Immunological response of three mouse strains to typhoid vaccine and Vi antigen.

Abstract:

:Vi-agglutinin, active cutaneous anaphylaxis and protective responses (ed(50)) of three mouse strains (CFW, NIH, and Balb/cAnN) to acetone-inactivated typhoid vaccine and soluble Vi antigen were compared. Seven days after immunization with either typhoid vaccine or Vi antigen the three strains of mice differed with respect to Vi-antibody titers. Significant differences were observed in the protective responses. Each mouse strain was significantly better protected by the intraperitoneal than by subcutaneous route of immunization. Active cutaneous anaphylaxis was more pronounced in showing strain differences in response to Vi antigen. The serological responses to Vi antigen of the strains of mice did not correlate with their protective response.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Esposito VM,Feeley JC,Leeder WD,Pittman M

doi

10.1128/JB.99.1.8-12.1969

subject

Has Abstract

pub_date

1969-07-01 00:00:00

pages

8-12

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

99

pub_type

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