Subungual leiomyoma in the left thumb of a 16-year-old female.


:Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nail clinic complaining of discoloration of the lunula of the left thumbnail for 2.5 months. On initial examination, a pink longitudinal band was present in the center of the nail plate, with yellow discoloration and distal onycholysis. The patient had only mild tenderness with firm palpation, and did not recall trauma of the area. A nail matrix biopsy was performed to determine the etiology of the lesion. Microscopic examination demonstrated a well-demarcated dermal-based spindle-cell fascicular proliferation. Bland cells exhibited eosinophilic cytoplasm and elongate nuclei with blunt ends and minimal cytologic atypia. Prominent nucleoli, mitoses or necrosis were not appreciated. Immunohistochemical stains for smooth muscle actin and caldesmon highlighted the cells. Contrarily, S-100, epithelial membrane antigen, p63, factor XIIIa, CD34, CD68 and p75 were all negative. Ki-67 showed a low proliferative index. The immunoprofile combined with the morphologic features were interpreted as subungual leiomyoma. Subungual leiomyoma is a very rare diagnosis. We seek to bring awareness and expedite the diagnosis in patients with this lesion.


J Cutan Pathol


Komforti M,Selim MA,Bellet JS




Has Abstract


2016-04-01 00:00:00












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    abstract:BACKGROUND:A reduction in the expression of the pan T-cell markers CD7 and CD62L supports an endogenous T-cell dyscrasia. Previously, clone availability for CD62L restricted its application to frozen tissue sections. MATERIALS AND METHODS:A nonavidin/biotin technique to examine CD3, CD62L, and CD7 in paraffin formalin...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Magro CM,Sachdeva MP,Crowson AN,Barusevicius A,Baran PN,Kovatich AJ

    更新日期:2005-01-01 00:00:00

  • Epithelioid malignant mesothelioma metastatic to the skin: A case report and review of the literature.

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    journal_title:Journal of cutaneous pathology



    authors: Ward RE,Ali SA,Kuhar M

    更新日期:2017-12-01 00:00:00

  • Trisomy 8 in myeloid leukemia cutis confirmed by fluorescence in situ hybridization analysis.

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Shvartsbeyn M,Meehan SM,Gu P,Nierodzik ML,Perle MA

    更新日期:2012-11-01 00:00:00

  • Expression of stromal cell markers in distinct compartments of human skin cancers.

    abstract:BACKGROUND:The importance of changes in the supporting tumor stroma for cancer initiation and progression is well established. The characteristics of an activated tumor stroma, however, are not completely understood. In an effort to better characterize the desmoplastic response to human skin tumors, we evaluated the ex...

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    pub_type: 杂志文章


    authors: Huber MA,Kraut N,Schweifer N,Dolznig H,Peter RU,Schubert RD,Scharffetter-Kochanek K,Pehamberger H,Garin-Chesa P

    更新日期:2006-02-01 00:00:00

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    abstract::The nuclei of spindle and epithelioid cell nevus (SECN) cells often contain inclusions. To determine the origin and pathogenesis of the nuclear inclusions, 12 cases of SECN were electron microscopically examined. True inclusions, pseudoinclusions, and electron-lucent areas were frequently found in the nuclei of SECN c...

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    pub_type: 杂志文章


    authors: Sakamoto F,Ito M,Sato Y

    更新日期:1990-04-01 00:00:00

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Olson RL,Everett MA

    更新日期:1975-01-01 00:00:00

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Lu D,Patel KA,Duvic M,Jones D

    更新日期:2002-09-01 00:00:00

  • Histomorphologic and immunophenotypic analysis of fibrofolliculomas and trichodiscomas in Birt-Hogg-Dube syndrome and sporadic disease.

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Collins GL,Somach S,Morgan MB

    更新日期:2002-10-01 00:00:00

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Mehregan DA,Su WP,Kurtin PJ

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    authors: Fernandez-Flores A,Cassarino DS

    更新日期:2018-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Kiyohara T,Kumakiri M,Kobayashl H,Itoh K,Lao LM,Ohkawara A,Nakmura H

    更新日期:2002-02-01 00:00:00

  • Immunohistochemistry for CD117 (KIT) is effective in distinguishing cutaneous adnexal tumors with apocrine/eccrine or sebaceous differentiation from other epithelial tumors of the skin.

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    pub_type: 杂志文章


    authors: Goto K

    更新日期:2015-07-01 00:00:00

  • Angiosarcomatous transdifferentiation of metastatic melanoma.

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    authors: Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF

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    pub_type: 杂志文章


    authors: Tomasini C,Kempf W,Novelli M,Fava P,Annessi G,Rongioletti F,Fierro MT,Quaglino P

    更新日期:2015-03-01 00:00:00

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Wood WS,Killby VA,Stewart WD

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    pub_type: 杂志文章


    authors: Bister V,Mäkitalo L,Jeskanen L,Saarialho-Kere U

    更新日期:2007-12-01 00:00:00

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    更新日期:2020-08-01 00:00:00

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    journal_title:Journal of cutaneous pathology

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    authors: Barry CI,Glusac EJ,Kashgarian M,Gwin K,McNiff JM

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  • Immunohistochemical and electron microscopic observations of nevic corpuscle.

    abstract::Nevic corpuscle in the pigmented nevus was studied under light microscopy in comparison with Meissner corpuscle of the human sole skin in order to determine its ontogenesis. No nerve fibers within nevic corpuscle but coiled fibers in Meissner corpuscle could be demonstrated by Bodian stain. Presence of S-100 protein i...

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    pub_type: 杂志文章


    authors: Sueki H,Iwai M,Kato H,Nishida H

    更新日期:1984-04-01 00:00:00

  • A fresh morphological and functional look at dermal dendritic cells.

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: Nestle FO,Nickoloff BJ

    更新日期:1995-10-01 00:00:00

  • Mucocutaneous pigmented macule as a result of zinc deposition.

    abstract:BACKGROUND:Mucocutaneous depositions of various metals such as silver, lead, gold, arsenic, mercury, iron, and bismuth have been previously published. Heavy metal deposition typically occurs in the setting of either prolonged topical application to intact skin, topical application to eroded or ulcerated skin, as a resu...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Greenberg JE,Lynn M,Kirsner RS,Elgart GW,Hanly AJ

    更新日期:2002-11-01 00:00:00

  • Small skin blood vessel occlusions by cryoglobulin aggregates in ulcerative lesions in IgM-IgG cryoglobulinemia.

    abstract::The skin biopsy specimens from six patients with primary mixed IgM-IgG cryoglobulinemia were examined by immunofluorescence, light and electron microscopy. The biopsy taken from the involved skin of one patient with leg ulcers revealed small blood vessel occlusions by cryoglobulin aggregates. Since a similar finding w...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Berliner S,Weinberger A,Ben-Bassat M,Idesess C,Hazaz B,David M,Pinkhas J

    更新日期:1982-04-01 00:00:00

  • Neutrophilic eccrine hidradenitis associated with induction chemotherapy.

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Fitzpatrick JE,Bennion SD,Reed OM,Wilson T,Reddy VV,Golitz L

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  • Annular hemosiderotic histiocytoma.

    abstract::A 35-year-old woman was examined because of a symptomless multiple annular eruption. The lesion consisted of rings of closely set, smooth, firm papules that were brown in color. Hemosiderotic histiocytoma was diagnosed by light and electron microscopy. Ultrastructurally, the lesion consisted of fibroblastic and histio...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Saga K

    更新日期:1981-06-01 00:00:00

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Sabater Marco V

    更新日期:2012-07-01 00:00:00

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    pub_type: 临床试验,杂志文章


    authors: Kamyab K,Abdolreza M,Ghanadan A,Mortazavi H,Nikoo A,Motavalli F,Nasimi M

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  • Sudoriferous acrosyringeal acantholytic disease. A subset of Grover's disease.

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Hashimoto K,Moiin A,Chang MW,Tada J

    更新日期:1996-04-01 00:00:00

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    journal_title:Journal of cutaneous pathology



    authors: Pham AK,Carter JB,Ratcliffe NR,Fuld AD,Lansigan F,Burnside NJ,Guill MA 3rd,Zug KA,Jarvis LA,LeBlanc RE

    更新日期:2018-06-01 00:00:00

  • Identification of a Th2- and Th17-skewed immune phenotype in chronic urticaria with Th22 reduction dependent on autoimmunity and thyroid disease markers.

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Moy AP,Murali M,Nazarian RM

    更新日期:2016-04-01 00:00:00

  • Hypocellular medallion-like dermal dendrocyte hamartoma on the abdomen of a 25 year old male.

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    authors: Porubsky CF,Combs A,Buckley C,Goodman MB

    更新日期:2019-04-01 00:00:00