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Methylxanthine-induced escalation: a propagated wave phenomenon observed in skeletal muscle developing in culture.

Abstract：

:Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin; the effect on escalation is not. Escalation is prevented by removal of external Ca(++) or by the addition of tetracaine.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Coleman AW,Coleman JR,Griffin JD,Weltman JK,Chapman KM

doi

10.1073/pnas.69.3.613

subject

Has Abstract

pub_date

1972-03-01 00:00:00

pages

613-6

issue

3

eissn

0027-8424

issn

1091-6490

journal_volume

69

pub_type

杂志文章

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