AEV-transformed erythroleukemia cell induced differentiation: expression of specific cell membrane antigenic molecules.

Abstract:

:A simultaneous decay of the expression of Im 140 kDa, Im 150 kDa and Im 160 kDa high MW membrane antigens, concomitant with the cell proliferation arrest, was observed during erythropoietin induced differentiation of ts 34 AEV-transformed erythroid cells cultivated at the restrictive temperature. Expression of embryo-immature antigens was maintained during induced differentiation of erythroleukemia cells, but their MW shifted from 50 to 48 kDa, which corresponds to the MW of embryo-immature antigens detected on normal erythroid cells. In the absence of erythropoietin at the restrictive temperature, conditions under which the ts 34 AEV-transformed erythroid cells fail to differentiate and maintain their capacity to proliferate, the expression of high MW antigens as well as the expression of embryo-immature antigens remained unaffected. Therefore, it is shown that the expression of specific membrane antigens is modulated under conditions rendering the erythroleukemia cell differentiation process possible.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Raynaud I,Biquard JM,Chambard P,Fasciotto B,Samarut J,Blanchet JP,Krsmanovic V

doi

10.1007/BF01310975

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

213-22

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

93

pub_type

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