Abstract:
BACKGROUND:It is often challenging to reliably assess the number of lesional melanocytes in intraepidermal melanocytic proliferations involving sun-damaged skin. Therefore, dermatopathologists routinely use immunostains to help differentiate melanocytes from surrounding keratinocytes. METHODS:Forty-three cases of solar lentigo or melanoma in situ (of the lentigo maligna type) were retrospectively chosen (20 melanomas in situ and 23 solar lentigo). Microphthalmia transcription factor (MiTF), HMB-45, Melan-A and Mel-5 immunostains were performed with an Azure blue counterstain, and the mean melanocyte counts were calculated within a 1-mm segment of epidermis. RESULTS:In solar lentigines, the mean melanocyte counts were 27 (MiTF), 23 (HMB-45 and Mel-5) and 41 (Melan-A), as compared to hematoxylin and eosin (H&E) (25). In melanoma in situ, the mean melanocyte counts were 112 (MiTF), 149 (Melan-A), 111 (HMB-45) and 80 (Mel-5), as compared to H&E (109). CONCLUSIONS:These results show that Melan-A significantly overestimates the density of melanocytes within dermatoheliotic skin. Compared to other tested stains, nuclear staining MiTF allowed greater distinction of melanocytes from keratinocytes with melanized cytoplasm. These findings indicate that MiTF is a superior marker for quantification of melanocytes in the evaluation of subtle intraepidermal melanocytic proliferations and in the differential diagnosis of solar lentigo.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Kim J,Taube JM,McCalmont TH,Glusac EJdoi
10.1111/j.1600-0560.2011.01763.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
775-9issue
10eissn
0303-6987issn
1600-0560journal_volume
38pub_type
杂志文章abstract::We report 2 cases of congenital porokeratotic eccrine nevus in a 5-year-old girl and a 7-year-old boy. The clinical manifestations were those of nevus comedonicus palmaris. The histologic picture consisted of comedo-like dilatations and cornoid lamellae involving the eccrine ostia and ducts. One of the cases showed an...
journal_title:Journal of cutaneous pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0560.1988.tb00515.x
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abstract::Pigment-synthesizing melanoma (PSM) describes a morphologically and genetically diverse group of melanomas. In contrast, pigmented epithelioid melanocytoma (PEM) encompasses a spectrum of indolent tumors now classified as borderline/intermediate melanocytic tumors. Herein, we report a case of widely metastatic heavily...
journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0560.1998.tb01704.x
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1999.tb01849.x
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0560.1997.tb01457.x
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1987.tb01333.x
更新日期:1987-08-01 00:00:00
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
doi:10.1111/j.1600-0560.1981.tb01006.x
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abstract:BACKGROUND:During a clinical trial, we obtained 16 biopsies of skin eruptions induced by aspirin in patients with chronic idiopathic urticaria (CIU). In this setting, aspirin triggers skin eruptions through a well-established non-immunological mechanism involving the inhibition of cyclooxygenase type I. This presented ...
journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type:
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Journal of cutaneous pathology
pub_type:
doi:10.1111/cup.13026
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of cutaneous pathology
pub_type: 杂志文章
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