Histiocytic sarcoma with secondary involvement of the skin and expression of CD1a: evidence of indeterminate cell differentiation?

abstract：BACKGROUND:BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma, but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations. METHODS:We identified three severely dysplastic nevi, one atypical intra...

journal_title：Journal of cutaneous pathology

authors： Parekh V,Sobanko J,Miller CJ,Karakousis G,Xu W,Letrero R,Elenitsas R,Xu X,Elder DE,Amaravadi R,Schuchter LM,Nathanson KL,Wilson MA,Chu EY

更新日期：2019-03-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell non-Hodgkin lymphoma with 2 main clinical presentations: primary cutaneous ALCL (pcALCL) and systemic ALCL (sALCL). While rare cases of myxoid sALCL have been reported, there are no previous cases of myxoid pcALCL reported. We present 2 unusual cases of pcALCL sh...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Eginli A,Cassarino DS

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Melanocytic nevi from the genitalia are uncommon. Nevi on the vulva are much better described than nevi on male genitalia. To our knowledge, a systematic study of preputial melanocytic nevi has not been reported. OBJECTIVE:To investigate the frequency of clinically unapparent melanocytic nevi on a series of...

journal_title：Journal of cutaneous pathology

authors： Val-Bernal JF,Val D,Garijo MF

更新日期：2009-04-01 00:00:00

abstract：:The number of epithelial cells per unit volume of tissue (NV) and the relative volume (VV) occupied by the spinous and basal layers of X-irradiated and non-irradiated rat-tail epidermis were studied using techniques of stereologic cytology. By a simple calculation, the absolute volumes of basal and spinous keratinocyt...

journal_title：Journal of cutaneous pathology

authors： Klein-Szanto AJ,De Rey BM,Cabrini RL

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neoplasm, which is often associated with Merkel cell polyomavirus (MCPyV). Programmed death-1 (PD-1) and its ligand PD-L1 are key players of the tumor microenvironment (TME). METHODS:Fourteen paraffin-embedded tissue samples of MCC were stratified by their MCPyV ...

journal_title：Journal of cutaneous pathology

authors： Mitteldorf C,Berisha A,Tronnier M,Pfaltz MC,Kempf W

更新日期：2017-09-01 00:00:00

abstract：:Immunohistochemical properties were studied in 16 lesions from 11 patients with chordoma involving the skin. There were nine men and two women ranging from 21 to 62 years old (mean, 42.6). The initial tumor was sacrococcygeal in 10 cases and nasopharyngeal in 1 case. Three lesions represented a direct extension from t...

journal_title：Journal of cutaneous pathology

authors： Gagné EJ,Su WP

更新日期：1992-12-01 00:00:00

abstract：:Eccrine nevi are rare hamartomas characterized by an increase in the number or size of eccrine glands. A polypoid form located in the coccygeal area has been described in a few cases and termed coccygeal polypoid eccrine nevus (CPEN). No association with internal malformations was reported in any of these cases. We de...

journal_title：Journal of cutaneous pathology

authors： Frouin E,Riviere B,Maillet O,Willems M,Kalfa N,Costes V,Bessis D

更新日期：2016-08-01 00:00:00

abstract：:Dermal non-neural granular cell tumor (NNGCT) was first described in 1991 as an S100-negative polypoid non-melanocytic tumor. Although originally introduced in the literature as a primary cutaneous tumor, it was later emphasized that such qualification could not be held until the line of differentiation was clarified....

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Cassarino DS,Riveiro-Falkenbach E,Rodriguez-Peralto JL,Fernandez-Figueras MT,Monteagudo C

更新日期：2017-06-01 00:00:00

abstract：:Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphological...

journal_title：Journal of cutaneous pathology

authors： Johnson G,Gardner JM,Shalin SC

更新日期：2017-08-01 00:00:00

abstract：:The plasma membrane ultrastructure of the extramammary Paget cells was characterized by freeze-fracture electron microscopy, which was first employed for the study of Paget cells. The Paget cell plasma membrane revealed a flat fractured plane with much fewer and smaller desmosome-particle aggregations than those of th...

journal_title：Journal of cutaneous pathology

authors： Kitajima Y,Mori S

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Morphea (localized scleroderma) and eosinophilic fasciitis (EF) are rare fibrosing disorders which may present a diagnostic challenge. While histopathologic features are often distinct, in some cases there may be overlap. T-cells contribute to etiopathogenesis of both autoimmune conditions. We sought to dete...

journal_title：Journal of cutaneous pathology

authors： Moy AP,Maryamchik E,Nikolskaia OV,Nazarian RM

更新日期：2017-06-01 00:00:00

abstract：:Keratoacanthoma (KA), an epithelial neoplasm occurring in sun-exposed skin of the elderly, is considered a well-differentiated form of conventional squamous cell carcinoma (SCC) that often follows a course of spontaneous regression. Distinguishing KA from conventional SCC or pseudocarcinomatous epithelial hyperplasia ...

journal_title：Journal of cutaneous pathology

authors： Shah K,Kazlouskaya V,Lal K,Molina D,Elston DM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The diagnosis of tuberculoid leprosy is often difficult on hematoxylin and eosin (H&E) due to the absence of demonstrable nerve destruction. This study evaluates the utility of S-100 staining in identifying nerve fragmentation and differentiation of tuberculoid leprosy from other cutaneous granulomatous dise...

journal_title：Journal of cutaneous pathology

authors： Gupta SK,Nigam S,Mandal AK,Kumar V

更新日期：2006-07-01 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) are important keratinocyte mitogens. Their effects are mediated by a cell membrane receptor (EGFR), quantitative and qualitative abnormalities of which may be responsible for deranged keratinocyte proliferation and differentiation. We have ...

journal_title：Journal of cutaneous pathology

authors： Groves RW,Allen MH,MacDonald DM

更新日期：1992-02-01 00:00:00

abstract：:Light and electron-microscopic studies were performed on the amelanotic and adjacent normal-appearing skin in patients with vitiligo. The amelanotic skin revealed complete loss of pigment and absence of melanocytes. In addition to severe degenerative changes of melanocytes, varying degree of damage was also seen in th...

journal_title：Journal of cutaneous pathology

authors： Bhawan J,Bhutani LK

更新日期：1983-06-01 00:00:00

abstract：AIM:Adnexal tumors with divergent lines of differentiation are uncommon. Herein, I report a hamartoma of the eyelid with follicular, sebaceous and apocrine differentiation that exhibited prominent melanin pigmentation. METHODS:A 63-year-old white woman had a nodule present on her left upper eyelid for 15 years. The no...

journal_title：Journal of cutaneous pathology

authors： Proia AD

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:To date, there has been no systematic investigation of the detailed histological features of prurigo nodularis (PN) in a large cohort of patients. METHODS:This retrospective study includes skin biopsies of 136 patients (63 males, 73 females; mean age: 58.38 years) with PN. RESULTS:Highly characteristic for...

journal_title：Journal of cutaneous pathology

authors： Weigelt N,Metze D,Ständer S

更新日期：2010-05-01 00:00:00

abstract：:Penicillamine-induced cutaneous elastosis perforans serpiginosa associated with a large air-cyst in the right lung is described in a 29-year-old female patient with Wilson disease. Identical light and electron-microscopic changes were present in both dermal and pulmonary elastic tissue, suggesting a disseminated drug-...

journal_title：Journal of cutaneous pathology

authors： Bardach H,Gebhart W,Niebauer G

更新日期：1979-08-01 00:00:00

abstract：:The term "nevoid malignant melanoma" (nevoid MM) is used here to describe rare nodular malignant melanomas that may escape detection in routine histological sections due to the lack of a prominent intraepidermal component, sharp lateral circumscription and evidence of partial maturation with descent in the dermis. Nev...

journal_title：Journal of cutaneous pathology

authors： McNutt NS,Urmacher C,Hakimian J,Hoss DM,Lugo J

更新日期：1995-12-01 00:00:00

abstract：:We report a rare case of multiple, co-exisitng verruciform xanthomas (VXs) of the anogenital region in the setting of cutaneous trauma. VX is a rare benign mucocutaneous neoplasm that typically presents as a solitary lesion with a predilection for the oral cavity, although extra-oral lesions have been reported involvi...

journal_title：Journal of cutaneous pathology

authors： Cumberland L,Dana A,Resh B,Fitzpatrick J,Goldenberg G

更新日期：2010-08-01 00:00:00

abstract：:Factor XIIIa (FXIIIa), a blood and intracellularly produced coagulation factor, has been found in a variety of cell types including fibroblast-like mesenchymal cells, and has been shown to stimulate the proliferation of fibroblasts and some neoplastic cells in vitro. We have already shown that the dendritic fibroblast...

journal_title：Journal of cutaneous pathology

authors： Nemeth AJ,Penneys NS

更新日期：1989-10-01 00:00:00

abstract：:Traditionally, the pigmented purpuric eruptions (PPE) have been subdivided into four histologic categories, based upon variations in histologic pattern and clinical morphologies. In recent years, it has become apparent that the lesions behave similarly, and this family of eruptions has become grouped under the term PP...

journal_title：Journal of cutaneous pathology

authors： Smoller BR,Kamel OW

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Genital basal cell carcinoma (BCC) accounts for <1% of all BCCs. We aimed to elucidate the pathogenesis of genital BCC. METHODS:We retrospectively evaluated cases of pathologically diagnosed genital BCC between 1990 and 2016 in an Asian tertiary referral center. The control group was composed of consecutive...

journal_title：Journal of cutaneous pathology

authors： Wang YJ,Tang TY,Wang JY,Huang YK,Wu YH

更新日期：2018-06-19 00:00:00

abstract：:Discrete junctional cellular aggregates ("nests"), partially staining with melanocytic markers, are described in lichenoid tissue reaction, mainly from chronically sun-exposed skin. The concomitant epidermal flattening and papillary dermal fibrosis with melanophages, may raise the differential diagnosis to that of a r...

journal_title：Journal of cutaneous pathology

authors： Ferrara G,Bradamante M,Broglia I,Petrillo G,Stefanato CM

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Changes in the clinical appearance of benign dermal nevi during pregnancy may be concerning for malignant transformation. Because the hormonal milieu of pregnancy has not proven to alter their banal behavior, histologic characterization is needed to prevent over-diagnosis and unnecessary treatment. METHODS:...

journal_title：Journal of cutaneous pathology

authors： Chan MP,Chan MM,Tahan SR

更新日期：2010-08-01 00:00:00

abstract：:The nuclei of spindle and epithelioid cell nevus (SECN) cells often contain inclusions. To determine the origin and pathogenesis of the nuclear inclusions, 12 cases of SECN were electron microscopically examined. True inclusions, pseudoinclusions, and electron-lucent areas were frequently found in the nuclei of SECN c...

journal_title：Journal of cutaneous pathology

authors： Sakamoto F,Ito M,Sato Y

更新日期：1990-04-01 00:00:00

abstract：:Patients with primary immunodeficiency are at increased risk for malignancy, especially hematologic neoplasms. This paper reports a unique case of a 47-year-old man with X-linked agammaglobulinemia who presented with progressive asymptomatic violaceous papules and plaques on his face, hands, and trunk for 1 year. Skin...

journal_title：Journal of cutaneous pathology

authors： Daou H,Hatch LA,Weinkle A,Morey GE,Messina J,Zhang X,Sokol L,Seminario-Vidal L

更新日期：2020-09-03 00:00:00

abstract：:Primary cutaneous extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) represents a monoclonal B-cell neoplasm that typically presents with papules, plaques or nodules. We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenot...

journal_title：Journal of cutaneous pathology

authors： Edinger JT,Lorenzo CR,Breneman DL,Swerdlow SH

更新日期：2011-09-01 00:00:00

abstract：:We describe the case of a cutaneous symplastic leiomyoma in a 37-year-old woman who presented with a 4-year history of a painful slow growing lesion on the left upper arm. The lesion was excised and subjected to histological examination. A poorly circumscribed lesion was seen in the dermis composed of spindle shaped c...

journal_title：Journal of cutaneous pathology

authors： Usmani N,Merchant W,Yung A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The cell origin of dermatofibroma (DF) has not been clarified satisfactorily. This study was undertaken to assess the distribution of fibroblasts and the relationship between fibroblasts and other constituent cells in DF by 47-kDa heat-shock protein (HSP47), a cell marker for skin fibroblast. METHODS:Immuno...

journal_title：Journal of cutaneous pathology

authors： Kuroda K,Tajima S

更新日期：2008-01-01 00:00:00