Abstract:
:Human T lymphocytes were shown to proliferate in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-HLA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with anti-DRw antisera and complement. Macrophages pulsed for 18 hr with antigen and then washed were capable of triggering T-cell proliferation. Addition of anti-DRw but not anti-HLA (A and B loci) antisera during the pulse period inhibited the macrophages' ability to trigger T-cell proliferation. The data obtained indicate that human T cells recognize and proliferate in response to antigen presented by the macrophages in association with Ia-like antigens.
journal_name
Proc Natl Acad Sci U S Aauthors
Geha RS,Milgrom H,Broff M,Alpert S,Martin S,Yunis EJdoi
10.1073/pnas.76.8.4038keywords:
subject
Has Abstractpub_date
1979-08-01 00:00:00pages
4038-41issue
8eissn
0027-8424issn
1091-6490journal_volume
76pub_type
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