Perforating elastic fibers ('elastic fiber trapping') in the differentiation of keratoacanthoma, conventional squamous cell carcinoma and pseudocarcinomatous epithelial hyperplasia.

abstract：:In seven patients suffering from lichen planus (LP) light- and electron-microscopic 3H-thymidine (3HT) labeling studies were performed and the following results were obtained. 1. Using the light-microscope, a large number of 3HT labeled cells can be observed in the dermal infiltrate of LP. Most of the labeled nuclei b...

journal_title：Journal of cutaneous pathology

authors： Ebner H,Jurecka W

更新日期：1977-09-01 00:00:00

abstract：:Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hy...

journal_title：Journal of cutaneous pathology

authors： Castillo SA,Pham AK,Barton DT,Lefferts JA,Yan S,Bridge JA,Linos K

更新日期：2019-03-01 00:00:00

abstract：:We describe a patient with thrombocytopenia-absent radius (TAR) syndrome, multisystemic Langerhans cell histiocytosis and multiple reticulohistiocytomas. A mutational study by massive sequencing identified the Val600Glu (V600E) BRAF mutation in the Langerhans cell histiocytosis lesions, but no molecular alterations we...

journal_title：Journal of cutaneous pathology

authors： Hipólito LN,Mendoza-Cembranos MD,Villaescusa MT,Jo-Velasco M,Requena L,Alegría-Landa V

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Pemphigoides gestationis (PG) is a blistering disorder of pregnancy caused by antibodies against basement membrane proteins. They are directed against the 180 kD bullous pemphigoid antigen (BPAg2), towards the epitopes within the NC 16A domain. There are many similarities between pemphigoid gestationis and b...

journal_title：Journal of cutaneous pathology

authors： Patton T,Plunkett RW,Beutner EH,Deng JS,Jukic DM

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells. It has been postulated to be an important factor in homing of lymphocytes to the skin because of its function ...

journal_title：Journal of cutaneous pathology

authors： Magro CM,Dyrsen ME

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Rhabdomyosarcoma is a malignant mesenchymal tumor with skeletal muscle differentiation. Primary cutaneous rhabdomyosarcoma is rare. We report a series of 11 cases of primary cutaneous rhabdomyosarcoma. METHODS:Cases diagnosed as rhabdomyosarcoma arising in the dermis/subcutis with no identified primary tumo...

journal_title：Journal of cutaneous pathology

authors： Marburger TB,Gardner JM,Prieto VG,Billings SD

更新日期：2012-11-01 00:00:00

abstract：:We report a hitherto undescribed unusual CD30+ clonal T-cell proliferation in a 46-year-old man with the lymphocytic variant of hypereosinophilic syndrome with a 17-year history of pruritus, generalized persistent papulonodular skin lesions and peripheral blood hypereosinophilia. A skin biopsy showed an eosinophil-ric...

journal_title：Journal of cutaneous pathology

authors： Kempf W,Kazakov DV,Szep Z,Vanecek T

更新日期：2015-02-01 00:00:00

abstract：:Penicillamine-induced cutaneous elastosis perforans serpiginosa associated with a large air-cyst in the right lung is described in a 29-year-old female patient with Wilson disease. Identical light and electron-microscopic changes were present in both dermal and pulmonary elastic tissue, suggesting a disseminated drug-...

journal_title：Journal of cutaneous pathology

authors： Bardach H,Gebhart W,Niebauer G

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Neurothekeoma is a benign tumor of putative peripheral nerve sheath origin. It occurs in a myxoid (classic) variant, cellular variant, and intermediate (mixed) variant. Cellular neurothekeoma (CNT) usually involves the head and neck or extremities of young patients. Histologically, CNT can be confused with m...

journal_title：Journal of cutaneous pathology

authors： Fullen DR,Lowe L,Su LD

更新日期：2003-02-01 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) shows cutaneous involvement in 2% of cases. Merkel cell carcinoma (MCC) is a rare primary cutaneous epithelial neoplasm most commonly found in sun-exposed sites in elderly male Caucasians. A 66-year-old man presented with a 2-month history of a purple painless 2 cm tumor on the scal...

journal_title：Journal of cutaneous pathology

authors： Craig PJ,Calonje JE,Harries M,Stefanato CM

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Silver dressings have been widely and successfully used to prevent cutaneous wounds, including burns, chronic ulcers, dermatitis and other cutaneous conditions, from infection. However, in a few cases, skin discolouration or argyria-like appearances have been reported. This study investigated the level of si...

journal_title：Journal of cutaneous pathology

authors： Wang XQ,Chang HE,Francis R,Olszowy H,Liu PY,Kempf M,Cuttle L,Kravchuk O,Phillips GE,Kimble RM

更新日期：2009-07-01 00:00:00

abstract：:The skin biopsy specimens from six patients with primary mixed IgM-IgG cryoglobulinemia were examined by immunofluorescence, light and electron microscopy. The biopsy taken from the involved skin of one patient with leg ulcers revealed small blood vessel occlusions by cryoglobulin aggregates. Since a similar finding w...

journal_title：Journal of cutaneous pathology

authors： Berliner S,Weinberger A,Ben-Bassat M,Idesess C,Hazaz B,David M,Pinkhas J

更新日期：1982-04-01 00:00:00

abstract：:LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral inje...

journal_title：Journal of cutaneous pathology

authors： Dolkar T,Trinidad CM,Nelson KC,Amaria RN,Nagarajan P,Torres-Cabala CA,Ivan D,Prieto VG,Tetzlaff MT,Curry JL,Aung PP

更新日期：2018-07-01 00:00:00

abstract：:We report on two patients with chronic myeloid leukemia (CML) who presented blastic transformation involving the skin, with leukemic infiltrates showing unusual morphologic and immunohistologic characteristics. Both patients were elderly men with a 36-month and a 40-month history of CML, respectively. They presented w...

journal_title：Journal of cutaneous pathology

authors： Kaddu S,Beham-Schmid C,Zenahlik P,Kerl H,Cerroni L

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:It is not clear why melanocyte disappearance occurs without fibrotic evolution in halo nevus and with fibrotic evolution in regressing melanoma. METHODS:Six halo nevi, seven regressing primary melanomas, and seven primary melanoma (PM) without regression were studied using immunohistochemistry for the pheno...

journal_title：Journal of cutaneous pathology

authors： Moretti S,Spallanzani A,Pinzi C,Prignano F,Fabbri P

更新日期：2007-04-01 00:00:00

abstract：:Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patie...

journal_title：Journal of cutaneous pathology

authors： Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF

更新日期：2020-12-01 00:00:00

abstract：AIMS:The differential diagnosis of acral keratoses is broad. Encompassing a variety of infectious, heritable and degenerative disorders, emphasis upon the clinical setting and histologic subtlety are often required to arrive at the correct diagnosis. Herein, we report on a series of adult patients who presented with ag...

journal_title：Journal of cutaneous pathology

authors： Saeed S,Sagatys E,Morgan MB

更新日期：2006-10-01 00:00:00

abstract：:Exposure to silver-containing compounds can result in reversible discoloration of the skin, presenting as an irregular brown or black macule, which can have a clinical appearance similar to melanoma. Both the clinical scenario and the histopathology are unique. Silver nitrate darkens with exposure to light, and the ar...

journal_title：Journal of cutaneous pathology

authors： Ondrasik RM,Jordan P,Sriharan A

更新日期：2020-12-01 00:00:00

abstract：:With the exception of skin cancer, prostatic adenocarcinoma represents the most common cancer among men in the United States and the second most common cause of cancer mortality. Mortality is often associated with metastatic disease, which in the case of prostatic adenocarcinoma typically involves bones and only rarel...

journal_title：Journal of cutaneous pathology

authors： Rattanasirivilai A,Kurban A,Lenzy YM,Yaar R

更新日期：2011-06-01 00:00:00

abstract：:Verruciform xanthoma (VX) is an uncommon lesion occurring primarily in the oral cavity. Cutaneous lesions are much less common and they preferentially arise on anogenital skin. They are not necessarily associated with a pre-existing inflammatory process. We report a VX in association with a long-standing lesion of dis...

journal_title：Journal of cutaneous pathology

authors： Meyers DC,Woosley JT,Reddick RL

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:BMI-1 is involved in the maintenance of stem cells and functions as an oncogene in both lymphomas and solid carcinomas, acting by downregulation of p16ink4a. We have investigated the expression profile of BMI-1 in normal and inflamed skin as well as in basal cell carcinomas (BCCs) and squamous cell carcinoma...

journal_title：Journal of cutaneous pathology

authors： Reinisch CM,Uthman A,Erovic BM,Pammer J

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Long-term preservation of immunofluorescence is important for re-examinations. We investigated whether the storage of direct immunofluorescent (DIF)-positive slides at room temperature was reliable in daily practice. METHODS:One hundred and twenty-five DIF-positive slides from the skin of 52 patients were e...

journal_title：Journal of cutaneous pathology

authors： Dikicioglu E,Meteoglu I,Okyay P,Culhaci N,Kacar F

更新日期：2003-08-01 00:00:00

abstract：:Serum amyloid P component (SAP) is present not only in all types of cutaneous amyloidosis, but also in the normal dermal elastic fibers as well as abnormal elastic fibers, such as elastotic degeneration of elastic fibers in actinic keratosis. It was previously postulated that the colloid substance in colloid milium is...

journal_title：Journal of cutaneous pathology

authors： Hashimoto K,Black M

更新日期：1985-04-01 00:00:00

abstract：:The histogenetic relationship amongst various dendritic cells of the dermis which may express markers including factor XIIIa (FXIIIa) or CD34 remains unclear. In this study we utilized a sensitive indirect immunoperoxidase staining technique to identify CD34 and FXIIIa, as well the monocyte/macrophage markers KP-1 and...

journal_title：Journal of cutaneous pathology

authors： Altman DA,Nickoloff BJ,Fivenson DP

更新日期：1993-04-01 00:00:00

abstract：:Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon, which is even rarer in the context of metastatic breast carcinoma. Different mechanisms of SR are still under debate, including immune-mediated response. We herein report a case of the SR of intralymphatic cutaneous metastases o...

journal_title：Journal of cutaneous pathology

authors： Tomasini C

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Histopathologic examination is sometimes inadequate for accurate and reproducible diagnosis of certain melanocytic neoplasms. As a result, more sophisticated and objective methods have been sought. The goal of this study was to identify a gene expression signature that reliably differentiated benign and mali...

journal_title：Journal of cutaneous pathology

authors： Clarke LE,Warf MB,Flake DD 2nd,Hartman AR,Tahan S,Shea CR,Gerami P,Messina J,Florell SR,Wenstrup RJ,Rushton K,Roundy KM,Rock C,Roa B,Kolquist KA,Gutin A,Billings S,Leachman S

更新日期：2015-04-01 00:00:00

abstract：:Verrucous hemangioma represents a rare congenital vascular proliferation that may be mistaken for angiokeratoma. Histopathological examination of a deep biopsy is necessary to confirm the diagnosis of verrucous hemangioma based on its involvement of the deep dermis and subcutaneous tissue. We present two cases of verr...

journal_title：Journal of cutaneous pathology

authors： Clairwood MQ,Bruckner AL,Dadras SS

更新日期：2011-09-01 00:00:00

abstract：:Dirofilaria repens (formerly Dirofilaria conjunctiva) is a natural parasite of the subcutaneous tissues of dogs, cats and wild carnivores in Europe, Africa and Asia. Microfilariae are transmitted to humans by various species of mosquito. An autochthonous case of subcutaneous dirofilariasis is reported in a Greek patie...

journal_title：Journal of cutaneous pathology

authors： Tzanetou K,Gasteratos S,Pantazopoulou A,Gogou C,Konidaris D,Fragia K

更新日期：2009-08-01 00:00:00

abstract：:A 57-year-old woman with cutaneous mastocytosis of 23 years duration developed a hyperpigmented abdominal plaque composed of confluent indurated papules that enlarged for a period of 1 year to 12 x 8 cm. Biopsy showed dermal infiltration by closely packed spindle-shaped mast cells, fibroblasts, collagen, and scattered...

journal_title：Journal of cutaneous pathology

authors： Wood C,Sina B,Webster CG,Kurgansky D,Drachenberg CB,Reedy EA

更新日期：1992-04-01 00:00:00

abstract：:The increased susceptibility of the skin of chronically immunosuppressed individuals to viral infections and sunlight-induced malignancies suggests specific drug-induced, dysfunction of local immune mechanisms within the sun-exposed skin of these individuals. To help understand the effect of immunosuppressive therapy ...

journal_title：Journal of cutaneous pathology

authors： Kelly G,Scheibner A,Murray E,Sheil R,Tiller D,Horvath J

更新日期：1987-08-01 00:00:00