The Wnt-signaling pathway is not implicated in tumorigenesis of Merkel cell carcinoma.

abstract：:An extensive congenital melanocytic nevus is described which, in its deeper portion, had striking neurofibromatous features. At the dermal subcutaneous junction, there were prominent subendothelial collections of nevus cells in large veins. Similar findings have been described in neurofibromatosis. The apparent relati...

journal_title：Journal of cutaneous pathology

authors： Santa Cruz DJ,Bashiti H

更新日期：1979-12-01 00:00:00

abstract：:Many melanocytic nevi contain areas similar to nerve sheath tumors (NST) and NSTs with melanin have been described. There are some NSTs with at least partial intraneural location, including neurofibromas, plexiform neurofibromas, granular cell tumors and the recently described, dendritic cell neurofibroma with pseudor...

journal_title：Journal of cutaneous pathology

authors： Weinreb I,Labonte S,Goli H,Chetty R,Ghazarian D

更新日期：2007-12-01 00:00:00

abstract：:Misonidazole, a hypoxic cell radiation-sensitizer, has been used in vivo to analyze its effect on normal and x-irradiated epidermis. The drug action was evaluated 3 days after being implanted subcutaneously. The response of the epidermis and especially of the basal cells to the drug alone and in combination with x-rad...

journal_title：Journal of cutaneous pathology

authors： de Rey BM,Lanfranchi HE,Klein-Szanto AJ,Itoiz ME

更新日期：1981-04-01 00:00:00

abstract：:We studied the degenerative "ancient" changes in 19 cases of benign cutaneous schwannoma (BCS). Using conventional and immunohistochemical stains, we found (a) degenerative changes in 15 of 19 BCS; (b) prominent vascular abnormalities in 11 of 15 BCS; and (c) cytologic atypia in 15 of 19 BCS, without mitotic figures. ...

journal_title：Journal of cutaneous pathology

authors： Argenyi ZB,Balogh K,Abraham AA

更新日期：1993-04-01 00:00:00

abstract：:Two patients with solitary lesions of pagetoid reticulosis are presented. A third case with disseminated lesions and similar microscopic detail is also reported. Lighg microscopic findings include an abnornal cell infiltrate confined to the epidermis and distributed diffusely in a pagetoid pattern. In ultrathin sectio...

journal_title：Journal of cutaneous pathology

authors： Wood WS,Killby VA,Stewart WD

更新日期：1979-04-01 00:00:00

abstract：:Sebaceous gland neoplasms such as adenoma, epithelioma, and carcinoma are uncommon cutaneous tumors. Although sporadic, their occurrence is clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous gl...

journal_title：Journal of cutaneous pathology

authors： Abbas O,Mahalingam M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The distinction of metastatic ovarian carcinoma from other metastatic carcinomas and primary adnexal lesions in the skin is often difficult. PAX8 is a transcription factor that plays a critical role in development of the Müllerian system and has been shown to be a useful discriminatory marker between ovarian...

journal_title：Journal of cutaneous pathology

authors： Fujiwara M,Taube J,Sharma M,McCalmont TH,Kim J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The lack of highly specific clinical and histopathological criteria has contributed to the delay in diagnosis of subungual melanoma in situ in its early stages. METHODS:Eighteen cases of subungual melanoma in situ, the largest series reported to date, were analyzed to characterize the clinical and histopath...

journal_title：Journal of cutaneous pathology

authors： Park SW,Jang KT,Lee JH,Park JH,Kwon GY,Mun GH,Lee DY,Lee JB,Park KK

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cardiac angiosarcoma is a rare tumor that has a predilection for middle-aged males and a marked predominance in the right atrium. The tumor may present abruptly with a fulminant clinical course. Initial presentation with metastatic disease is rare. Only one case has been reported of a patient who presented w...

journal_title：Journal of cutaneous pathology

authors： Val-Bernal JF,Figols J,Arce FP,Sanz-Ortiz J

更新日期：2001-05-01 00:00:00

abstract：:The authors report the occurrence of lichenoid and/or subacute lupus erythematosus-like eruptions in a group of patients receiving agents with antihistaminic properties. In 1 of the patients the eruption clinically resembled lichen planus, while in 5 patients the eruption resembled subacute cutaneous lupus erythematos...

journal_title：Journal of cutaneous pathology

authors： Crowson AN,Magro CM

更新日期：1999-02-01 00:00:00

abstract：:Langerhans' cell histiocytosis (LCH) may be associated with a wide range of neoplastic disorders. However, the combination of a LCH and a basal cell carcinoma (BCC) of the skin still represents a highly unusual condition. In this publication, we report the case of a 48-year-old woman who developed a localized LCH invo...

journal_title：Journal of cutaneous pathology

authors： Simonart T,Urbain F,Verdebout JM,Feoli F,Lespagnard L,Dargent JL

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Pigmentation is a characteristic clinical feature of basal cell carcinomas (BCCs) in Japanese patients. The pathogenesis of melanin pigment in pigmented BCCs is poorly understood. METHODS:We have combined the techniques of morphometric analysis and electron microscopy to assess accurately the morphologic as...

journal_title：Journal of cutaneous pathology

authors： Lao LM,Kumakiri M,Kiyohara T,Kuwahara H,Ueda K

更新日期：2001-01-01 00:00:00

abstract：:White sponge nevus (WSN) is an uncommon benign inherited disorder characterized by white and diffuse painless lesions in oral, esophageal, or genital mucosa. The lesions may develop at birth or later in childhood or adolescence, with careful clinical examination being sufficient for diagnosis in most cases. However, m...

journal_title：Journal of cutaneous pathology

authors： Bezerra KT,Leite TC,Roza ALOC,Araújo R,Israel MS,Canedo NHS,Agostini M,Benevenuto de Andrade BA,Romañach MJ

更新日期：2020-01-01 00:00:00

abstract：:The main histopathological features in the cutaneous lesions of Churg-Strauss syndrome (CSS) are dermal leukocytoclastic vasculitis with a variable eosinophilic infiltrate and non-vasculitic tissue eosinophilia with granuloma formation. This wide histopathological spectrum may account for the various skin manifestatio...

journal_title：Journal of cutaneous pathology

authors： Ishibashi M,Kudo S,Yamamoto K,Shimai N,Chen KR

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a protein that plays an important role in mitochondrial and peroxisomal beta-oxidation of branched-chain fatty acid and bile acid intermediates. AMACR has been established as a valuable diagnostic marker for prostate cancer and has recently been ...

journal_title：Journal of cutaneous pathology

authors： Halsey MA,Calder KB,Mathew R,Schlauder S,Morgan MB

更新日期：2010-04-01 00:00:00

abstract：:A case of an unusual benign apocrine hamartoma was studied by light microscopic, immunohistochemical, and electron microscopic methods. This tumor clinically showed a linear configuration and was located on the midline chest of a pubescent male. Microscopic studies revealed features of both a tubular apocrine adenoma ...

journal_title：Journal of cutaneous pathology

authors： Epstein BA,Argenyi ZB,Goldstein G,Whitaker D

更新日期：1990-02-01 00:00:00

abstract：:Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patie...

journal_title：Journal of cutaneous pathology

authors： Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF

更新日期：2020-12-01 00:00:00

abstract：:In the last 30 years, there has been a strong interest in vascular proliferations. Pyogenic granuloma was not only renamed lobular capillary hemangioma, but also the conceptual interpretation was also changed from an overgrowth of granulation tissue to a genuine hemangioma (or benign vascular neoplasm). We describe 19...

journal_title：Journal of cutaneous pathology

authors： Santa Cruz D,Plaza JA,Wick MR,Gru AA

更新日期：2021-02-01 00:00:00

abstract：:A histologically unique condition of the sweat duct was found in a miliaria-like papular eruption on the extensor surfaces of extremities of a 41-year-old female patient. The hypertrophic epithelium of the sweat duct wall consisted of extensively vacuolated clear cells. There was mild hyperkeratosis around the sweat d...

journal_title：Journal of cutaneous pathology

authors： Izaki S,Kono E,Hirai A,Kitamura K

更新日期：1994-06-01 00:00:00

abstract：:The histogenetic relationship amongst various dendritic cells of the dermis which may express markers including factor XIIIa (FXIIIa) or CD34 remains unclear. In this study we utilized a sensitive indirect immunoperoxidase staining technique to identify CD34 and FXIIIa, as well the monocyte/macrophage markers KP-1 and...

journal_title：Journal of cutaneous pathology

authors： Altman DA,Nickoloff BJ,Fivenson DP

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:To date, there has been no systematic investigation of the detailed histological features of prurigo nodularis (PN) in a large cohort of patients. METHODS:This retrospective study includes skin biopsies of 136 patients (63 males, 73 females; mean age: 58.38 years) with PN. RESULTS:Highly characteristic for...

journal_title：Journal of cutaneous pathology

authors： Weigelt N,Metze D,Ständer S

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Co-lesional acquired immunodeficiency syndrome-associated cutaneous Kaposi sarcoma (AIDS-KS) and Mycobacterium tuberculosis-associated granulomatous inflammation are undocumented. METHOD:Retrospective appraisal of skin biopsies with co-lesional AIDS-KS and microscopic tuberculosis (TB). RESULTS:Sixteen bio...

journal_title：Journal of cutaneous pathology

authors： Ramdial PK,Sing Y,Subrayan S,Calonje E,Aboobaker J,Sydney C,Sookdeo D,Ramburan A,Madiba TE

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Nerve growth factor (NGF) and its high-affinity receptor, tyrosine kinase A (TrkA), are members of the neurotrophin family. NGF-TrkA are involved in murine hair morphogenesis and cycling. To date, their expression in human hair follicle (HF) is unknown. In this investigation, we hypothesize that NGF-TrkA pro...

journal_title：Journal of cutaneous pathology

authors： Adly MA,Assaf HA,Nada EA,Soliman M,Hussein M

更新日期：2006-08-01 00:00:00

abstract：:A 59-year-old female with a cystic fibroepithelioma of Pinkus is presented. The clinical and histopathological features of this unusual variant of basal cell carcinoma are discussed. ...

journal_title：Journal of cutaneous pathology

authors： Jones CC,Ansari SJ,Tschen JA

更新日期：1991-06-01 00:00:00

abstract：:Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic ...

journal_title：Journal of cutaneous pathology

authors： Suh JH,Lee SK,Kim HY,Kim MS,Lee UH

更新日期：2019-03-01 00:00:00

abstract：:Lymphomatoid granulomatosis (LG) is a rare Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorder presenting in middle adulthood that nearly always affects the lungs and shows cutaneous involvement in up to 50% of cases. Skin lesions are present at the time of diagnosis in roughly one-third of patient...

journal_title：Journal of cutaneous pathology

authors： Rysgaard CD,Stone MS

更新日期：2015-03-01 00:00:00

abstract：:The development of cancer involves epithelial-stromal interactions. Alterations in the synthesis and deposition of type I and III collagens are related to the tumor morphology. Skin carcinogenesis in experimental animals provides a reliable model for the development of neoplasia. Ultraviolet (UV) irradiation is the ma...

journal_title：Journal of cutaneous pathology

authors： Stenbäck F,Mäkinen MJ,Jussila T,Kauppila S,Risteli J,Talve L,Risteli L

更新日期：1999-08-01 00:00:00

abstract：:Cutaneous immune-related adverse events (irAEs) are a known consequence of immune checkpoint inhibitor (ICI) therapy and may exhibit a spectrum of morphologic features both clinically and histologically. Lichenoid dermatitis associated with ICI therapy (LD-ICI) is the most frequently encountered histopathologic type o...

journal_title：Journal of cutaneous pathology

authors： Tetzlaff MT,Tang S,Duke T,Grabell DA,Cabanillas ME,Zuo Z,Yao JC,Nagarajan P,Aung PP,Torres-Cabala CA,Duvic M,Prieto VG,Huen A,Curry JL

更新日期：2019-11-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a growth factor and an angiogenesis factor which may play a role in the evolution of cutaneous malignant melanoma (CMM). In this study, we evaluated the distribution of bFGF in CMM using immunochemical methods and correlated the pattern of bFGF expression with the clinical cour...

journal_title：Journal of cutaneous pathology

authors： al-Alousi S,Barnhill R,Blessing K,Barksdale S

更新日期：1996-12-01 00:00:00

abstract：:Two elderly patients with unusual hair-follicle tumors of the face are reported. The lesions showed some histologic resemblance to pilomatrixomas but differed by the presence at the advancing edge of cytologically-atypical cells without the usual shadow cell transformation and maturation of pilomatrixomas. The term ma...

journal_title：Journal of cutaneous pathology

authors： Weedon D,Bell J,Mayze J

更新日期：1980-02-01 00:00:00