Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapy.

Abstract:

:The authors report the occurrence of lichenoid and/or subacute lupus erythematosus-like eruptions in a group of patients receiving agents with antihistaminic properties. In 1 of the patients the eruption clinically resembled lichen planus, while in 5 patients the eruption resembled subacute cutaneous lupus erythematosus (SCLE). At a light microscopic level all cases showed a lichenoid dermatitis and in 4 cases the lesions were interpreted as representing subacute lupus-like eruptions by virtue of the presence of alternating cell poor and lichenoid interface dermatitis, suprabasilar lymphocytosis around degenerating keratinocytes, and dermal mucinosis. Despite the resemblance at a clinical and light microscopic level to SCLE, anti-Ro seropositivity could not be established in any of the cases. One case, however, did demonstrate antihistone antibodies in concert with a high antinuclear antibody titer. A causal association was implicated by virtue of lesional resolution following drug withdrawal. The association of cutaneous eruptions resembling SCLE with antihistamine intake is seemingly a novel one. The possible pathogenetic basis of the eruptions is discussed.

journal_name

J Cutan Pathol

authors

Crowson AN,Magro CM

doi

10.1111/j.1600-0560.1999.tb01809.x

keywords:

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

95-9

issue

2

eissn

0303-6987

issn

1600-0560

journal_volume

26

pub_type

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