Subcutaneous juvenile xanthogranuloma.


:A 1-month-old female infant was seen in consultation because of a congenital subcutaneous nodule, 2 x 3 cm in diameter, in the right retroauricular area. The nodule was surgically excised. Histologically, a large subcutaneous nodular mass was well delimited but not encapsulated. It consisted of a monomorphous sheet of foamy histiocytic cells with scattered eosinophils. Multinucleated giant cells were not found. The pure subcutaneous type of juvenile xanthogranuloma has been reported very rarely in the literature. The usual histological monomorphism of these cases, with only occasional eosinophils and lymphocytes and rare Touton giant cells, adds another diagnostic difficulty to their unusual clinical presentation.


J Cutan Pathol


Sánchez Yus E,Requena L,Villegas C,Valle P




Has Abstract


1995-10-01 00:00:00












  • An incidental finding of an asymptomatic intraneural glomus tumor: A case report and review of the literature.

    abstract::Glomus tumors are rare, soft-tissue neoplasms arising from the thermoregulatory neuromyoarterial glomus bodies. They are commonly observed in the extremities and typically present with symptoms of cold hypersensitivity, pain and localized tenderness. Intraneural glomus tumors (INGTs) are even rarer. Here we review the...

    journal_title:Journal of cutaneous pathology



    authors: Muthiah S,Hussain R,Stefanos N,Husain A

    更新日期:2018-04-01 00:00:00

  • Cutaneous mastocytosis with atypical mast cells and giant cytoplasmic granules.

    abstract::A 12-year-old male presented with an 8-year history of five firm cream colored papules on the right vertex of the scalp. A biopsy showed a dense infiltrate of monomorphous mast cells involving the dermis and extending into the subcutis. A relatively well-circumscribed cluster of larger cells showed pleomorphic nuclei ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Lachapelle J,Moroz B,Nguyen VH

    更新日期:2012-08-01 00:00:00

  • Granulomatous lymphangitis of the scrotum and penis. Report of a case and review of the literature of genital swelling with sarcoidal granulomatous inflammation.

    abstract:BACKGROUND:Acquired lymphedema of the genitalia is a rare childhood presentation and is more common in elderly individuals secondary to pelvic/abdomenal malignancy or its therapy or worldwide due to filariasis. OBJECTIVE:Herein, we report a case of a healthy 11-year-old boy who presented with a 1-year history of chron...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: Murphy MJ,Kogan B,Carlson JA

    更新日期:2001-09-01 00:00:00

  • White sponge nevus presenting as genital lesions in a 28-year-old female.

    abstract::A case is presented of white plaques occurring predominantly on the vulvar mucosa of a 28-year-old female diagnosed as white sponge nevus (WSN). WSN is a rare, autosomal dominant disorder involving mucous membranes. It predominantly affects the oral mucosa; however, it has been reported to rarely involve extraoral muc...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Cutlan JE,Saunders N,Olsen SH,Fullen DR

    更新日期:2010-03-01 00:00:00

  • PD-L1 and LAG-3 expression in advanced cutaneous squamous cell carcinomas.

    abstract:BACKGROUND:Expression of programmed death ligand 1 (PD-L1) by cutaneous squamous cell carcinomas has been shown to correlate with advanced disease and risk of metastasis. Lymphocyte activation gene 3 (LAG-3, or CD223) is an inhibitory receptor that interacts with the PD-L1 axis, which has been shown to be a marker of i...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Wu S,Slater NA,Sayed CJ,Googe PB

    更新日期:2020-10-01 00:00:00

  • Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner's lymphocytic infiltrate of the skin and cutaneous lupus erythematosus.

    abstract:BACKGROUND:Plasmacytoid dendritic cells (PDC) play a pivotal role in the induction of autoimmune diseases and other skin diseases. The present study focuses on the distribution patterns of PDC in patients with cutaneous lupus erythematosus (LE) and Jessner's lymphocytic infiltrate (LI) of the skin and compares them wit...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Tomasini D,Mentzel T,Hantschke M,Cerri A,Paredes B,Rütten A,Schärer L,Kutzner H

    更新日期:2010-11-01 00:00:00

  • A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia.

    abstract::Extramedullary hematopoiesis (EMH) in adults is a rare event, usually associated with myeloid disorders, and can be the first sign of chronic myelomonocytic leukemia. We report a case of EMH presenting as a hemorrhagic panniculitis in a patient who did not apparently present any myeloid disorders. The patient received...

    journal_title:Journal of cutaneous pathology



    authors: Gallo G,Bigliardi S,Cesinaro AM

    更新日期:2019-10-01 00:00:00

  • Cutaneous squamous cell carcinoma progression is associated with decreased GATA-3 immunohistochemical staining.

    abstract:BACKGROUND:The GATA family of transcription factors is an essential regulator of cellular proliferation and differentiation. In the skin, GATA-3 is critical for epidermal stratification and maintenance of barrier function. A role for GATA-3 in the development of human cutaneous squamous cell carcinoma (SCC) is not know...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Solus JF,Hassan K,Lee SJ,Hsi AC,Rosman IS,Dehmeri S,Schaffer A

    更新日期:2016-04-01 00:00:00

  • Sclerosing nevus with pseudomelanomatous features.

    abstract:BACKGROUND:Among the pigmented lesions with a central area of scar, we found a group of cases histologically characterized by striking architectural alteration of the melanocytic component, but with no cytological atypia and mitotically quiescent. The aim of the current study was to assess the biological nature of such...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Fabrizi G,Pennacchia I,Pagliarello C,Massi G

    更新日期:2008-11-01 00:00:00

  • Identification of a Th2- and Th17-skewed immune phenotype in chronic urticaria with Th22 reduction dependent on autoimmunity and thyroid disease markers.

    abstract:BACKGROUND:Chronic urticaria is a condition with many inciting factors and often presents a therapeutic challenge to clinicians. In addition to a central role for mast cells, an immune dysregulated state related to cytokine/chemokine alterations is increasingly being recognized. METHODS:Biopsies of chronic urticaria (...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Moy AP,Murali M,Nazarian RM

    更新日期:2016-04-01 00:00:00

  • Immunohistochemistry in ocular carcinomas.

    abstract:BACKGROUND:The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging. An appropriate immunohistochemical panel may help to differentiate these lesions. METHODS:To determine the distribution and use of several immunostains...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Sramek B,Lisle A,Loy T

    更新日期:2008-07-01 00:00:00

  • Traumatic alopecia in trichotillomania: a pathogenic interpretation of histologic lesions in the pilosebaceous unit.

    abstract::Ten patients with traumatic alopecia (trichotillomania) were being investigated histologically and, in five of them, hairs from the affected scalp area were plucked out for direct microscopic examination. Some histologic features appear to be specific markers for traumatic alopecia: empty hair ducts, plucked out hair ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Lachapelle JM,Pierard GE

    更新日期:1977-01-01 00:00:00

  • Prurigo nodularis: a reappraisal of the clinical and histologic features.

    abstract::Study of 14 patients with prurigo nodularis revealed that clinically the lesions were multiple, verrucous, and discrete and were set in normal-appearing skin. Microscopically, the lesions showed a vascular acanthomatous mass. The dermal nerves showed a tendency toward hyperplasia in parallel with the epidermal and vas...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Doyle JA,Connolly SM,Hunziker N,Winkelmann RK

    更新日期:1979-10-01 00:00:00

  • A rare case of a periorbital respiratory (choristomatous) cyst.

    abstract::Respiratory cysts are benign lesions lined by normal respiratory epithelium. There are few reported cases localized to the orbit, while those of the eyelid are exceedingly rare. Respiratory cysts usually arise either from a non-hereditary congenital malformation, where they are distinguished as choristomatous, or from...

    journal_title:Journal of cutaneous pathology



    authors: Yeh C,Atillasoy C,Seykora JT,Lee V

    更新日期:2021-01-01 00:00:00

  • A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy.

    abstract::Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Hibler J,Salavaggione AL,Martin A,Gru AA

    更新日期:2015-04-01 00:00:00

  • Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma.

    abstract:BACKGROUND:Tumors with similar or identical histopathologic features have been termed basaloid follicular hamartoma (BFH) or infundibulocystic basal cell carcinoma (BCC). BCC typically lacks immunoreactivity with cytokeratin 20 (CK20) and pleckstrin homology-like domain, family A, member 1 protein (PHLDA1). AIM:A seri...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Honarpisheh H,Glusac EJ,Ko CJ

    更新日期:2014-12-01 00:00:00

  • Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.

    abstract::The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge. The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Plaza JA,Ortega PF,Stockman DL,Suster S

    更新日期:2010-04-01 00:00:00

  • Eruptive clear cell hamartoma of sweat duct.

    abstract::A histologically unique condition of the sweat duct was found in a miliaria-like papular eruption on the extensor surfaces of extremities of a 41-year-old female patient. The hypertrophic epithelium of the sweat duct wall consisted of extensively vacuolated clear cells. There was mild hyperkeratosis around the sweat d...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Izaki S,Kono E,Hirai A,Kitamura K

    更新日期:1994-06-01 00:00:00

  • CD30+ clonal T-cell lymphoid proliferation of the skin in a patient with hypereosinophilic syndrome.

    abstract::We report a hitherto undescribed unusual CD30+ clonal T-cell proliferation in a 46-year-old man with the lymphocytic variant of hypereosinophilic syndrome with a 17-year history of pruritus, generalized persistent papulonodular skin lesions and peripheral blood hypereosinophilia. A skin biopsy showed an eosinophil-ric...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Kempf W,Kazakov DV,Szep Z,Vanecek T

    更新日期:2015-02-01 00:00:00

  • Quantitative histopathologic findings of erythromelanosis follicularis faciei et colli.

    abstract:BACKGROUND:Even though only 33 cases of Erythromelanosis follicularis faciei et colli (EFFC) have been reported around the world, there have been no quantitative clinicopathological studies yet. The purpose of this study is to examine quantitatively clinical and histopathological evaluations of EFFC using image analysi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Kim MG,Hong SJ,Son SJ,Song HJ,Kim IH,Oh CH,Moon JS

    更新日期:2001-03-01 00:00:00

  • Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal.

    abstract:BACKGROUND:Cutaneous tumor metastasis may be the first manifestation of cancer, but more often is a harbinger of advanced disease that portends an ominous prognosis. All skin accessions over the past 10 years from a large Veterans Administration (VA) hospital were reviewed. METHODS:Archived histories, glass slides, an...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Saeed S,Keehn CA,Morgan MB

    更新日期:2004-07-01 00:00:00

  • A case of multinucleate cell angiohistiocytoma in a 14-year-old boy showing two different clinical and histopathological findings.

    abstract::Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic ...

    journal_title:Journal of cutaneous pathology



    authors: Suh JH,Lee SK,Kim HY,Kim MS,Lee UH

    更新日期:2019-03-01 00:00:00

  • Circumscribed palmar hypokeratosis: two cases and a review of the literature.

    abstract::A 60-year-old female and a 59-year-old male each presented with a solitary circumscribed patch of depressed skin of the right thenar palm and right sole, respectively. Both lesions were present for approximately 30 years without a history of trauma or other inciting incident. Histologically, the lesions showed a well-...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Barry CI,Glusac EJ,Kashgarian M,Gwin K,McNiff JM

    更新日期:2008-05-01 00:00:00

  • Ofuji's disease with follicular mucinosis and its differential diagnosis from alopecia mucinosa.

    abstract:OBJECTIVES:Ofuji's disease (OD) or eosinophilic pustular folliculitis and human immunodeficiency virus-associated eosinophilic folliculitis (HIV-EF) both show eosinophil-rich folliculocentric infiltrates, and it is not clear whether they are distinguishable pathologically. Follicular mucinosis (FM) has been observed in...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Lee JY,Tsai YM,Sheu HM

    更新日期:2003-05-01 00:00:00

  • Cutaneous extraskeletal Ewing's sarcoma.

    abstract::Extraskeletal Ewing's sarcoma has been recognized as being histologically indistinguishable from Ewing's sarcoma of bone. Although the occurrence of extraosseous Ewing's sarcoma in deep soft tissues has been well described, such cutaneous lesions are rare. We report the clinical history, histopathologic findings, and ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Peters MS,Reiman HM,Muller SA

    更新日期:1985-12-01 00:00:00

  • Langerhans' cell histiocytosis arising at the site of basal cell carcinoma excision.

    abstract::Langerhans' cell histiocytosis (LCH) may be associated with a wide range of neoplastic disorders. However, the combination of a LCH and a basal cell carcinoma (BCC) of the skin still represents a highly unusual condition. In this publication, we report the case of a 48-year-old woman who developed a localized LCH invo...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Simonart T,Urbain F,Verdebout JM,Feoli F,Lespagnard L,Dargent JL

    更新日期:2000-10-01 00:00:00

  • Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.

    abstract:AIM:Adnexal tumors with divergent lines of differentiation are uncommon. Herein, I report a hamartoma of the eyelid with follicular, sebaceous and apocrine differentiation that exhibited prominent melanin pigmentation. METHODS:A 63-year-old white woman had a nodule present on her left upper eyelid for 15 years. The no...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Proia AD

    更新日期:2007-11-01 00:00:00

  • Metastatic follicular carcinoma of the thyroid to the skin: a case confirmed by immunohistochemistry.

    abstract::A 78-year-old woman with a history of follicular carcinoma of the thyroid developed a painless nodule on her face. A skin biopsy showed a dermal tumor composed of cells with granular, eosinophilic cytoplasm. Immunoperoxidase staining demonstrated thyroglobulin in the tumor cells, confirming the diagnosis of metastatic...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Rico MJ,Penneys NS

    更新日期:1985-04-01 00:00:00

  • Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development.

    abstract::Recent advances in the understanding of the metastatic phenomenon in cancer have led to the description of a metastatic niche. This concept describes a site prepared for the tumor cells in areas frequently associated with metastasis for the individual tumor studied. This niche is a "soil" that allows for the tumor cel...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Mihm MC Jr,Nelson JS

    更新日期:2010-04-01 00:00:00

  • EWSR1-PBX3 gene fusion in cutaneous syncytial myoepithelioma.

    abstract::Cutaneous syncytial myoepithelioma (CSM) is a recently recognized, histopathological variant of myoepithelial (ME) tumors of the skin. It is characterized by a syncytial arrangement of spindled, ovoid, and/or epithelioid cells forming a well-circumscribed, unencapsulated dermal nodule. There is a paucity of intervenin...

    journal_title:Journal of cutaneous pathology



    authors: MacKinnon WF,Carter MD,Bridge JA,Tremaine RD,Walsh NMG

    更新日期:2019-06-01 00:00:00