Abstract：
BACKGROUND:Acquired lymphedema of the genitalia is a rare childhood presentation and is more common in elderly individuals secondary to pelvic/abdomenal malignancy or its therapy or worldwide due to filariasis. OBJECTIVE:Herein, we report a case of a healthy 11-year-old boy who presented with a 1-year history of chronic, asymptomatic scrotal and penile swelling. Biopsy revealed edema, lymphangiectases and peri- and intralymphatic sarcoidal type granulomas. This histologic pattern of granulomatous lymphangitis is most commonly associated with orofacial granulomatosis (granulomatous cheilitis and Melkersson-Rosenthal syndrome) and Crohn's disease. Treatment with topical steroids and physical support has resulted in marked improvement. No systemic disease (Crohn's disease) is evident 1 year later. Literature review revealed 44 cases of genital lymphedema with non-infectious granulomas. The majority of these young patients had Crohn's disease, frequently with anal involvement and a minority, both with and without Crohn's disease, had orofacial granulomatosis. CONCLUSIONS:Granulomatous lymphangitis should be considered in the differential diagnosis of chronic idiopathic swelling of the genitalia, particularly in younger individuals. Further clinical examination, additional laboratory studies and close follow-up for co-existing or subsequent development of Crohn's disease should be performed. The overlap between granulomatous lymphangitis of the genitalia, Crohn's disease and orofacial granulomatosis suggest that granulomatous lymphangitis of the genitalia may represent a forme fruste of Crohn's disease.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Murphy MJ,Kogan B,Carlson JAdoi
10.1034/j.1600-0560.2001.028008419.xkeywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
419-24issue
8eissn
0303-6987issn
1600-0560pii
cup280806journal_volume
28pub_type
杂志文章,评审abstract：:A malignant pilomatricoma is described in a dog. The primary tumor apparently developed in the metatarsal area where there were multiple intradermal skin nodules. Lymphatic invasion by tumor cells resulted in metastasis to the mammary glands, lymph nodes and lungs. The tumor is compared to the pilomatricoma in man whe...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1981.tb01024.x
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abstract：:Folliculo-sebaceous cystic hamartoma (FCH) was described as an entity recently and was defined as an adnexal hamartoma, showing above all an infundibular cystic structure linked to many sebaceous lobules. Differentiation toward the inferior segment of the hair follicle also occurs, although to a markedly lesser degree...
journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.1998.tb01758.x
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abstract：:Imiquimod (AldaraTM), a Toll-like receptor 7 agonist (TLR7), is known for its unique properties of being an immune response modifier and stimulator. Upon topical application, this TLR7 agonist triggers a cell-mediated immune response predominantly expressed by dendritic cells and monocytes. Local skin irritation at th...
journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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abstract：BACKGROUND:Direct immunofluorescence (DIF) is a valuable tool in the diagnosis of cutaneous lupus erythematosus (LE). Our goal was to characterize the most frequent immune reactants in the skin biopsies of cutaneous LE and identify the most common immunofluorescence staining patterns. METHODS:DIF results of immunoglob...
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abstract：BACKGROUND:Among nonepithelial second neoplasms which are known to be induced by irradiation, rhabdomyosarcomas are extremely rare, and melanomas are infrequent. We report a high-grade sarcoma with rhabdomyoblastic differentiation, which appeared 30 years after megavoltage irradiation for an endometrial adenocarcinoma,...
journal_title：Journal of cutaneous pathology
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doi：10.1034/j.1600-0560.2000.027008419.x
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journal_title：Journal of cutaneous pathology
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abstract：:Lymphomatoid granulomatosis (LG) is a rare Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorder presenting in middle adulthood that nearly always affects the lungs and shows cutaneous involvement in up to 50% of cases. Skin lesions are present at the time of diagnosis in roughly one-third of patient...
journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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doi：10.1111/cup.12410
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abstract：:Although the histogenesis of sebaceous carcinomas remains unclear, the occurrence of intraepidermal or intraepithelial sebaceous carcinoma in the epidermis or conjunctiva may suggest de novo histogenesis. This report describes a case of sebaceous carcinoma within preexisting rippled/carcinoid pattern sebaceoma. This l...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12575
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1046/j.0303-6987.2004.0131.x
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Silver dressings have been widely and successfully used to prevent cutaneous wounds, including burns, chronic ulcers, dermatitis and other cutaneous conditions, from infection. However, in a few cases, skin discolouration or argyria-like appearances have been reported. This study investigated the level of si...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2008.01141.x
更新日期：2009-07-01 00:00:00
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2011.01706.x
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2007.00846.x
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abstract：:Adenomyoepithelioma is a rare, microscopically distinctive tumor of the skin. This article explores an example that presented in the inguinal area in a 29-year-old woman, mimicking adenopathy. Histopathologically, the tumor included two different areas: a cystic area consisting of tubules and glands in hyalinized stro...
journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1993.tb00233.x
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.1992.tb01599.x
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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journal_title：Journal of cutaneous pathology
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abstract：:We carried out a quantitative study of the matrix and dermal papilla of the human hair follicle of the scalp, both normal and in various degrees of androgenetic alopecia. A stereological study showed the measured parameters to decrease with increase in the degree of alopecia, particularly as regards the total volume o...
journal_title：Journal of cutaneous pathology
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doi：10.1111/j.1600-0560.1993.tb01273.x
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abstract：:Until recently the number of patients with syphilis has been diminishing. Although that trend has reversed cases of tertiary syphilis are rare and often difficult to diagnose as a substantial number of patients will have a negative rapid plasma reagin. Histologically, cutaneous lesions in late stage syphilis exist in ...
journal_title：Journal of cutaneous pathology
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doi：10.1111/cup.12770
更新日期：2016-11-01 00:00:00
