R-factor-mediated resistance to tetracycline in Proteus mirabilis.

Abstract:

:The expression of R-factor-mediated resistance to tetracycline has been compared in Proteus mirabilis and Escherichia coli. Resistance to a range of concentrations of tetracycline was significantly lower in P. mirabilis than in E. coli in both induced and repressed states. Indirect evidence showed that conditions which result in a marked increase in the level of resistance of P. mirabilis harboring the R factor NR1 to chloramphenicol, streptomycin, and spectinomycin due to an amplification in the number of copies of r-determinants per cell do not detectably increase the level of resistance to tetracycline. Tetracycline resistance was inducible in early stationary-phase P. mirabilis NR1 although not after 5 h in this state. Double isotope labeling of control and tetracycline-induced P. mirabilis NR1 in early stationary phase revealed isotopic enrichment of certain peaks in extracts from induced cells subjected to polyacrylamide gel electrophoresis.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Franklin TJ,Rownd R

doi

10.1128/JB.115.1.235-242.1973

subject

Has Abstract

pub_date

1973-07-01 00:00:00

pages

235-42

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

115

pub_type

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