Adenosine 3',5'-cyclic monophosphate and morphology in Neurospora crassa: drug-induced alterations.

Abstract:

:Grown in liquid culture in the presence of a variety of structurally unrelated drugs, mycelia of wild-type Neurospora assume a colonial or semicolonial growth habit similar to that of known morphological mutants. Drugs that produce these morphological changes include atropine, theophylline, histamine, and several of the quinoline-containing antimalarials. Each of these drugs decrease the endogenous adenosine 3',5'-cyclic monophosphate (cAMP) concentration of mycelia as a result of their effect on the activity of adenyl cyclase, the cAMP-dependent phosphodiesterase, or both. The evidence indicates a relationship between the degree of morphological abnormality, the degree to which intracellular cAMP is reduced, and the action of the drugs on the adenyl cyclase and phosphodiesterase.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Scott WA,Solomon B

doi

10.1128/JB.122.2.454-463.1975

keywords:

subject

Has Abstract

pub_date

1975-05-01 00:00:00

pages

454-63

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

122

pub_type

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