Low-fat and fat-free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature.

abstract：BACKGROUND:Infection with parvovirus B19 (B19) has been associated with connective tissue disease (CTD) stigmata, namely, a systemic lupus erythematosus (SLE)-like illness, seronegative polyarthritis resembling rheumatoid arthritis, and vasculitis. The dermatopathology and pathogenetic basis of such B19-associated CTD-...

journal_title：Journal of cutaneous pathology

authors： Crowson AN,Magro CM,Dawood MR

更新日期：2000-11-01 00:00:00

abstract：:A histologically unique condition of the sweat duct was found in a miliaria-like papular eruption on the extensor surfaces of extremities of a 41-year-old female patient. The hypertrophic epithelium of the sweat duct wall consisted of extensively vacuolated clear cells. There was mild hyperkeratosis around the sweat d...

journal_title：Journal of cutaneous pathology

authors： Izaki S,Kono E,Hirai A,Kitamura K

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Fibrofolliculomas and trichodiscomas are benign dermal neoplasms that likely derive from the mantle of the hair follicle and can occur sporadically or in association with Birt-Hogg-Dube syndrome (BHDS). Little is known about the pathogenesis and immunophenotypic properties of these entities. METHODS:We inve...

journal_title：Journal of cutaneous pathology

authors： Collins GL,Somach S,Morgan MB

更新日期：2002-10-01 00:00:00

abstract：:A 60-year-old female and a 59-year-old male each presented with a solitary circumscribed patch of depressed skin of the right thenar palm and right sole, respectively. Both lesions were present for approximately 30 years without a history of trauma or other inciting incident. Histologically, the lesions showed a well-...

journal_title：Journal of cutaneous pathology

authors： Barry CI,Glusac EJ,Kashgarian M,Gwin K,McNiff JM

更新日期：2008-05-01 00:00:00

abstract：:Light and electron-microscopic studies were performed on the amelanotic and adjacent normal-appearing skin in patients with vitiligo. The amelanotic skin revealed complete loss of pigment and absence of melanocytes. In addition to severe degenerative changes of melanocytes, varying degree of damage was also seen in th...

journal_title：Journal of cutaneous pathology

authors： Bhawan J,Bhutani LK

更新日期：1983-06-01 00:00:00

abstract：:CD44, a family of closely related glycoproteins generated by alternative splicing, as well as the increased beta 1,6-branching of Asn-linked oligosaccharides (beta 1,6-branches), have been implicated in tumor progression and metastasis. We have investigated the expression of CD44 standard (CD44s), various CD44 splice ...

journal_title：Journal of cutaneous pathology

authors： Seelentag WK,Böni R,Günthert U,Futo E,Burg G,Heitz PU,Roth J

更新日期：1997-04-01 00:00:00

abstract：:Primary cutaneous extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) represents a monoclonal B-cell neoplasm that typically presents with papules, plaques or nodules. We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenot...

journal_title：Journal of cutaneous pathology

authors： Edinger JT,Lorenzo CR,Breneman DL,Swerdlow SH

更新日期：2011-09-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans is a low-grade sarcoma of the skin with well characterized clinical and histopathological features. The lesion frequently appears as a plaque on the trunk or on the extremities of middle-aged adults. Microscopically, the tumor is composed of monomorphous spindle cells arranged in storif...

journal_title：Journal of cutaneous pathology

authors： Diaz-Cascajo C,Weyers W,Borghi S

更新日期：1998-09-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. Lipomembranous panniculitis is a peculiar type of fat necrosis and has been rep...

journal_title：Journal of cutaneous pathology

authors： Almeida MS,Lima SC,Carvalho LL,Almeida JV,Santos LG,Rolim JR,Rocha TE

更新日期：2010-11-01 00:00:00

abstract：:Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin. In most cases, it arises in pre-existing benign eccrine spiradenoma. We report an additional case of malignant eccrine spiradenoma. The present case is of a 75-year-old man with malignant eccrine spiradenoma developed in the right sho...

journal_title：Journal of cutaneous pathology

authors： Ben Brahim E,Sfia M,Tangour M,Makhlouf R,Cribier B,Chatti S

更新日期：2010-04-01 00:00:00

abstract：:In seven patients suffering from lichen planus (LP) light- and electron-microscopic 3H-thymidine (3HT) labeling studies were performed and the following results were obtained. 1. Using the light-microscope, a large number of 3HT labeled cells can be observed in the dermal infiltrate of LP. Most of the labeled nuclei b...

journal_title：Journal of cutaneous pathology

authors： Ebner H,Jurecka W

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Chronic graft-vs.-host disease (GVHD) is a severe and potentially fatal complication in patients after undergoing allogeneic stem cell transplant. This disease may be hard to diagnose as it has numerous cutaneous presentations. METHODS:We report four cases of patients seen at Stanford Hospital between Janua...

journal_title：Journal of cutaneous pathology

authors： Park JH,Lester L,Kim J,Kwong BY

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:BRAF, a serine/threonine kinase, is a component of the retrovirus-associated sequence (RAS)-RAF-extracellular-regulated protein kinase (ERK)-MAP kinase signal transduction pathway mediating signals from RAS to ERK. The T1796A single point mutation in exon 15 of the BRAF gene has recently been reported in a h...

journal_title：Journal of cutaneous pathology

authors： Palmedo G,Hantschke M,Rütten A,Mentzel T,Hügel H,Flaig MJ,Yazdi AS,Sander CA,Kutzner H

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:The term spitzoid melanoma (SM) is reserved for a rare group of tumors with striking resemblance to Spitz nevus, often developing in children diagnosed in retrospect after the development of metastases. OBJECTIVES:To determine the biological significance of SM and to analyze the effectiveness of adjuvant ...

journal_title：Journal of cutaneous pathology

authors： Paradela S,Fonseca E,Pita S,Kantrow SM,Goncharuk VN,Diwan H,Prieto VG

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Expression of programmed death ligand 1 (PD-L1) by cutaneous squamous cell carcinomas has been shown to correlate with advanced disease and risk of metastasis. Lymphocyte activation gene 3 (LAG-3, or CD223) is an inhibitory receptor that interacts with the PD-L1 axis, which has been shown to be a marker of i...

journal_title：Journal of cutaneous pathology

authors： Wu S,Slater NA,Sayed CJ,Googe PB

更新日期：2020-10-01 00:00:00

abstract：:Two cases of tubular apocrine adenoma were studied by light, histochemical, and electron microscopic methods. This benign apocrine hamartoma must be considered in the classification of appendage tumors, particularly those associated with organoid epithelial nevus, and may be confused with metastatic adenocarcinoma. Th...

journal_title：Journal of cutaneous pathology

authors： Umbert P,Winkelmann RK

更新日期：1976-01-01 00:00:00

abstract：:Myxofibrosarcoma is one of the most common soft tissue sarcomas occurring in older adults. It can arise de novo or can be radiation induced, and the term myxofibrosarcoma was originally devised to encompass a spectrum of myxoid tumors with characteristics similar to malignant fibrous histiocytoma (MFH). Confusion exis...

journal_title：Journal of cutaneous pathology

authors： Bandino JP,Norton SA,Aldrich SL,Wisco OJ,Hodson DS,Murchland MR,Grande DJ

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells. It has been postulated to be an important factor in homing of lymphocytes to the skin because of its function ...

journal_title：Journal of cutaneous pathology

authors： Magro CM,Dyrsen ME

更新日期：2008-11-01 00:00:00

abstract：:Another histological variant of basal cell carcinoma (BCC) is described. This clear-cell variant appeared as a recurrent lesion on the back of an elderly man. Histological examination revealed that part of the tumor was composed of clear cells with faintly eosinophilic cytoplasm. Degenerative changes were present, alo...

journal_title：Journal of cutaneous pathology

authors： Oliver GF,Winkelmann RK

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:As the molecular mechanisms in melanoma chemoresistance remain unknown to date, we hypothesized these tumors to express the ATP-binding cassette (ABC) transporter G2 (ABCG2/MXR/BCRP1/ABCP1), a recently detected membrane transporter and putative stem-cell marker. Besides melanoma, we addressed the neuroendocr...

journal_title：Journal of cutaneous pathology

authors： Deichmann M,Thome M,Egner U,Hartschuh W,Kurzen H

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labeled as fibroblastic connective tissue nevus (FCTN). METHODS AND RESULTS:Total of 8 patients were male and 5 were female, ranging in age from 1 to 56 years. Lesions appeared ...

journal_title：Journal of cutaneous pathology

authors： Pennacchia I,Kutzner H,Kazakov DV,Mentzel T

更新日期：2017-10-01 00:00:00

abstract：:A giant cell fibroblastoma (GCF) presented in the subcutis of the breast in a 13-month-old girl which recurred 6 years later as a dermal and subcutaneous neoplasm whose patterns were in part GCF and spindle cells with a storiform configuration resembling dermatofibrosarcoma protuberans (DFSP). The issue remains unsett...

journal_title：Journal of cutaneous pathology

authors： Perry DA,Schultz LR,Dehner LP

更新日期：1993-10-01 00:00:00

abstract：:Nivolumab is a programmed cell death receptor-1 (PD-1) antibody used in the treatment of metastatic or unresectable melanoma. Cutaneous reactions are the most common adverse events reported with these agents and are rarely severe or life-threatening. Here we present a case report describing the clinicopathological fin...

journal_title：Journal of cutaneous pathology

authors： Vivar KL,Deschaine M,Messina J,Divine JM,Rabionet A,Patel N,Harrington MA,Seminario-Vidal L

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is associated with an increased risk of a second malignancy. METHODS:We conducted a retrospective clinicopathologic review of 12 patients with CLL/SLL who developed a second lymphoma in the skin. Demographic data, clinical information, and hi...

journal_title：Journal of cutaneous pathology

authors： Liu YA,Finn AJ,Subtil A

更新日期：2021-01-07 00:00:00

abstract：:A 35-year-old woman was examined because of a symptomless multiple annular eruption. The lesion consisted of rings of closely set, smooth, firm papules that were brown in color. Hemosiderotic histiocytoma was diagnosed by light and electron microscopy. Ultrastructurally, the lesion consisted of fibroblastic and histio...

journal_title：Journal of cutaneous pathology

authors： Saga K

更新日期：1981-06-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorder (PTLD) is a lymphoid proliferation that develops as a complication of solid organ or bone marrow transplants. PTLD limited to the skin is very rare. Plasmacytoma-like PTLD is an uncommon variant of monomorphic PTLD. Its presentation in the skin is extraordinary with very fe...

journal_title：Journal of cutaneous pathology

authors： Molina-Ruiz AM,Pulpillo A,Lasanta B,Zulueta T,Andrades R,Requena L

更新日期：2012-07-01 00:00:00

abstract：:Brooke-Spiegler syndrome represents an autosomal dominant disease characterized by the occurrence of multiple cylindromas, trichoepitheliomas and (sporadically) spiroadenomas. Patients with Brooke-Spiegler syndrome are also at risk of developing tumors of the major and minor salivary glands. Patients with Brooke-Spieg...

journal_title：Journal of cutaneous pathology

authors： Ponti G,Nasti S,Losi L,Pastorino L,Pollio A,Benassi L,Giudice S,Bertazzoni G,Veratti E,Azzoni P,Bianchi Scarrà G,Seidenari S

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Among the pigmented lesions with a central area of scar, we found a group of cases histologically characterized by striking architectural alteration of the melanocytic component, but with no cytological atypia and mitotically quiescent. The aim of the current study was to assess the biological nature of such...

journal_title：Journal of cutaneous pathology

authors： Fabrizi G,Pennacchia I,Pagliarello C,Massi G

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neoplasm, which is often associated with Merkel cell polyomavirus (MCPyV). Programmed death-1 (PD-1) and its ligand PD-L1 are key players of the tumor microenvironment (TME). METHODS:Fourteen paraffin-embedded tissue samples of MCC were stratified by their MCPyV ...

journal_title：Journal of cutaneous pathology

authors： Mitteldorf C,Berisha A,Tronnier M,Pfaltz MC,Kempf W

更新日期：2017-09-01 00:00:00

abstract：:Ten patients with traumatic alopecia (trichotillomania) were being investigated histologically and, in five of them, hairs from the affected scalp area were plucked out for direct microscopic examination. Some histologic features appear to be specific markers for traumatic alopecia: empty hair ducts, plucked out hair ...

journal_title：Journal of cutaneous pathology

authors： Lachapelle JM,Pierard GE

更新日期：1977-01-01 00:00:00