Abstract:
:The firing patterns of single raphe units at the posterior midbrain level were examined in chloralosed rats to assess the effects of cerebellar stimulation and/or harmaline administration. Raphe cells were grouped according to their spontaneous firing rate and other characteristics into two categories. From a total sample of 160 cells, 106 (66%) presenting a slow regular discharge pattern were classified as serotonergic (5-HT cells), whereas 35 (22%), having a faster firing rate, were considered non serotonergic (NS cells). Moreover, 19 (12%) raphe units were non categorized. Cerebellar juxtafastigial (JF) stimulation modified the discharge pattern of 56 (35%) raphe units. The remaining 65% were unaffected by the stimulation. Of the 41 5-HT cells affected by JF stimulation, 28 neurons (68%) showed a systematic increase of their firing rate, whereas of the 12 NS cells affected 8 neurons (66%) were inhibited. It thus appears that cerebellar stimulation has an opposite effect on raphe units according to the cell types. Harmaline administration suppressed the activity of 5-HT cells and increased the discharge rate of NS cells. Moreover, we noticed in the latter units a phase modulation of the firing pattern by pauses occurring with a fixed periodicity of 2.5 to 10 s. Considered in the context of previous studies, these results strongly suggest an inhibitory influence of the raphe system on the olivo-cerebellar circuitry.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Weiss M,Pellet Jdoi
10.1007/BF00237211subject
Has Abstractpub_date
1982-01-01 00:00:00pages
163-70issue
2eissn
0014-4819issn
1432-1106journal_volume
48pub_type
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