and alternariosis are rare opportunistic infections often observed in immunocompromised patients. Because Cryptococcus and Alternaria are ubiquitous fungi found in soil, the presence of fungi in the dermis has to be observed on histological examination to confirm a real cutaneous, invasive, in...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1046/j.0303-6987.2001.00035.x
更新日期：2002-01-01 00:00:00
abstract：:The dermatological disorders associated with monoclonal gammopathies are clinically heterogeneous and may be divided into four groups with distinctive pathogenetic mechanisms (a) specific (infiltrative) disorders including primary and secondary cutaneous plasmacytoma and cutaneous lymphoplasmacytic infiltration of Wal...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.2007.00884.x
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Chronic graft-vs.-host disease (GVHD) is a severe and potentially fatal complication in patients after undergoing allogeneic stem cell transplant. This disease may be hard to diagnose as it has numerous cutaneous presentations. METHODS:We report four cases of patients seen at Stanford Hospital between Janua...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12640
更新日期：2016-03-01 00:00:00
abstract：:We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angioc...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.12885
更新日期：2017-03-01 00:00:00
abstract：:Electron microscopy of lentigines was performed to study the pigmentation abnormality in two children with LEOPARD syndrome. Giant melanosomes similar to those seen in café-au-lait spots of neurofibromatosis and nevus spilus were found in a lentigine from one of our cases. Our results show that "spherical granular mel...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1976.tb00865.x
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Mucocutaneous depositions of various metals such as silver, lead, gold, arsenic, mercury, iron, and bismuth have been previously published. Heavy metal deposition typically occurs in the setting of either prolonged topical application to intact skin, topical application to eroded or ulcerated skin, as a resu...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2002.291008.x
更新日期：2002-11-01 00:00:00
abstract：:Langerhans cell histocytosis (LCH) and Erdheim-Chester disease are two rare histiocytic disorders. Their occurrence in the same patient is more infrequent, but has been described. We report a case of a 38-year-old woman who presented with a diagnosis of single system cutaneous LCH. Subsequently, she developed multiple...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12636
更新日期：2016-03-01 00:00:00
abstract：:Histologic, immunologic and electron microscopic studies were performed in a patient with transient acantholytic dermatosis which involved oral mucosa. Hitologic and electron microscopic findings were almost identical in both cutaneous and mucous membrane lesions, and these were similar to pemphigus vulgaris; suprabas...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1978.tb00933.x
更新日期：1978-02-01 00:00:00
abstract：:Cutaneous mastocytosis is a disease characterized by the infiltration and proliferation of mast cells in the skin. In children, the most common form of presentation is urticaria pigmentosa, while the diffuse cutaneous bullous mastocytosis is one of the rarest subtypes seen. The aim of this paper is to present a case o...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12635
更新日期：2016-03-01 00:00:00
abstract：:Free-living amebae are ubiquitous in our environment, but rarely cause cutaneous infection. Balamuthia mandrillaris has a predilection for infecting skin of the central face. Infection may be restricted to the skin or associated with life-threatening central nervous system (CNS) involvement. We report a case of a 91-y...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.12748
更新日期：2016-10-01 00:00:00
abstract：:Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon, which is even rarer in the context of metastatic breast carcinoma. Different mechanisms of SR are still under debate, including immune-mediated response. We herein report a case of the SR of intralymphatic cutaneous metastases o...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13694
更新日期：2020-08-01 00:00:00
abstract：:The histological picture of molluscum contagiosum (MC) is well known: the epidermis grows down into the dermis as multiple, closely packed pear-shaped lobules. The epithelial cells of the outermost layers and the horny layer display typical molluscum bodies. In this paper, we describe an unusual case of MC in a cystic...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1985.tb01618.x
更新日期：1985-04-01 00:00:00
abstract：:We report a case of disseminated Trichosporon asahii in a patient on systemic antifungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid-Schiff and Gomori methenamine silver confirmed t...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13397
更新日期：2019-02-01 00:00:00
abstract：:We report a new case of a Japanese man who developed a tubular apocrine adenoma in association with syringocystadenoma papilliferum. The differences in the histopathological and immunohistochemical findings in these 2 tumors are described. This is the first immunohistochemical study of tubular apocrine adenoma. ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1989.tb00047.x
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:Bullous pemphigoid (BP) is the most common type of subepidermal bullous disease. Direct immunofluorescence (DIF) is the gold standard for diagnosis, but it requires a fresh tissue specimen. This study was conducted to evaluate the accuracy of using immunohistochemical (IHC) analysis for the detection of C4d ...
journal_title：Journal of cutaneous pathology
pub_type： 临床试验,杂志文章
doi：10.1111/cup.13490
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:It is not clear why melanocyte disappearance occurs without fibrotic evolution in halo nevus and with fibrotic evolution in regressing melanoma. METHODS:Six halo nevi, seven regressing primary melanomas, and seven primary melanoma (PM) without regression were studied using immunohistochemistry for the pheno...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00616.x
更新日期：2007-04-01 00:00:00
abstract：:A patient with chronic myelocytic leukemia (CML) in blast transformation with extensive involvement of the skin is reported. The leukemic infiltrates consisted of blasts with lymphoblastoid morphology which were positive for terminal deoxynucleotidyl transferase (TdT) by fluorescent assay. The infiltrates rapidly reso...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1980.tb01199.x
更新日期：1980-10-01 00:00:00
abstract：BACKGROUND:Melanocytic nevi from the genitalia are uncommon. Nevi on the vulva are much better described than nevi on male genitalia. To our knowledge, a systematic study of preputial melanocytic nevi has not been reported. OBJECTIVE:To investigate the frequency of clinically unapparent melanocytic nevi on a series of...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2008.01070.x
更新日期：2009-04-01 00:00:00
abstract：:Dermatomyositis, a connective tissue disease syndrome where antibodies to the endothelium of the microvasculature of the skin, muscle and lung are implicated in lesional propagation, is characterized by photodistributed erythema, heliotrope rash, Gottron's papules, muscle weakness and interstitial pulmonary fibrosis. ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2007.00767.x
更新日期：2008-01-01 00:00:00
abstract：:Large cell acanthoma (LCA) is an epidermal neoplasm whose nature has been variously explained. Though frequently hyperpigmented, we describe for the first time an achromic case located on the dorsum of the right hand of a 83-year-old woman. This observation is largely inconsistent with one of the theories about the na...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1990.tb00079.x
更新日期：1990-06-01 00:00:00
abstract：:Benign lymphangioendothelioma is a rare locally infiltrative vascular neoplasm, presenting as a slow-growing, asymptomatic, reddish-violaceous plaque. Histopathologically, it is characterized by irregular and thin-walled vascular spaces, lined by a single and discontinuous layer of flat endothelial cells, dissecting d...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2012.01971.x
更新日期：2012-10-01 00:00:00
abstract：:Twenty-nine cases of histiocytic neoplasms, some resembling juvenile xanthogranuloma (JXG) and others resembling reticulohistiocytoma (RH), were evaluated. Immunohistochemical stains were performed. In this series, seven cases were identified that expressed S-100 protein positive cells. The S-100 positive cells were p...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.1998.tb01704.x
更新日期：1998-03-01 00:00:00
