Abstract:
:Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal malignancy with predilection for the eyelids of older adults. It must be distinguished from metastatic adenocarcinomas of extracutaneous origin and from benign adnexal proliferations on partial samples when a solid growth component and mucin production are not evident. Thus, demonstration of neuroendocrine differentiation can help to ensure a correct diagnosis. Insulinoma-associated protein 1 (INSM1) is a novel neuroendocrine marker that has recently shown greater sensitivity than synaptophysin (SYN) and chromogranin (CHR) in the diagnosis of various neuroendocrine neoplasms. We compared the performance of these three markers across 10 examples of EMPSGC. All EMPSGCs expressed INSM1. Eight of ten were also immunoreactive for SYN; however, INSM1 staining was generally more intense and stained a greater proportion of the tumor cells. CHR staining was weak and focal in most cases. INSM1 staining was present in hidrocystoma-like components of cystic EMPSGC. These findings suggest that INSM1 may be more sensitive than SYN and CHR and thus valuable for establishing a diagnosis of EMPSGC.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Parra O,Linos K,Yan S,Lilo M,LeBlanc REdoi
10.1111/cup.13831subject
Has Abstractpub_date
2021-01-01 00:00:00pages
41-46issue
1eissn
0303-6987issn
1600-0560journal_volume
48pub_type
杂志文章abstract::An extensive congenital melanocytic nevus is described which, in its deeper portion, had striking neurofibromatous features. At the dermal subcutaneous junction, there were prominent subendothelial collections of nevus cells in large veins. Similar findings have been described in neurofibromatosis. The apparent relati...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1979.tb01180.x
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun-exposed skin of older and usually immunosuppressed individuals. METHODS:Using data from NCI's SEER (Surveillance, Epidemiology, and End Results) Program from 1973 to 2006, we analyzed the demographics and ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2009.01370.x
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Direct immunofluorescence (DIF) is a valuable tool in the diagnosis of cutaneous lupus erythematosus (LE). Our goal was to characterize the most frequent immune reactants in the skin biopsies of cutaneous LE and identify the most common immunofluorescence staining patterns. METHODS:DIF results of immunoglob...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.0303-6987.2005.00337.x
更新日期:2005-05-01 00:00:00
abstract::Human hair follicles (HF) and sebaceous glands (SG) were assessed for the presence and distribution of the cytochrome P-450-aromatase (AR) and 3B-hydroxysteroid dehydrogenase (3B-HSD) enzymes. Immunohistochemical methods were used to examine both enzymes in male and female human skin specimens at various ages and diff...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1992.tb01367.x
更新日期:1992-08-01 00:00:00
abstract::We report an unusual case occurring in a 25-year-old male of a balloon cell nevus which also showed clinical and pathological features of a halo nevus. ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1986.tb01512.x
更新日期:1986-04-01 00:00:00
abstract::We reviewed the clinical, histologic, and immunofluorescence features of 20 patients with pemphigus and neoplasia and compared them with a control group of 17 patients with pemphigus without neoplasia. Patients with neoplasia were divided according to clinical, histologic, and immunofluorescence findings into those wi...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1993.tb00644.x
更新日期:1993-06-01 00:00:00
abstract::Penicillamine-induced cutaneous elastosis perforans serpiginosa associated with a large air-cyst in the right lung is described in a 29-year-old female patient with Wilson disease. Identical light and electron-microscopic changes were present in both dermal and pulmonary elastic tissue, suggesting a disseminated drug-...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1979.tb01131.x
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Melanocytic nevi from the genitalia are uncommon. Nevi on the vulva are much better described than nevi on male genitalia. To our knowledge, a systematic study of preputial melanocytic nevi has not been reported. OBJECTIVE:To investigate the frequency of clinically unapparent melanocytic nevi on a series of...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2008.01070.x
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma, but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations. METHODS:We identified three severely dysplastic nevi, one atypical intra...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.13401
更新日期:2019-03-01 00:00:00
abstract::Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woma...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2010.01524.x
更新日期:2010-08-01 00:00:00
abstract::The number of epithelial cells per unit volume of tissue (NV) and the relative volume (VV) occupied by the spinous and basal layers of X-irradiated and non-irradiated rat-tail epidermis were studied using techniques of stereologic cytology. By a simple calculation, the absolute volumes of basal and spinous keratinocyt...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1977.tb00884.x
更新日期:1977-01-01 00:00:00
abstract::Mucinous cutaneous adnexal tumors are an uncommon occurrence. We describe three cases of mucinous hidradenoma characterized by diffuse and prominent mucinous cell proliferation and discuss the relevant literature. The patients (two men and one woman) ranged in age from 32 to 72 years. The lesions were completely excis...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2006.00645.x
更新日期:2007-06-01 00:00:00
abstract::Papillary renal cell carcinoma (RCC) is an uncommon subtype of RCC that is typically encountered at early stages and has a high survival rate. Histopathology typically shows well-defined papillary architecture with tumor cells lining fibrovascular cores and can be further subdivided into type 1 and type 2 tumors based...
journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.13546
更新日期:2019-12-01 00:00:00
abstract::The lymphocytic subtypes effecting allogeneic graft-versus-host disease (GVHD) are unknown. We studied 35 skin biopsy specimens from 19 women transplanted with bone marrow from men for patterns and time course of infiltration of the skin by Y chromosome-bearing lymphocytes using in situ hybridization. Immunophenotypic...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1998.tb01721.x
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effectiveness of CD117 immunostaining for diagnosing cutaneous adnexal tumors, which has not been previously established. METHODS:CD117 immunostaining was performed on representative sections of 87 clinicopathologically confirmed cutaneous apocrine/eccrine tumors, 1...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12492
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Diagnosis of autoantibody- and immune complex-induced skin diseases is primarily based on direct immunofluorescence (DIF) microscopy. DIF staining is usually performed manually and, therefore, is labor intensive. The quality of immunohistochemical results considerably depends on the experience of the person ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12637
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Chromoblastomycosis is a chronic, suppurative, granulomatous mycosis usually confined to skin and subcutaneous tissues. The host defense mechanisms in chromoblastomycosis have not been extensively investigated. The purpose of the present study was to determine the distribution and pathways of the fungal anti...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1046/j.0303-6987.2004.0131.x
更新日期:2004-01-01 00:00:00
abstract::While some unequivocally benign infiltrates are easy to distinguish from cutaneous T-cell lymphoma (CTCL), drug-associated lymphomatoid hypersensitivity reaction and cutaneous lesions of collagen vascular disease can show cytologic atypia, clonality and an immunophenotypic profile that closely simulates CTCL and cause...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2007.00813.x
更新日期:2008-04-01 00:00:00
abstract::We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), a...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1990.tb00099.x
更新日期:1990-10-01 00:00:00
abstract::A survey of conditions with mucinous deposits is given. The most important factors for their diagnosis are to consider these disorders and to stain the slides for proteoglycans or glycosaminoglycans; the most common routine techniques are the Giemsa and the Alcian-blue stain. More sophisticated methods allow different...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1985.tb01637.x
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:The lack of highly specific clinical and histopathological criteria has contributed to the delay in diagnosis of subungual melanoma in situ in its early stages. METHODS:Eighteen cases of subungual melanoma in situ, the largest series reported to date, were analyzed to characterize the clinical and histopath...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12634
更新日期:2016-01-01 00:00:00
abstract::Acquired perforating calcific collagenosis (APCC), which is characterized by the calcification of dermal collagen fibers with subsequent transepidermal elimination and perforation, is an extremely rare entity. Thus far, it has only been reported in a patient with direct contact exposure to calcium chloride. Here, we r...
journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.13371
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Sebaceous tumors are adnexal neoplasms showing sebocytic differentiation. They range from benign to malignant and are associated with Muir-Torre syndrome (MTS). Several clinical and histopathological features associated with MTS have been described. Sebaceous tumors with an overlying cutaneous horn are extre...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12321
更新日期:2014-08-01 00:00:00
abstract::Two cases of tubular apocrine adenoma were studied by light, histochemical, and electron microscopic methods. This benign apocrine hamartoma must be considered in the classification of appendage tumors, particularly those associated with organoid epithelial nevus, and may be confused with metastatic adenocarcinoma. Th...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1976.tb00850.x
更新日期:1976-01-01 00:00:00
abstract::We describe a patient with thrombocytopenia-absent radius (TAR) syndrome, multisystemic Langerhans cell histiocytosis and multiple reticulohistiocytomas. A mutational study by massive sequencing identified the Val600Glu (V600E) BRAF mutation in the Langerhans cell histiocytosis lesions, but no molecular alterations we...
journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.13483
更新日期:2019-08-01 00:00:00
abstract::Sinonasal non-keratinizing squamous cell carcinoma (SCC), previously designated as transitional cell carcinoma or cylindrical cell carcinoma, is an uncommon malignant neoplasm with distinct histopathological features, considered to be a low-grade malignancy that usually occurs in elderly patients. Extensive local inva...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.2012.01939.x
更新日期:2012-08-01 00:00:00
abstract::The histological picture of molluscum contagiosum (MC) is well known: the epidermis grows down into the dermis as multiple, closely packed pear-shaped lobules. The epithelial cells of the outermost layers and the horny layer display typical molluscum bodies. In this paper, we describe an unusual case of MC in a cystic...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1985.tb01618.x
更新日期:1985-04-01 00:00:00
abstract::True human tails are rare vestigial structures that are typically removed in childhood. Here a case is presented in which an inconspicuous sacrococcygeal tail was incidentally discovered in late adulthood. A 56-year-old man with no significant past medical history presented to a dermatology clinic with a chief complai...
journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.12820
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Histopathologic examination is sometimes inadequate for accurate and reproducible diagnosis of certain melanocytic neoplasms. As a result, more sophisticated and objective methods have been sought. The goal of this study was to identify a gene expression signature that reliably differentiated benign and mali...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/cup.12475
更新日期:2015-04-01 00:00:00
abstract::Extraskeletal Ewing's sarcoma has been recognized as being histologically indistinguishable from Ewing's sarcoma of bone. Although the occurrence of extraosseous Ewing's sarcoma in deep soft tissues has been well described, such cutaneous lesions are rare. We report the clinical history, histopathologic findings, and ...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1985.tb00446.x
更新日期:1985-12-01 00:00:00