Nestin expression in cutaneous melanomas and melanocytic nevi.

abstract：:Discrete junctional cellular aggregates ("nests"), partially staining with melanocytic markers, are described in lichenoid tissue reaction, mainly from chronically sun-exposed skin. The concomitant epidermal flattening and papillary dermal fibrosis with melanophages, may raise the differential diagnosis to that of a r...

journal_title：Journal of cutaneous pathology

authors： Ferrara G,Bradamante M,Broglia I,Petrillo G,Stefanato CM

更新日期：2020-07-01 00:00:00

abstract：:Goltz syndrome (focal dermal hypoplasia) is an X-linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of three cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic fea...

journal_title：Journal of cutaneous pathology

authors： Ko CJ,Antaya RJ,Zubek A,Craiglow B,Damsky W,Galan A,McNiff JM

更新日期：2016-05-01 00:00:00

abstract：:Formalin-fixed, paraffin-embedded biopsy specimens of 17 cases of squamous cell carcinoma of Marjolin's ulcer (SCC-MU), 6 cases of common SCC (SCC), and 5 cases of basal cell carcinoma (BCC) were stained with three monoclonal antikeratin antibodies (CAM 5.2, MAK-6, and MA-903), a monoclonal antivimentin antibody (V9),...

journal_title：Journal of cutaneous pathology

authors： Kim JM,Su WP,Kurtin PJ,Ziesmer S

更新日期：1992-08-01 00:00:00

abstract：:Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic ...

journal_title：Journal of cutaneous pathology

authors： Suh JH,Lee SK,Kim HY,Kim MS,Lee UH

更新日期：2019-03-01 00:00:00

abstract：:Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patie...

journal_title：Journal of cutaneous pathology

authors： Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Tumor-infiltrating lymphocytes (TILs) are considered to play an important role in the antitumoral immune response. The presence and percentage of CD8-positive tumor-infiltrating T cells have been shown to correlate with differentiation and prognosis in various neoplasms. The aim of this study was to determin...

journal_title：Journal of cutaneous pathology

authors： Kamarashev J,Schaerer L,Burg G,Schmid MH,Müller B,Kempf W

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Psoriasis vulgaris is a common chronic inflammatory dermatosis. Disorders in keratinocyte proliferation, differentiation, inflammation and immune dysregulation are the major factors implicated in the pathogenesis of psoriasis vulgaris. METHODS:The study was performed in skin specimens of 25 patients with ps...

journal_title：Journal of cutaneous pathology

authors： Doger FK,Dikicioglu E,Ergin F,Unal E,Sendur N,Uslu M

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:BRAF, a serine/threonine kinase, is a component of the retrovirus-associated sequence (RAS)-RAF-extracellular-regulated protein kinase (ERK)-MAP kinase signal transduction pathway mediating signals from RAS to ERK. The T1796A single point mutation in exon 15 of the BRAF gene has recently been reported in a h...

journal_title：Journal of cutaneous pathology

authors： Palmedo G,Hantschke M,Rütten A,Mentzel T,Hügel H,Flaig MJ,Yazdi AS,Sander CA,Kutzner H

更新日期：2004-03-01 00:00:00

abstract：:Pilomatrix (pilomatrical) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only 4 cases previously published. We prese...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Cassarino DS

更新日期：2018-07-01 00:00:00

abstract：:Amyloidosis cutis dyschromica represents a rare type of primary cutaneous amyloidosis with few reported cases worldwide. It is characterized by asymptomatic, generalized hyperpigmentation with intermingled hypopigmented macules without atrophy or telangiectasia. We report herein a 19-year-old female who developed this...

journal_title：Journal of cutaneous pathology

authors： Garg T,Chander R,Jabeen M,Barara M,Mittal K,Jain M,Puri V

更新日期：2011-10-01 00:00:00

abstract：:Adult-onset Still disease (AOSD) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis and hyperferritinemia. Skin findings accompany the disease in nearly 90% of the cases. Early reports described evanescent, pruritic, salm...

journal_title：Journal of cutaneous pathology

authors： Santa E,McFalls JM,Sahu J,Lee JB

更新日期：2017-06-01 00:00:00

abstract：:We have quantified perivascular mast cells in cases of urticaria pigmentosa, urticaria, and dermal hypersensitivity reactions. To facilitate reproducibility, the mast cells were counted for a precisely defined vessel unit. These vessel units were divided arbitrarily into those < or = 55 microns and > 55 microns in lar...

journal_title：Journal of cutaneous pathology

authors： Sweet WL,Smoller BR

更新日期：1996-06-01 00:00:00

abstract：:Galli-Galli disease (GGD) and Dowling-Degos disease (DDD) are inherited skin diseases with variable progressive course. They are of benign and harmless behaviour but aesthetically annoying. They are subsumed within the group of reticulate pigmented disorders of the skin to which, additionally, Kitamura's and Haber's d...

journal_title：Journal of cutaneous pathology

authors： Müller CS,Pföhler C,Tilgen W

更新日期：2009-01-01 00:00:00

abstract：:We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), a...

journal_title：Journal of cutaneous pathology

authors： Urabe A,Matsukuma A,Shimizu N,Nishimura M,Wada H,Hori Y

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:The cell origin of dermatofibroma (DF) has not been clarified satisfactorily. This study was undertaken to assess the distribution of fibroblasts and the relationship between fibroblasts and other constituent cells in DF by 47-kDa heat-shock protein (HSP47), a cell marker for skin fibroblast. METHODS:Immuno...

journal_title：Journal of cutaneous pathology

authors： Kuroda K,Tajima S

更新日期：2008-01-01 00:00:00

abstract：:Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis. A 67-year-old man presented with a rapidly growing nodule on the ear, which had appeared over a 2-week period. Sections showed an ulcerated nodule composed of pleom...

journal_title：Journal of cutaneous pathology

authors： Murali R,Palfreeman S

更新日期：2006-05-01 00:00:00

abstract：:Immunohistochemical properties were studied in 16 lesions from 11 patients with chordoma involving the skin. There were nine men and two women ranging from 21 to 62 years old (mean, 42.6). The initial tumor was sacrococcygeal in 10 cases and nasopharyngeal in 1 case. Three lesions represented a direct extension from t...

journal_title：Journal of cutaneous pathology

authors： Gagné EJ,Su WP

更新日期：1992-12-01 00:00:00

abstract：:Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only 1 previous case of a congenital lymphadenoma. ...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Nicklaus-Wollenteit I,Sathishkumar D,Diba V,Richard B,Carr R,Moss C,Nagy A,Ogboli M,Colmenero I

更新日期：2017-11-01 00:00:00

abstract：:Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woma...

journal_title：Journal of cutaneous pathology

authors： Cohen PR,Prieto VG

更新日期：2010-08-01 00:00:00

abstract：:A 60-year-old female and a 59-year-old male each presented with a solitary circumscribed patch of depressed skin of the right thenar palm and right sole, respectively. Both lesions were present for approximately 30 years without a history of trauma or other inciting incident. Histologically, the lesions showed a well-...

journal_title：Journal of cutaneous pathology

authors： Barry CI,Glusac EJ,Kashgarian M,Gwin K,McNiff JM

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Cryptococcosis and alternariosis are rare opportunistic infections often observed in immunocompromised patients. Because Cryptococcus and Alternaria are ubiquitous fungi found in soil, the presence of fungi in the dermis has to be observed on histological examination to confirm a real cutaneous, invasive, in...

journal_title：Journal of cutaneous pathology

authors： Courville P,Favennec L,Viacroze C,Barrel A,Young P,Abboud P,Thomine E,Metayer J,Nouvet G

更新日期：2002-01-01 00:00:00

abstract：:Proliferation of the eccrine sweat duct epithelium has been associated with skin tumors, especially keratoacanthomas and basal cell carcinomas. We report our observations on the extensive sweat gland changes in a patient who had idiopathic follicular mucinosis. ...

journal_title：Journal of cutaneous pathology

authors： Berger TG,Goette DK

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This...

journal_title：Journal of cutaneous pathology

authors： Im M,Kim DH,Park JS,Chung H,Lee Y,Kim CD,Seo YJ,Lee JH

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Scleroderma/morphea is characterized by expansion of the dermis with thickened collagen bundles and loss of CD34(+) dermal dendrocytes. Variable elastic fiber changes have been described, but to our knowledge, no systematic study of the elastic fiber pattern correlated with CD34 expression has been reported....

journal_title：Journal of cutaneous pathology

authors： Walters R,Pulitzer M,Kamino H

更新日期：2009-09-01 00:00:00

abstract：:The internal organization of plasma membranes was studied in seven subjects with pemphigus vulgaris and in one subject with familial pemphigus using the freeze-fracture technique. The results obtained seem to suggest that the acantholytic process is produced in a similar fashion whatever the pathogenic agent and that ...

journal_title：Journal of cutaneous pathology

authors： Caputo R,Innocenti M,Gasparini G

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a protein that plays an important role in mitochondrial and peroxisomal beta-oxidation of branched-chain fatty acid and bile acid intermediates. AMACR has been established as a valuable diagnostic marker for prostate cancer and has recently been ...

journal_title：Journal of cutaneous pathology

authors： Halsey MA,Calder KB,Mathew R,Schlauder S,Morgan MB

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation which diagnosis can be challenging. Herein we want to describe the clinicopathological spectrum of findings in five cases of EED. METHODS:We retrospectively analyzed five cases in a single institution collected over a ...

journal_title：Journal of cutaneous pathology

authors： Sardiña LA,Jour G,Piliang MP,Bergfeld WF

更新日期：2019-02-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is a well-established marker for sweat gland differentiation in adnexal neoplasms. In contrast to previous assumptions, CEA does not represent a single oncofetal antigen but comprises a family of homologous glycoproteins, i.e. the classical CEA-180, biliary glycoprotein (BGP), and non-sp...

journal_title：Journal of cutaneous pathology

authors： Metze D,Grunert F,Neumaier M,Bhardwaj R,Amann U,Wagener C,Luger TA

更新日期：1996-02-01 00:00:00

abstract：:Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nail clinic complaining of discoloration of the lunula of the left...

journal_title：Journal of cutaneous pathology

authors： Komforti M,Selim MA,Bellet JS

更新日期：2016-04-01 00:00:00

abstract：:The expression of cytokeratins in 10 cases of clear cell hidradenoma, including 3 cases of solid cystic hidradenoma, were examined using 21 kinds of monoclonal antibodies. We divided them into three histologic patterns: massive nests with a few lumina (M nests), nests with some tubular lumina (L nests), and nests in s...

journal_title：Journal of cutaneous pathology

authors： Ohnishi T,Watanabe S

更新日期：1997-01-01 00:00:00