Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae.

Abstract:

:Saccharomyces cerevisiae degrades allantoin in five steps to ammonia, CO(2), and glyoxylate. Previously we demonstrated that allophanic acid, the last intermediate of the pathway, was required for induction of all five degradative enzymes. The data presented here indicate that oxaluric acid, an allophanate analogue, is capable of serving as a non-metabolizable inducer. Oxaluric acid brings about a high level of induction even in strains lacking urea carboxylase. Induction observed with parabanic acid was found to result from its spontaneous breakdown to oxaluric acid.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Sumrada R,Cooper TG

doi

10.1128/JB.117.3.1240-1247.1974

subject

Has Abstract

pub_date

1974-03-01 00:00:00

pages

1240-7

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

117

pub_type

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