PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases.

Abstract:

BACKGROUND:The distinction of metastatic ovarian carcinoma from other metastatic carcinomas and primary adnexal lesions in the skin is often difficult. PAX8 is a transcription factor that plays a critical role in development of the Müllerian system and has been shown to be a useful discriminatory marker between ovarian and breast carcinomas. Identification of ovarian cutaneous metastases may be of benefit in patients with familial breast-ovarian carcinoma syndrome. METHODS:PAX8 immunohistochemical analysis was performed on 24 cases of metastatic adenocarcinomas to the skin and compared with 7 cases of primary adnexal lesions and also compared with p63 immunohistochemical staining results. Patients with metastatic adenocarcinomas had clinically documented primary malignancies, and patients with primary adnexal carcinomas had no known history of another adenocarcinoma. RESULTS:Cutaneous ovarian and renal cell carcinoma metastases (2/2 and 8/8, respectively) showed positive nuclear expression of PAX8. PAX8 immunohistochemical staining in primary adnexal and other cutaneous metastases was completely negative (0/7 and 0/16, respectively). The p63 expression profile supported the distinction between adnexal and metastatic adenocarcinomas. CONCLUSIONS:Although cutaneous ovarian metastasis is a rare phenomenon, the prognosis is extremely poor. PAX8 expression is a useful marker that effectively discriminated metastatic ovarian carcinomas from metastatic breast carcinomas and primary adnexal tumors.

journal_name

J Cutan Pathol

authors

Fujiwara M,Taube J,Sharma M,McCalmont TH,Kim J

doi

10.1111/j.1600-0560.2010.01564.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

938-43

issue

9

eissn

0303-6987

issn

1600-0560

pii

CUP1564

journal_volume

37

pub_type

杂志文章
  • Herpetic syringitis associated with eccrine squamous syringometaplasia in HIV-positive patients.

    abstract::Herpetic syringitis has been described as a rare manifestation of herpes virus infection in patients with an immunodeficiency, usually secondary to human immunodeficiency virus (HIV) infection. Eccrine squamous syringometaplasia (ESS) is an infrequent alteration of the eccrine duct epithelium reported in association w...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1997.tb00817.x

    authors: Muñoz E,Valks R,Fernández-Herrera J,Fraga J

    更新日期:1997-08-01 00:00:00

  • A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath melanoma).

    abstract::Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hy...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13400

    authors: Castillo SA,Pham AK,Barton DT,Lefferts JA,Yan S,Bridge JA,Linos K

    更新日期:2019-03-01 00:00:00

  • Mucocutaneous pigmented macule as a result of zinc deposition.

    abstract:BACKGROUND:Mucocutaneous depositions of various metals such as silver, lead, gold, arsenic, mercury, iron, and bismuth have been previously published. Heavy metal deposition typically occurs in the setting of either prolonged topical application to intact skin, topical application to eroded or ulcerated skin, as a resu...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0560.2002.291008.x

    authors: Greenberg JE,Lynn M,Kirsner RS,Elgart GW,Hanly AJ

    更新日期:2002-11-01 00:00:00

  • Basal cell carcinoma with monster cells.

    abstract::A case of basal cell carcinoma with "monster cells" is reported. Clinically, the lesion presented as a red nodule on the forearm of a 58-year-old male. The histologic picture was striking, with large, "monstrous" nuclei scattered throughout a well defined nodule. Basal cell carcinoma with monster cells appears to repr...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1993.tb01253.x

    authors: Elston DM,Bergfeld WF,Petroff N

    更新日期:1993-02-01 00:00:00

  • CD44 and hyaluronate expression in follicular mucinosis.

    abstract:BACKGROUND:CD44 is a membrane glycoprotein and the major cell-surface receptor of hyaluronate (HA). Lack of CD44 expression in mouse epidermis leads to an abnormal HA accumulation in the dermis, indicating an important role of CD44 in local HA metabolism. Decrease of epidermal CD44 expression in patients of lichen scle...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2006.00463.x

    authors: Kaya G,Augsburger E,Chavaz P,Saurat JH

    更新日期:2006-03-01 00:00:00

  • Acral keratosis with eosinophilic dermal deposits: a distinctive clinicopatholgic entity or colloid milium redux?

    abstract:AIMS:The differential diagnosis of acral keratoses is broad. Encompassing a variety of infectious, heritable and degenerative disorders, emphasis upon the clinical setting and histologic subtlety are often required to arrive at the correct diagnosis. Herein, we report on a series of adult patients who presented with ag...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2006.00530.x

    authors: Saeed S,Sagatys E,Morgan MB

    更新日期:2006-10-01 00:00:00

  • Proliferation of HSP47-positive skin fibroblasts in dermatofibroma.

    abstract:BACKGROUND:The cell origin of dermatofibroma (DF) has not been clarified satisfactorily. This study was undertaken to assess the distribution of fibroblasts and the relationship between fibroblasts and other constituent cells in DF by 47-kDa heat-shock protein (HSP47), a cell marker for skin fibroblast. METHODS:Immuno...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2007.00768.x

    authors: Kuroda K,Tajima S

    更新日期:2008-01-01 00:00:00

  • Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: could it be related to a different cytokine microenvironment?

    abstract:BACKGROUND:It is not clear why melanocyte disappearance occurs without fibrotic evolution in halo nevus and with fibrotic evolution in regressing melanoma. METHODS:Six halo nevi, seven regressing primary melanomas, and seven primary melanoma (PM) without regression were studied using immunohistochemistry for the pheno...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2006.00616.x

    authors: Moretti S,Spallanzani A,Pinzi C,Prignano F,Fabbri P

    更新日期:2007-04-01 00:00:00

  • Acral verruca-like presentation of chronic graft-vs.-host disease.

    abstract:BACKGROUND:Chronic graft-vs.-host disease (GVHD) is a severe and potentially fatal complication in patients after undergoing allogeneic stem cell transplant. This disease may be hard to diagnose as it has numerous cutaneous presentations. METHODS:We report four cases of patients seen at Stanford Hospital between Janua...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12640

    authors: Park JH,Lester L,Kim J,Kwong BY

    更新日期:2016-03-01 00:00:00

  • Panniculitis-an unusual cutaneous manifestation of systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. Lipomembranous panniculitis is a peculiar type of fat necrosis and has been rep...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2009.01356.x

    authors: Almeida MS,Lima SC,Carvalho LL,Almeida JV,Santos LG,Rolim JR,Rocha TE

    更新日期:2010-11-01 00:00:00

  • Role of histology in providing prognostic information in mycosis fungoides.

    abstract::Many patients who present with patch and early plaque stage mycosis fungoides follow an indolent course and survive for many years following diagnosis. A certain subset of patients, however, have rapidly progressive disease leading to accelerated demise. We examined 21 histologic sections from initial biopsies taken f...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1998.tb01751.x

    authors: Smoller BR,Detwiler SP,Kohler S,Hoppe RT,Kim YH

    更新日期:1998-07-01 00:00:00

  • Ultrastructural localization of cell junctional components (desmoglein, plakoglobin, E-cadherin, and beta-catenin) in Hailey-Hailey disease, Darier's disease, and pemphigus vulgaris.

    abstract::The distribution of desmoglein, plakoglobin, E-cadherin, and beta-catenin in the peri-lesional and lesional skin of Hailey-Hailey disease, Darier's disease, and pemphigus vulgaris was examined by immunoelectron microscopy. In the peri-lesional skin, the immunolabeling of these desmosomal components was localized to de...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1998.tb01698.x

    authors: Tada J,Hashimoto K

    更新日期:1998-02-01 00:00:00

  • Multiple infundibulocystic basal cell carcinomas in association with human immunodeficiency virus.

    abstract::Infundibulocystic basal cell carcinoma (IBCC) is a relatively recently described variant of basal cell carcinoma that is controversial and not universally accepted. Excluding cases of nevoid basal cell carcinoma syndrome, IBCC usually presents as a small, solitary, superficial lesion on the face of older persons. Ther...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0560.2000.027006316.x

    authors: Kagen MH,Hirsch RJ,Chu P,McCormack PC,Weinberg JM

    更新日期:2000-07-01 00:00:00

  • Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides.

    abstract:INTRODUCTION:Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDCs) are a subset of interferon-producing dendritic cells that link the innate and the adaptative immune...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13438

    authors: Fernandez-Flores A,Cassarino DS

    更新日期:2019-05-01 00:00:00

  • Metastatic follicular carcinoma of the thyroid to the skin: a case confirmed by immunohistochemistry.

    abstract::A 78-year-old woman with a history of follicular carcinoma of the thyroid developed a painless nodule on her face. A skin biopsy showed a dermal tumor composed of cells with granular, eosinophilic cytoplasm. Immunoperoxidase staining demonstrated thyroglobulin in the tumor cells, confirming the diagnosis of metastatic...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1985.tb01609.x

    authors: Rico MJ,Penneys NS

    更新日期:1985-04-01 00:00:00

  • Cystic fibroepithelioma of pinkus.

    abstract::A 59-year-old female with a cystic fibroepithelioma of Pinkus is presented. The clinical and histopathological features of this unusual variant of basal cell carcinoma are discussed. ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1991.tb00157.x

    authors: Jones CC,Ansari SJ,Tschen JA

    更新日期:1991-06-01 00:00:00

  • Histology of benign virus induced tumors of the skin.

    abstract::The majority of findings in relation to warts have been passed on from one textbook to the other since the end of the last century. More recent studies have been carried out with the electron microscope. But information is lacking as to histology, histochemistry, examination with the phase-contrast microscope, with th...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1978.tb00938.x

    authors: Steigleder GK

    更新日期:1978-04-01 00:00:00

  • Immunohistochemistry utilization in the diagnosis of melanoma.

    abstract:BACKGROUND:The use of immunohistochemical (IHC) stains in dermatopathology is commonplace; however, little is known regarding utilization trends in melanoma diagnosis. Current Medicare local coverage determinations (LCDs) state that most pigmented lesions, including melanoma, can be diagnosed using H&E alone. METHODS:...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.13648

    authors: Dinehart MS,Dinehart SM,Sukpraprut-Braaten S,High WA

    更新日期:2020-05-01 00:00:00

  • Epidermal programmed cell death-ligand 1 expression in TEN associated with nivolumab therapy.

    abstract::Nivolumab is a programmed cell death receptor-1 (PD-1) antibody used in the treatment of metastatic or unresectable melanoma. Cutaneous reactions are the most common adverse events reported with these agents and are rarely severe or life-threatening. Here we present a case report describing the clinicopathological fin...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.12876

    authors: Vivar KL,Deschaine M,Messina J,Divine JM,Rabionet A,Patel N,Harrington MA,Seminario-Vidal L

    更新日期:2017-04-01 00:00:00

  • Steatocystoma multiplex associated with bilateral preauricular sinuses.

    abstract::Steatocystoma multiplex is characterized by the development of numerous steatocystomas. The condition has occasionally been related to congenital bilateral preauricular sinuses. Herein, we present the third case of such an association, a 34-year-old male who was born with bilateral preauricular sinuses that were surgi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12315

    authors: Fernandez-Flores A,Cuesta CC,García CS,del Río JS

    更新日期:2014-08-01 00:00:00

  • Interface dermatitis along Blaschko's lines.

    abstract::Linear dermatoses are fascinating entities that likely reflect embryologically derived cutaneous mosaicism, even when they occur after childhood. Adult blaschkitis is a rare, relapsing inflammatory dermatitis that most often presents in middle age. It presents clinically as a pruritic eruption of linear papules, vesic...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/cup.12412

    authors: Johnson M,Walker D,Galloway W,Gardner JM,Shalin SC

    更新日期:2014-12-01 00:00:00

  • The Wnt-signaling pathway is not implicated in tumorigenesis of Merkel cell carcinoma.

    abstract:BACKGROUND:The Wnt-signaling pathway, involving beta-catenin, apc, and axin, plays a critical role in numerous developmental events. Alterations in the Wnt-signaling pathway have been detected in a wide variety of neoplasms. However, similar aberrations have not been described in Merkel cell carcinoma (MCC). The aim of...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2006.00577.x

    authors: Liu S,Daa T,Kashima K,Kondoh Y,Yokoyama S

    更新日期:2007-01-01 00:00:00

  • Cutaneous extranodal NK/T-cell lymphoma mimicking cellulitis an HIV positive patient without lymphopenia.

    abstract::We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angioc...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.12885

    authors: Malviya N,Rainwater YB,Vandergriff T,Mauskar MM

    更新日期:2017-03-01 00:00:00

  • The application of a monoclonal antibody to CD62L on paraffin-embedded tissue samples in the assessment of the cutaneous T-cell infiltrates.

    abstract:BACKGROUND:A reduction in the expression of the pan T-cell markers CD7 and CD62L supports an endogenous T-cell dyscrasia. Previously, clone availability for CD62L restricted its application to frozen tissue sections. MATERIALS AND METHODS:A nonavidin/biotin technique to examine CD3, CD62L, and CD7 in paraffin formalin...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2005.00259.x

    authors: Magro CM,Sachdeva MP,Crowson AN,Barusevicius A,Baran PN,Kovatich AJ

    更新日期:2005-01-01 00:00:00

  • Pleural mesothelioma with cutaneous extension to chest wall scars.

    abstract:BACKGROUND:Cutaneous mesothelioma is rare but may occur following local surgical procedures for visceral mesothelioma or as a metastasis. METHODS:A patient with pleural mesothelioma, who developed papules within chest wall scars, 14 and 15 months after pleural biopsy and thoracentesis, respectively, is reported. RESU...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.0303-6987.2004.00219.x

    authors: Shieh S,Grassi M,Schwarz JK,Cheney RT

    更新日期:2004-08-01 00:00:00

  • Cutaneous histopathological findings of Aicardi-Goutières syndrome, overlap with chilblain lupus.

    abstract::We report a 2-year-old girl with developmental delay who, from the age of 1 year, developed perniotic lesions of the hands and feet initially diagnosed as chilblain lupus. Histological examination showed features of epidermal necrosis with intraepidermal bulla formation, interface dermatitis, lymphocytic vasculitis wi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2007.00900.x

    authors: Kolivras A,Aeby A,Crow YJ,Rice GI,Sass U,André J

    更新日期:2008-08-01 00:00:00

  • Cutaneous metastasis of prostatic adenocarcinoma: a cautionary tale.

    abstract::With the exception of skin cancer, prostatic adenocarcinoma represents the most common cancer among men in the United States and the second most common cause of cancer mortality. Mortality is often associated with metastatic disease, which in the case of prostatic adenocarcinoma typically involves bones and only rarel...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2011.01677.x

    authors: Rattanasirivilai A,Kurban A,Lenzy YM,Yaar R

    更新日期:2011-06-01 00:00:00

  • Verruciform xanthoma in association with discoid lupus erythematosus.

    abstract::Verruciform xanthoma (VX) is an uncommon lesion occurring primarily in the oral cavity. Cutaneous lesions are much less common and they preferentially arise on anogenital skin. They are not necessarily associated with a pre-existing inflammatory process. We report a VX in association with a long-standing lesion of dis...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.1992.tb01359.x

    authors: Meyers DC,Woosley JT,Reddick RL

    更新日期:1992-04-01 00:00:00

  • Immunohistochemistry in ocular carcinomas.

    abstract:BACKGROUND:The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging. An appropriate immunohistochemical panel may help to differentiate these lesions. METHODS:To determine the distribution and use of several immunostains...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0560.2007.00871.x

    authors: Sramek B,Lisle A,Loy T

    更新日期:2008-07-01 00:00:00

  • Unusual subcutaneous dedifferentiated liposarcoma exhibiting coexistence of meningothelial-like whorls and inflammatory myofibroblastic tumor-like structures.

    abstract::To explore the clinicopathological features of a rare dedifferentiated liposarcoma (DDLPS) with meningothelial-like whorls, we retrospectively analyzed 46 reported cases and 1 case that we encountered. Fluorescence in situ hybridization (FISH) analysis of the MDM2 amplification status of our case was also performed. O...

    journal_title:Journal of cutaneous pathology

    pub_type:

    doi:10.1111/cup.13621

    authors: Chen S,He S,Huang H,Li L,Wang W,Cui Z,Zhang R

    更新日期:2020-02-01 00:00:00