Abstract：
:The arrector pili (AP) muscle is a small band of smooth muscle that attaches proximally to the bulge area of the pilosebaceous apparatus in the reticular dermis and extends up toward the epidermis. The distal anatomy of the AP and the anchorage mechanism allowing hair erection have not been previously described. Integrins are likely candidates mediating this attachment. Immunohistochemical techniques were used to determine the distribution of the following integrins: alpha1, alpha2, alpha3, alpha4, alpha5, alpha6 and beta1 as well as fibronectin. Frozen human scalp tissue was sectioned in traditional planes, obliquely and horizontally to visualize microanatomy in three dimensions. Histological examination revealed that the distal portions of smooth muscle fibers splay extensively between collagen bundles of the upper dermis. Integrin subunits alpha1, alpha5 and beta1 were expressed by the AP muscle. Analysis of the relative density of immunoreactivity in digitized sections revealed increased alpha5 subunit expression at the extracellular matrix (ECM)-muscle interface. These data suggest that anchorage of the AP muscle to the ECM is via alpha5beta1 integrin and alpha1beta1 integrin functions in muscle cell-cell adhesion. Extensive splaying of smooth muscle fibers may allow increased surface area contact between the ECM and smooth muscle cells expressing peripherally situated alpha5 integrin.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Mendelson JK,Smoller BR,Mendelson B,Horn TDdoi
10.1034/j.1600-0560.2000.027002061.xkeywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
61-6issue
2eissn
0303-6987issn
1600-0560journal_volume
27pub_type
杂志文章abstract：:A 31 year old Indian woman presented with bilateral axillary masses that became noticeable with the onset of puberty. The masses exhibited similar consistency to the adjacent normal breast tissue but lacked an associated nipple complex. The clinical impression was lipoma; however, mammography, ultrasonography and skin...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00713.x
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Chronic urticaria is a condition with many inciting factors and often presents a therapeutic challenge to clinicians. In addition to a central role for mast cells, an immune dysregulated state related to cytokine/chemokine alterations is increasingly being recognized. METHODS:Biopsies of chronic urticaria (...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12673
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Hypertrophic lichen planus (LP) is a variant of LP favoring the lower extremities and showing prominent epidermal hyperplasia and hyperorthokeratosis. Contrary to dogma that eosinophils are rare in LP and variants, we noticed that some cases of hypertrophic LP have eosinophils in the absence of drug history....
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12275
更新日期：2014-04-01 00:00:00
abstract：:A 59-year-old female with a cystic fibroepithelioma of Pinkus is presented. The clinical and histopathological features of this unusual variant of basal cell carcinoma are discussed. ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1991.tb00157.x
更新日期：1991-06-01 00:00:00
abstract：:Two collodion baby girls with disorder evolving into lamellar ichthyosis were followed by light and electron microscopy. Light microscopically, the neonatal colloidion skin was characterized by a thick compact stratum corneum which was PAS positive in its upper two thirds, by a thin stratum granulosum and by a non-aca...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1977.tb00924.x
更新日期：1977-12-01 00:00:00
abstract：:Recently, T-cell lymphoma localized to the subcutaneous tissue has been reported. We report the clinical, histologic, immunohistochemical, and molecular genetic findings in 6 patients who we believe had this peculiar T-cell lymphoma with its unique morphologic and clinical features. All patients presented with deep-se...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1994.tb00244.x
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Even though only 33 cases of Erythromelanosis follicularis faciei et colli (EFFC) have been reported around the world, there have been no quantitative clinicopathological studies yet. The purpose of this study is to examine quantitatively clinical and histopathological evaluations of EFFC using image analysi...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2001.028003160.x
更新日期：2001-03-01 00:00:00
abstract：:A 27-year-old woman developed many nodular lesions, ranging in diameter from 3 mm to 15 mm and clinically indistinguishable from dermatofibromas. Light microscopic examination showed large amounts of mucin, fibroblasts and histiocytes throughout the dermis. Electron microscopic study revealed wide electron lucent area...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1980.tb01206.x
更新日期：1980-12-01 00:00:00
abstract：:Apoptosis is a process found in many tissues by which devitalized cells are eliminated in an orderly manner. In skin, apoptosis occurs following sunburn, in Bowen's disease and in basal cell carcinoma. Scattered cells are observed in which the cytoplasm has become condensed and dyskeratotic. These dyskeratotic cells a...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1975.tb00208.x
更新日期：1975-01-01 00:00:00
abstract：:We report three new cases of neutrophilic eccrine hidradenitis associated with induction chemotherapy which resolves two major points. First, because two of our patients had testicular carcinoma; this firmly establishes that NEH is not exclusively seen in patients with acute myelogenous leukemia or Hodgkin's lymphoma ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1987.tb00499.x
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:Histiocytic sarcoma is an exceedingly rare malignant neoplasm composed of cells with a monocyte/macrophage phenotype. In the current nosology of histiocytic neoplasms, histiocytic sarcoma is separate from indeterminate cell histiocytosis, a generally benign disorder characterized by proliferation of a CD1a+ ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.0303-6987.2006.00453.x
更新日期：2006-06-01 00:00:00
abstract：:The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge. The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2010.01517.x
更新日期：2010-04-01 00:00:00
abstract：AIM:In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under-recognized that scabies can also mimic Langerhans cell histiocytosis. METHODS:Sixteen examples of scabies were reviewed histologically and ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00723.x
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Sebaceous tumors are adnexal neoplasms showing sebocytic differentiation. They range from benign to malignant and are associated with Muir-Torre syndrome (MTS). Several clinical and histopathological features associated with MTS have been described. Sebaceous tumors with an overlying cutaneous horn are extre...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12321
更新日期：2014-08-01 00:00:00
abstract：:Primary cutaneous extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) represents a monoclonal B-cell neoplasm that typically presents with papules, plaques or nodules. We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenot...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2011.01726.x
更新日期：2011-09-01 00:00:00
abstract：:Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphological...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.12962
更新日期：2017-08-01 00:00:00
abstract：:Extravasation of doxorubicin in skin and soft tissue causes necrosis and ulceration. These ulcers form slowly and heal with great difficulty. The cause of ulceration is not known. Histologic changes in two patients suggest that an exaggeration of interface dermatitis like epidermal changes may be responsible for epide...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1989.tb00032.x
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:Rare cases of a non-bullous neutrophilic dermatosis occurring in patients with lupus erythematosus (LE) have been reported, often as the presenting manifestation of the disease. METHODS:We reviewed hematoxylin and eosin-stained slides and obtained clinical information from four additional patients, two of w...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00559.x
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Cardiac angiosarcoma is a rare tumor that has a predilection for middle-aged males and a marked predominance in the right atrium. The tumor may present abruptly with a fulminant clinical course. Initial presentation with metastatic disease is rare. Only one case has been reported of a patient who presented w...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2001.028005265.x
更新日期：2001-05-01 00:00:00
abstract：:We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), a...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1990.tb00099.x
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:Scleroderma/morphea is characterized by expansion of the dermis with thickened collagen bundles and loss of CD34(+) dermal dendrocytes. Variable elastic fiber changes have been described, but to our knowledge, no systematic study of the elastic fiber pattern correlated with CD34 expression has been reported....
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01201.x
更新日期：2009-09-01 00:00:00
abstract：:Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed significant therapeutic benefit in patients with clinically advanced solid malignancies, including melanoma. However, immune-related adverse events (irAE) ar...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13150
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun-exposed skin of older and usually immunosuppressed individuals. METHODS:Using data from NCI's SEER (Surveillance, Epidemiology, and End Results) Program from 1973 to 2006, we analyzed the demographics and ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01370.x
更新日期：2010-01-01 00:00:00
abstract：:Although CD1a+ dendritic cells (DC) in cutaneous T-cell lymphomas (CTCL) have been well documented, the presence of large numbers of DC within lymphoid infiltrates can pose a diagnostic difficulty. We present a case of a 70-year-old man with a 3-year history of recurrent red papules and plaques on the extremities and ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00659.x
更新日期：2007-07-01 00:00:00
abstract：:We report a facial tumor that was proven to be a metastatic mesothelioma. The diagnosis was not established pre-mortem. The patient died shortly after the facial biopsy, and an autopsy revealed a large pleural-based mass which had the gross appearance typical of a mesothelioma. Electron microscopic examination of tiss...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1992.tb01602.x
更新日期：1992-12-01 00:00:00
abstract：:During the past decade, a group of cells located in the dermis and possessing a dendritic morphology have emerged from obscurity and become recognized as important members of the "dermal immune system". This group of cells is characterized by a considerable degree of immunophenotypic and functional heterogeneity. In t...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.1995.tb00753.x
更新日期：1995-10-01 00:00:00
abstract：:The authors have observed 15 examples of a distinctive fibrohistiocytic lesion in children and adolescents which they chose to designate as "atypical fibrous histiocytoma" (AFH). Patient ages ranged from 1 to 19 years (mean 9.3 yr.). Only two cases were encountered in the first year of life, but 7 were seen in childre...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1992.tb01362.x
更新日期：1992-08-01 00:00:00
abstract：:Cutaneous lesions of lupus erythematosus (LE) show a broad spectrum of clinicopathologic features. Histopathologically, besides typical patterns such as interface dermatitis, perivascular lymphocytic infiltrate and dermal mucin deposits, an involvement of the eccrine structures, especially the acrosyringium, may be ob...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01295.x
更新日期：2010-01-01 00:00:00
abstract：:The low-fat and fat-free spindle cell lipomas (SCLs) are rare and often mistaken for other benign and malignant morphological mimics, because of the fact that the diagnosis relies on its non-lipogenic component analysis. Here, we report the clinicopathological features of two oral SCLs (low-fat and fat-free variants)....
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/cup.13512
更新日期：2019-10-01 00:00:00
abstract：:Thirty cases of poorly differentiated carcinomas of the skin were examined for the expression of vimentin. All cases expressed cytokeratins; in addition, 12 cases were positive for vimentin. These were all non-reactive with antibodies to S100 protein, HMB45 and desmin. The finding of vimentin in poorly differentiated ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1992.tb01556.x
更新日期：1992-02-01 00:00:00
