Mucocutaneous pigmented macule as a result of zinc deposition.

Abstract:

BACKGROUND:Mucocutaneous depositions of various metals such as silver, lead, gold, arsenic, mercury, iron, and bismuth have been previously published. Heavy metal deposition typically occurs in the setting of either prolonged topical application to intact skin, topical application to eroded or ulcerated skin, as a result of either parenteral administration, or due to penetrating traumatic exposure. METHOD:We report a unique case of mucocutaneous pigmentation occurring in a snow skier after topical application of a zinc-containing sunblock. Formalin-fixed paraffin-embedded tissue was utilized for electron microscopy. RESULT:Backscatter electron imaging and energy dispersive spectroscopy revealed that the dominant metal present was zinc. CONCLUSIONS:Mucocutaneous deposition of metals is enhanced by damage to the surface epithelium. Metal-containing topical agents, although commonly used, may rarely result in a permanent pigmentary alteration. We believe similar cases of mucocutaneous deposition of zinc exist; however, as these may be currently misdiagnosed as amalgam tattoos, the true incidence of this disorder is presently undefined.

journal_name

J Cutan Pathol

authors

Greenberg JE,Lynn M,Kirsner RS,Elgart GW,Hanly AJ

doi

10.1034/j.1600-0560.2002.291008.x

keywords:

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

613-5

issue

10

eissn

0303-6987

issn

1600-0560

pii

cup291008

journal_volume

29

pub_type

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