Abstract:
:The haemomonochorial placenta of the guinea-pig undergoes several quantitative changes between the 49th and 64th days of gestation, all of which are in such a direction as to increase the efficiency of transplacental transport. The fetal vessels become larger, the maternal vessels increase in surface area by proliferation of microvilli, and the effective mean distance between the two vessel sets decreases. The magnitude of these changes suggests that the efficiency of transport of hydrophilic solutes across the maternal-fetal interface could double, although changes in the number of permeation sites per unit area may modify this relationship. The presence of open intercellular spaces and fenestrations in the fetal endothelium suggests that this layer may not be a major permeability barrier in the guinea-pig, but may create an unstirred layer of extracellular fluid between endothelium and syncytiotrophoblast.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Firth JA,Farr Adoi
10.1007/BF00220974subject
Has Abstractpub_date
1977-11-23 00:00:00pages
507-16issue
4eissn
0302-766Xissn
1432-0878journal_volume
184pub_type
杂志文章abstract::Conventional two-dimensional cell monolayers do not provide the geometrical, biochemical and mechanical cues found in real tissues. Cells in real tissues interact through chemical and mechanical stimuli with adjacent cells and via the extracellular matrix. Such a highly interconnected communication network extends alo...
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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