Abstract:
:Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nail clinic complaining of discoloration of the lunula of the left thumbnail for 2.5 months. On initial examination, a pink longitudinal band was present in the center of the nail plate, with yellow discoloration and distal onycholysis. The patient had only mild tenderness with firm palpation, and did not recall trauma of the area. A nail matrix biopsy was performed to determine the etiology of the lesion. Microscopic examination demonstrated a well-demarcated dermal-based spindle-cell fascicular proliferation. Bland cells exhibited eosinophilic cytoplasm and elongate nuclei with blunt ends and minimal cytologic atypia. Prominent nucleoli, mitoses or necrosis were not appreciated. Immunohistochemical stains for smooth muscle actin and caldesmon highlighted the cells. Contrarily, S-100, epithelial membrane antigen, p63, factor XIIIa, CD34, CD68 and p75 were all negative. Ki-67 showed a low proliferative index. The immunoprofile combined with the morphologic features were interpreted as subungual leiomyoma. Subungual leiomyoma is a very rare diagnosis. We seek to bring awareness and expedite the diagnosis in patients with this lesion.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Komforti M,Selim MA,Bellet JSdoi
10.1111/cup.12645subject
Has Abstractpub_date
2016-04-01 00:00:00pages
379-82issue
4eissn
0303-6987issn
1600-0560journal_volume
43pub_type
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
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