Abstract：
BACKGROUND:Apoptosis is important for maintenance of tissue homeostasis and often dysregulated in cutaneous neoplasms. The apoptosis inhibitor survivin is expressed in melanoma and non-melanoma skin cancers and benign keratinocytic lesions. Its expression has not been studied in melanocytic nevi. OBJECTIVE:We determined the expression pattern of survivin in benign melanocytic nevi in comparison to markers of proliferation and apoptosis. METHODS:Six cases of each of the following melanocytic nevi were retrieved from a dermatopathology archive: compound dysplastic nevus, intradermal nevus, compound nevus, neurotized intradermal nevus, and Spitz nevus. Survivin expression was evaluated by in situ hybridization. Apoptotic and proliferation indices were calculated by counting immunoreactive cells in terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling and proliferating cell nuclear antigen immunostained sections, respectively. RESULTS:All nevi, regardless of histologic type, expressed survivin. Compound melanocytic lesions expressed survivin in both epidermal and dermal compartments. The apoptotic rate was low for dysplastic, compound, and Spitz nevi, and apoptotic cells were not identified in any neurotized nevus. The proliferative index was highest for Spitz nevi, while all other nevi demonstrated rare positive cells. CONCLUSIONS:Survivin is consistently expressed in benign melanocytic lesions, while apoptotic cells are rarely identified, suggesting the dysregulation of apoptotic pathways with the accumulation of cells in these neoplasms.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Florell SR,Bowen AR,Hanks AN,Murphy KJ,Grossman Ddoi
10.1111/j.0303-6987.2005.00242.xkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
45-9issue
1eissn
0303-6987issn
1600-0560pii
CUP242journal_volume
32pub_type
杂志文章abstract：:Linear dermatoses are fascinating entities that likely reflect embryologically derived cutaneous mosaicism, even when they occur after childhood. Adult blaschkitis is a rare, relapsing inflammatory dermatitis that most often presents in middle age. It presents clinically as a pruritic eruption of linear papules, vesic...
journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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abstract：:Neutrophilic panniculitis is an infrequent entity, considered by most authors as part of the 'neutrophilic dermatosis' spectrum. Few cases have been reported to be related with granulocyte colony-stimulating factor (G-CSF); we report a case of neutrophilic panniculitis and Sweet's syndrome lesions related with pegfilg...
journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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