Abstract：
:The clinical, morphological and immunohistochemical features of 27 patients with anaplastic large cell lymphoma (ALCL) of CD30-positive type, with cutaneous lesions as the sole initial clinical manifestation, were analyzed. The neoplasm presented as solitary or multiple, usually ulcerated skin lesions, affecting predominantly elderly patients (median age: 67 years) with a male preponderance (male to female ratio of 6:1). In most patients, there was an excellent response to chemotherapy. The cardinal histological features included diffuse dermal and subcutaneous infiltration by large, anaplastic tumor cells, all or nearly all of which showed diffuse, strong membrane staining and frequently a paranuclear, dot-like reaction with the CD30 marker (Ber-H2). Epidermal ulceration, pseudo-epitheliomatous hyperplasia and dermal vascular proliferation were also observed.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Krishnan J,Tomaszewski MM,Kao GFdoi
10.1111/j.1600-0560.1993.tb00643.xsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
193-202issue
3eissn
0303-6987issn
1600-0560journal_volume
20pub_type
杂志文章abstract：:The diagnosis of a CD30+ cutaneous infiltrate is often difficult and requires clinicopathologic correlation. To further evaluate this challenge, initial clinical and histopathologic diagnoses were correlated with final clinicopathologic diagnosis in 44 cases with CD30 immunopositivity. Dermatopathologic evaluation con...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12510
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Recent genetic investigations support the idea that basal cell carcinoma (BCC) is trichoblastic carcinoma. However, it is generally thought that clear cell basal cell carcinoma is a result of degeneration rather than tricholemmal differentiation. METHODS:We report a case of BCC, with clear cell components, ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2003.00020.x
更新日期：2003-03-01 00:00:00
abstract：:A 60-year-old female and a 59-year-old male each presented with a solitary circumscribed patch of depressed skin of the right thenar palm and right sole, respectively. Both lesions were present for approximately 30 years without a history of trauma or other inciting incident. Histologically, the lesions showed a well-...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2007.00835.x
更新日期：2008-05-01 00:00:00
abstract：:Three selected cases of transient acantholytic dermatosis were studied because of their definitive correlation with sweating due to fever and/ or bed-ridden situations. Biopsy specimens were serially sectioned and acantholysis was found in the acrosyringium or traced to connect to the acrosyringium in all biopsy speci...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1996.tb01289.x
更新日期：1996-04-01 00:00:00
abstract：:Light and electron-microscopic studies were performed on the amelanotic and adjacent normal-appearing skin in patients with vitiligo. The amelanotic skin revealed complete loss of pigment and absence of melanocytes. In addition to severe degenerative changes of melanocytes, varying degree of damage was also seen in th...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1983.tb00328.x
更新日期：1983-06-01 00:00:00
abstract：:A case of an unusual benign apocrine hamartoma was studied by light microscopic, immunohistochemical, and electron microscopic methods. This tumor clinically showed a linear configuration and was located on the midline chest of a pubescent male. Microscopic studies revealed features of both a tubular apocrine adenoma ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1990.tb01678.x
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:Follicular mycosis fungoides is an unusual variant of mycosis fungoides (MF). Unlike classic MF where atypical lymphocytes show a predilection for the epidermis (epidermotropism), follicular MF displays a malignant lymphocytic infiltrate tropic for hair follicles (folliculotropism). This malignant lymphocyti...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1034/j.1600-0560.2001.028006318.x
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labeled as fibroblastic connective tissue nevus (FCTN). METHODS AND RESULTS:Total of 8 patients were male and 5 were female, ranging in age from 1 to 56 years. Lesions appeared ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12993
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Nestin is one of the intermediate filaments that are expressed in proliferating neural progenitor cells during development of the central nervous system (CNS) and peripheral nervous system. Postnatal re-expression of the protein occurs mainly under pathological conditions, including injury and neoplasia. In ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00627.x
更新日期：2007-05-01 00:00:00
abstract：:We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angioc...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.12885
更新日期：2017-03-01 00:00:00
abstract：:The term "outer root sheath acanthoma" is proposed to specify a distinctive keratosis exhibiting outer root sheath differentiation. This lesion features anastamosing columns of keratinocytes emanating from the undersurface of the epidermis that respectively demonstrate, with progressive descent into the upper dermis, ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1999.tb01872.x
更新日期：1999-10-01 00:00:00
abstract：:Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12435
更新日期：2015-04-01 00:00:00
abstract：:Agminated, or grouped Spitz nevi are a curious expression of nevomelanocytic growth; and represent an uncommon manifestation of these nevi. We encountered an example of agminated Spitz nevi present at birth, which showed progression and rapid growth over months. All showed histologic Spitz nevus features. Avidin-bioti...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1988.tb00537.x
更新日期：1988-06-01 00:00:00
abstract：:Confocal laser scanning microscopy (CLSM) is a new optical microscopic technique, which offers significant advantages over conventional microscopy. CLSM is microscopy of optical sections. Light, which is emitted from regions other than the focal plane, is cut off by introducing a diaphragm in the beam path. The result...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.1995.tb00747.x
更新日期：1995-06-01 00:00:00
abstract：:Accessory breast tissue is a subcutaneous remnant persisting after normal embryological development of the breast. It occurs most frequently in the axilla. Fibroadenomas in axillary breast tissue are rare. We report the case of a 29-year-old female patient who presented a fibroadenoma arising in the accessory breast t...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2012.01940.x
更新日期：2012-08-01 00:00:00
abstract：:Pilomatrix (pilomatrical) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only 4 cases previously published. We prese...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13151
更新日期：2018-07-01 00:00:00
abstract：:This study compared the fine structure of macromelanosomes with that of giant melanosome complexes formed through melanosomal autophagocytosis in nevocytes and melanocytes of nevocellular nevi, lentigo simplex and malignant melanoma. While macromelanosomes were found only on rare occasions in these pigmentary disorder...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1982.tb01069.x
更新日期：1982-10-01 00:00:00
abstract：:A histologically unique condition of the sweat duct was found in a miliaria-like papular eruption on the extensor surfaces of extremities of a 41-year-old female patient. The hypertrophic epithelium of the sweat duct wall consisted of extensively vacuolated clear cells. There was mild hyperkeratosis around the sweat d...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1994.tb00272.x
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:Psoriasis vulgaris is a common chronic inflammatory dermatosis. Disorders in keratinocyte proliferation, differentiation, inflammation and immune dysregulation are the major factors implicated in the pathogenesis of psoriasis vulgaris. METHODS:The study was performed in skin specimens of 25 patients with ps...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00719.x
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Cryptococcosis and alternariosis are rare opportunistic infections often observed in immunocompromised patients. Because Cryptococcus and Alternaria are ubiquitous fungi found in soil, the presence of fungi in the dermis has to be observed on histological examination to confirm a real cutaneous, invasive, in...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1046/j.0303-6987.2001.00035.x
更新日期：2002-01-01 00:00:00
abstract：:Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna. We report a case of Merkel cell carcinoma co-existent with sebaceous carcinoma in the right upper eyelid of a 61-year-old Japanese man. Histopathologi...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2008.01160.x
更新日期：2009-09-01 00:00:00
abstract：:Mycosis fungoides (MF) is a rare type of non-Hodgkin's lymphoma affecting the skin. Because MF develops slowly over several years and may have a variety of clinical presentations, including itchy patches, plaques or tumors that may be confused with common benign conditions such as eczema and psoriasis, the disease pre...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.2006.00662.x
更新日期：2007-07-01 00:00:00
abstract：:The plasma membrane ultrastructure of the extramammary Paget cells was characterized by freeze-fracture electron microscopy, which was first employed for the study of Paget cells. The Paget cell plasma membrane revealed a flat fractured plane with much fewer and smaller desmosome-particle aggregations than those of th...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1980.tb01210.x
更新日期：1980-12-01 00:00:00
abstract：BACKGROUND:Tumor-infiltrating lymphocytes (TILs) are considered to play an important role in the antitumoral immune response. The presence and percentage of CD8-positive tumor-infiltrating T cells have been shown to correlate with differentiation and prognosis in various neoplasms. The aim of this study was to determin...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2001.028009448.x
更新日期：2001-10-01 00:00:00
abstract：:Superficial acral fibromyxoma (SAFM) is an uncommon mesenchymal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant n...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13128
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2011.01706.x
更新日期：2011-08-01 00:00:00
abstract：:Benign fibrous histiocytoma of the skin or dermatofibroma (DF) has been regarded as a fibrohistiocytic tumor. Whether DF is a neoplastic growth or a reactive process has not been settled. Since a neoplastic process is clonal in nature, clonal analysis of DF was conducted to see if DF is a clonal disease. Fresh specime...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1034/j.1600-0560.2000.027001036.x
更新日期：2000-01-01 00:00:00
abstract：:Linear dermatoses are fascinating entities that likely reflect embryologically derived cutaneous mosaicism, even when they occur after childhood. Adult blaschkitis is a rare, relapsing inflammatory dermatitis that most often presents in middle age. It presents clinically as a pruritic eruption of linear papules, vesic...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12412
更新日期：2014-12-01 00:00:00
abstract：:Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13090
更新日期：2018-03-01 00:00:00
abstract：:Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hy...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13400
更新日期：2019-03-01 00:00:00
