Production and release of peptidoglycan and wall teichoic acid polymers in pneumococci treated with beta-lactam antibiotics.

Abstract:

:Autolysin-defective pneumococci treated with inhibitory concentrations of penicillin and other beta-lactam antibiotics continued to produce non-cross-linked peptidoglycan and cell wall teichoic acid polymers, the majority of which were released into the surrounding medium. The released cell wall polymers were those synthesized by the pneumococci after the addition of the antibiotics. The peptidoglycan and wall teichoic acid chains released were not linked to one another; they could be separated by affinity chromatography on an agarose-linked phosphorylcholine-specific myeloma protein column. Omission of choline, a nutritional requirement and component of the pneumococcal teichoic acid, from the medium inhibited both teichoic acid and peptidoglycan synthesis and release. These observations are discussed in terms of plausible mechanisms for the coordination between the biosynthesis of peptidoglycan and cell wall teichoic acids.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Fischer H,Tomasz A

doi

10.1128/JB.157.2.507-513.1984

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

507-13

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

157

pub_type

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