Abstract:
BACKGROUND:Cutaneous lymphatic malformations represent a group of heterogeneous diseases caused by developmental defects of lymphatic system. OBJECTIVE:The purpose of this study was to report the clinical, histopathological and immunohistochemical features of a distinctive lymphatic malformation. METHODS:Twelve patients with similar clinical and histopathological features were included in this study. Immunohistochemical staining of CD31, D2-40, Prox1 and Wilms tumor 1 (WT-1) were performed on all lesions. RESULTS:All cases were either congenital lesions or developed during the first 2 years of life. All presented as red to brown papules or nodules on acral sites. Histopathologically, the lesions consisted of a dermal proliferation of flat or slit-like vessels lined with a single layer of endothelial cells. Hemosiderin or extravascular red blood cells were present in all cases. The constituent vessels expressed CD31, D2-40 and Prox1 and lacked expression of WT-1. CONCLUSION:On the basis of the clinical, histopathological and immunohistochemical findings, our cases represent a unique type of lymphatic malformation that we believe is distinct from previously reported vascular proliferations. We propose the name of acral hemosideric lymphatic malformation for this entity.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Wang L,Gao T,Wang Gdoi
10.1111/cup.12143subject
Has Abstractpub_date
2013-07-01 00:00:00pages
657-60issue
7eissn
0303-6987issn
1600-0560journal_volume
40pub_type
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journal_title:Journal of cutaneous pathology
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abstract::Epidermal Langerhans cells (LC) from skin of clinically normal appearance in psoriatics were studied electron microscopically and compared with LC from the skin of healthy volunteers and from those with other dermatoses. Results show that LC from psoriatics display partly distinct cytoplasmic alterations. Moreover, ab...
journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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