Identification, characterization, and functional analysis of a gene encoding the ferric uptake regulation protein in Bartonella species.

Abstract:

:Environmental iron concentrations coordinately regulate transcription of genes involved in iron acquisition and virulence via the ferric uptake regulation (fur) system. We identified and sequenced the fur gene and flanking regions of three Bartonella species. The most notable difference between Bartonella Fur and other Fur proteins was a substantially higher predicted isoelectric point. No promoter activity or Fur autoregulation was detected using a gfp reporter gene fused to the 204 nucleotides immediately upstream of the Bartonella fur gene. Bartonella henselae fur gene expression complemented a Vibrio cholerae fur mutant.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Park SY,Kelminson KL,Lee AK,Zhang P,Warner RE,Rehkopf DH,Calderwood SB,Koehler JE

doi

10.1128/JB.183.19.5751-5755.2001

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

5751-5

issue

19

eissn

0021-9193

issn

1098-5530

journal_volume

183

pub_type

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