Competence beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach.

Abstract:

:DNA uptake by natural competence is a central process underlying the genetic plasticity, biology, and virulence of the human respiratory opportunistic pathogen Streptococcus pneumoniae A study reported in this issue (J. Slager, R. Aprianto, and J.-W. Veening, J. Bacteriol. 201:e00780-18, https://doi.org/10.1128/JB.00780-18) combined deep-genome annotation and high-resolution transcriptome analyses to considerably extend the previous model of temporal regulation of competence at the operon and component gene levels. That extended study also provides a playbook for updating, refining, and extending genomic data sets and making them publicly available.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Winkler ME,Morrison DA

doi

10.1128/JB.00238-19

subject

Has Abstract

pub_date

2019-06-10 00:00:00

issue

13

eissn

0021-9193

issn

1098-5530

pii

JB.00238-19

journal_volume

201

pub_type

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