Abstract:
:A simultaneous decay of the expression of Im 140 kDa, Im 150 kDa and Im 160 kDa high MW membrane antigens, concomitant with the cell proliferation arrest, was observed during erythropoietin induced differentiation of ts 34 AEV-transformed erythroid cells cultivated at the restrictive temperature. Expression of embryo-immature antigens was maintained during induced differentiation of erythroleukemia cells, but their MW shifted from 50 to 48 kDa, which corresponds to the MW of embryo-immature antigens detected on normal erythroid cells. In the absence of erythropoietin at the restrictive temperature, conditions under which the ts 34 AEV-transformed erythroid cells fail to differentiate and maintain their capacity to proliferate, the expression of high MW antigens as well as the expression of embryo-immature antigens remained unaffected. Therefore, it is shown that the expression of specific membrane antigens is modulated under conditions rendering the erythroleukemia cell differentiation process possible.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Raynaud I,Biquard JM,Chambard P,Fasciotto B,Samarut J,Blanchet JP,Krsmanovic Vdoi
10.1007/BF01310975subject
Has Abstractpub_date
1987-01-01 00:00:00pages
213-22issue
3-4eissn
0304-8608issn
1432-8798journal_volume
93pub_type
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journal_title:Archives of virology
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journal_title:Archives of virology
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pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Archives of virology
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doi:10.1007/BF01314294
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journal_title:Archives of virology
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更新日期:2007-01-01 00:00:00
abstract::To establish an animal model for the newly identified Marmota Himalayana hepatovirus, MHHAV, so as to develop a better understanding of the infection of hepatitis A viruses. Five experimental woodchucks (Marmota monax) were inoculated intravenously with the purified MHHAV from wild woodchuck feces. One animal injected...
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journal_title:Archives of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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