Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens.

Abstract:

:Attaching and effacing (AE) pathogens colonize the gut mucosa using a type three secretion system (T3SS) and a suite of effector proteins. The locus of enterocyte effacement (LEE) is the defining genetic feature of the AE pathogens, encoding the T3SS and the core effector proteins necessary for pathogenesis. Extensive research has revealed a complex regulatory network that senses and responds to a myriad of host- and microbiota-derived signals in the infected gut to control transcription of the LEE. These signals include microbiota-liberated sugars and metabolites in the gut lumen, molecular oxygen at the gut epithelium, and host hormones. Recent research has revealed that AE pathogens also recognize physical signals, such as attachment to the epithelium, and that the act of effector translocation remodels gene expression in infecting bacteria. In this review, we summarize our knowledge to date and present an integrated view of how chemical, geographical, and physical cues regulate the virulence program of AE pathogens during infection.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Furniss RCD,Clements A

doi

10.1128/JB.00336-17

subject

Has Abstract

pub_date

2017-12-20 00:00:00

issue

2

eissn

0021-9193

issn

1098-5530

pii

JB.00336-17

journal_volume

200

pub_type

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