Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA.

abstract：:Iron is an essential nutrient for the survival of most organisms and has played a central role in the virulence of many infectious disease pathogens. Mycobacterial IdeR is an iron-dependent repressor that shows 80% identity in the functional domains with its corynebacterial homologue, DtxR (diphtheria toxin repressor)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manabe YC,Saviola BJ,Sun L,Murphy JR,Bishai WR

更新日期：1999-10-26 00:00:00

abstract：:Equine arteritis virus (EAV) is a positive-strand RNA virus that uses a discontinuous transcription mechanism to generate a nested set of six subgenomic mRNAs from which its structural genes are expressed. A stable bacterial plasmid (pEAV030) containing a full-length cDNA copy of the 12.7-kb EAV genome was constructed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Dinten LC,den Boon JA,Wassenaar AL,Spaan WJ,Snijder EJ

更新日期：1997-02-04 00:00:00

abstract：:Picosecond studies of rhodopsin in low-temperature glasses have been carried out in order to observe directly the risetime of prelumirhodopsin, the first intermediate in the visual pathway. Only at 20 K or below can the risetime of this intermediate be resolved and even at 4 K it is astoundingly rapid, about 36 psec. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters K,Applebury ML,Rentzepis PM

更新日期：1977-08-01 00:00:00

abstract：:mRNA-dependent cell-free protein synthesis systems were prepared from a heme-deficient ole3 mutant of the yeast Saccharomyces cerevisiae grown either in the absence or in the presence of the heme precursor delta-aminolevulinate. When supplemented with total yeast mRNA, the two systems-from heme-deficient and from heme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton B,Hofbauer R,Ruis H

更新日期：1982-12-01 00:00:00

abstract：:Rotifers of the asexual class Bdelloidea are unusual in possessing two or more divergent copies of every gene that has been examined. Phylogenetic analysis of the heat-shock gene hsp82 and the TATA-box-binding protein gene tbp in multiple bdelloid species suggested that for each gene, each copy belonged to one of two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mark Welch DB,Cummings MP,Hillis DM,Meselson M

更新日期：2004-02-10 00:00:00

abstract：:Mice prefer to mate with individuals expressing different MHC genes from their own. Volatile components presenting MHC-dependent odor types are present in urine and can be detected by mice, as shown by extensive behavioral studies. Similar odor types are suspected to influence human behavior as well. Although a recent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montag S,Frank M,Ulmer H,Wernet D,Göpel W,Rammensee HG

更新日期：2001-07-31 00:00:00

abstract：:Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman AW,Coleman JR,Griffin JD,Weltman JK,Chapman KM

更新日期：1972-03-01 00:00:00

abstract：:The thyroid hormone and retinoid X receptors form a heterodimer with each other and mediate thyroid hormone (T3)-dependent transcription. Retinoid X receptor, in addition, forms a homodimer and mediates 9-cis-retinoic acid-dependent transcription. Here, recombinant thyroid hormone receptor and recombinant retinoid X r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee IJ,Driggers PH,Medin JA,Nikodem VM,Ozato K

更新日期：1994-03-01 00:00:00

abstract：:Human T lymphocytes were shown to proliferate in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-HLA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with anti-DRw antisera and complement....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geha RS,Milgrom H,Broff M,Alpert S,Martin S,Yunis EJ

更新日期：1979-08-01 00:00:00

abstract：:This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs were tested for induction of the IL-8 promoter. A number of genes, including those for cytokines, receptors, adapters, kinases, and transcription factors, were i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iourgenko V,Zhang W,Mickanin C,Daly I,Jiang C,Hexham JM,Orth AP,Miraglia L,Meltzer J,Garza D,Chirn GW,McWhinnie E,Cohen D,Skelton J,Terry R,Yu Y,Bodian D,Buxton FP,Zhu J,Song C,Labow MA

更新日期：2003-10-14 00:00:00

abstract：:Dendritic cell (DC) lectins mediate the recognition, uptake, and processing of antigens, but they can also be coopted by pathogens for infection. These distinct activities depend upon the routing of antigens within the cell. Antigens directed to endosomal compartments are degraded, and the peptides are presented on ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis CM,Zwick DB,Grim JC,Alam MM,Prost LR,Gardiner JC,Park S,Zimdars LL,Sherer NM,Kiessling LL

更新日期：2019-07-23 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) receptor controls a pathway supporting the differentiation and survival of a wide range of neural cell types during development and in adulthood. Cardiotrophin-like cytokine (CLC)-cytokine-like factor 1 (CLF) composite cytokine is a second ligand for the CNTF alpha-component receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousseau F,Gauchat JF,McLeod JG,Chevalier S,Guillet C,Guilhot F,Cognet I,Froger J,Hahn AF,Knappskog PM,Gascan H,Boman H

更新日期：2006-06-27 00:00:00

abstract：:The α-proteobacterium Sinorhizobium meliloti establishes a chronic intracellular infection during the symbiosis with its legume hosts. Within specialized host cells, S. meliloti differentiates into highly polyploid, enlarged nitrogen-fixing bacteroids. This differentiation is driven by host cells through the productio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penterman J,Abo RP,De Nisco NJ,Arnold MF,Longhi R,Zanda M,Walker GC

更新日期：2014-03-04 00:00:00

abstract：:The DC and DX subregions of the human major histocompatibility complex (MHC) have been cloned from a cosmid library made from a human B-cell line, Priess. The DC subregion, 48 kilobases, includes the DC alpha and DC beta genes. A second DC-like region, the DX subregion, 35 kilobases, contains the DX alpha gene and a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada K,Boss JM,Prentice H,Spies T,Mengler R,Auffray C,Lillie J,Grossberger D,Strominger JL

更新日期：1985-05-01 00:00:00

abstract：:Twelve zeolitic imidazolate frameworks (ZIFs; termed ZIF-1 to -12) have been synthesized as crystals by copolymerization of either Zn(II) (ZIF-1 to -4, -6 to -8, and -10 to -11) or Co(II) (ZIF-9 and -12) with imidazolate-type links. The ZIF crystal structures are based on the nets of seven distinct aluminosilicate zeo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KS,Ni Z,Côté AP,Choi JY,Huang R,Uribe-Romo FJ,Chae HK,O'Keeffe M,Yaghi OM

更新日期：2006-07-05 00:00:00

abstract：:The thrombogenicity of three highly purified proteases (thrombin, activated Factor X, and activated Factor IX) was determined quantitatively in an animal model. The minimal amounts required to produce a standard score 4 thrombus were 1.1 nmol for thrombin, 0.12 nmol for activated Factor X, and 0.018 nmol for activated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gitel SN,Stephenson RC,Wessler S

更新日期：1977-07-01 00:00:00

abstract：:Reinstatement of neural activity is hypothesized to underlie our ability to mentally travel back in time to recover the context of a previous experience. We used intracranial recordings to directly examine the precise spatiotemporal extent of neural reinstatement as 32 participants with electrodes placed for seizure m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaffe RB,Kerr MS,Damera S,Sarma SV,Inati SK,Zaghloul KA

更新日期：2014-12-30 00:00:00

abstract：:The protein dystrophin, normally found on the cytoplasmic surface of skeletal muscle cell membranes, is absent in patients with Duchenne muscular dystrophy as well as mdx (X-linked muscular dystrophy) mice. Although its primary structure has been determined, the precise functional role of dystrophin remains the subjec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrof BJ,Shrager JB,Stedman HH,Kelly AM,Sweeney HL

更新日期：1993-04-15 00:00:00

abstract：:Translocations involving chromosome band 11q23, found in acute lymphoid and myeloid leukemias, disrupt the MLL gene. This gene encodes a putative transcription factor with homology to the zinc fingers and other domains of the Drosophila trithorax gene product and to the "AT-hook" motif of high mobility group proteins....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeleznik-Le NJ,Harden AM,Rowley JD

更新日期：1994-10-25 00:00:00

abstract：:Serpentine barrens represent extreme hazards for plant colonists. These sites are characterized by high porosity leading to drought, lack of essential mineral nutrients, and phytotoxic levels of metals. Nevertheless, nature forged populations adapted to these challenges. Here, we use a population-based evolutionary ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold BJ,Lahner B,DaCosta JM,Weisman CM,Hollister JD,Salt DE,Bomblies K,Yant L

更新日期：2016-07-19 00:00:00

abstract：:Whether and how human populations exposed to the agricultural revolution are still affected by Darwinian selection remains controversial among social scientists, biologists, and the general public. Although methods of studying selection in natural populations are well established, our understanding of selection in hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Courtiol A,Pettay JE,Jokela M,Rotkirch A,Lummaa V

更新日期：2012-05-22 00:00:00

abstract：:Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Y,Choi UB,Zhang Y,Zhao M,Pfuetzner RA,Wang AL,Diao J,Brunger AT

更新日期：2016-08-09 00:00:00

abstract：:Relatively little is known about the biochemical mechanisms through which the Epstein-Barr virus latent infection integral membrane protein 1 (LMP1) transmembrane domains cause constitutive LMP1 aggregation and continuous cytoplasmic C terminus-mediated signal transduction. We now evaluate the role of the three consec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Luftig M,Soni V,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:The biological significance of DNA amplification in cancer is thought to be due to the selection of increased expression of a single or few important genes. However, systematic surveys of the copy number and expression of all genes within an amplified region of the genome have not been performed. Here we have used a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monni O,Barlund M,Mousses S,Kononen J,Sauter G,Heiskanen M,Paavola P,Avela K,Chen Y,Bittner ML,Kallioniemi A

更新日期：2001-05-08 00:00:00

abstract：:We have investigated the interaction of human cytomegalovirus (CMV) with cultured primary granulocyte-macrophage progenitors, a suspected natural site of viral latency, and have established conditions for latent infection and reactivation in this cell population. Progenitor cells from human fetal liver or bone marrow ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo K,Kaneshima H,Mocarski ES

更新日期：1994-12-06 00:00:00

abstract：:Scores of homeobox gene-encoded transcription factors are expressed in a definite spatiotemporal pattern during embryogenesis and regulate a series of as yet unidentified target genes to help coordinate the morphogenetic process. We have suggested that homeobox gene products modulate the expression of adhesion molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones FS,Holst BD,Minowa O,De Robertis EM,Edelman GM

更新日期：1993-07-15 00:00:00

abstract：:A selenium-containing protein, selenoprotein A, is an essential component of the clostridial glycine reductase complex. This enzyme complex catalyzes the reductive deamination of glycine, which is coupled to the esterification of orthophosphate resulting in the formation of ATP. Sequence information was obtained by au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sliwkowski MX,Stadtman TC

更新日期：1988-01-01 00:00:00

abstract：:By using clones of murine T cells reactive with alloantigens as well as soluble antigens, it has been possible to demonstrate that Ia antigens, Ir gene phenomena (defined as the ability of immune T cells to recognize antigen), and mixed lymphocyte reaction (MLR)-stimulating determinants encoded within the I-A subregio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fathman CG,Kimoto M,Melvold R,David CS

更新日期：1981-03-01 00:00:00

abstract：:General control nonderepressible 2 (GCN2) plays a major role in the cellular response to amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor growth, the contribution of GCN2 to cancer cell survival and proliferation is poorly understood. In this study, we generated GCN2 inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura A,Nambu T,Ebara S,Hasegawa Y,Toyoshima K,Tsuchiya Y,Tomita D,Fujimoto J,Kurasawa O,Takahara C,Ando A,Nishigaki R,Satomi Y,Hata A,Hara T

更新日期：2018-08-14 00:00:00

abstract：:We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of mycoplasmas by alveolar macrophages (AMs) from resistant C57BL/6 mice through a nitric oxide (.NO)-dependent mechanism. Herein, SP-A-deficient [SP-A(-/-)] and inducible.NO synthase-deficient [iNOS(-/-)] mice were infected intranasal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickman-Davis J,Gibbs-Erwin J,Lindsey JR,Matalon S

更新日期：1999-04-27 00:00:00