Pleural mesothelioma with cutaneous extension to chest wall scars.

Abstract:

BACKGROUND:Cutaneous mesothelioma is rare but may occur following local surgical procedures for visceral mesothelioma or as a metastasis. METHODS:A patient with pleural mesothelioma, who developed papules within chest wall scars, 14 and 15 months after pleural biopsy and thoracentesis, respectively, is reported. RESULTS:Histopathology showed an epithelioid tumor forming tubulopapillary and glandular structures. The diagnosis of mesothelioma was confirmed with immunohistochemistry. Tumor cells stained characteristically for low-molecular-weight cytokeratins 5/6, calretinin, and vimentin and were negative for mucicarmine, carcinoembryonic antigen, thyroid transcription factor 1, prostate-specific antigen, gross cystic disease fluid protein, S-100, factor VIII, and CD31. CONCLUSIONS:Histologically, mesothelioma may resemble a primary adnexal neoplasm, metastatic adenocarcinoma, or angiosarcoma. Immunohistochemistry can clarify the diagnosis. Clinicians should be aware of the varied presentations of mesothelioma, as cutaneous presentations are becoming increasingly common.

journal_name

J Cutan Pathol

authors

Shieh S,Grassi M,Schwarz JK,Cheney RT

doi

10.1111/j.0303-6987.2004.00219.x

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

497-501

issue

7

eissn

0303-6987

issn

1600-0560

pii

CUP219

journal_volume

31

pub_type

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