Abstract：
:To establish an animal model for the newly identified Marmota Himalayana hepatovirus, MHHAV, so as to develop a better understanding of the infection of hepatitis A viruses. Five experimental woodchucks (Marmota monax) were inoculated intravenously with the purified MHHAV from wild woodchuck feces. One animal injected with PBS was defined as a control. Feces and blood were routinely collected. After the animals were subjected to necropsy, different tissues were collected. The presence of viral RNA and negative sense viral RNA was analyzed in all the samples and histopathological and in situ hybridization analysis was performed for the tissues. MHHAV infection caused fever but no severe symptoms or death. Virus was shed in feces beginning at 2 dpi, and MHHAV RNA persisted in feces for ~2 months, with a biphasic increase, and in blood for ~30 days. Viral RNA was detected in all the tissues, with high levels in the liver and spleen. Negative-strand viral RNA was detected only in the liver. Furthermore, the animals showed histological signs of hepatitis at 45 dpi. MHHAV can infect M. monax and is associated with hepatic disease. Therefore, this animal can be used as a model of HAV pathogenesis and to evaluate antiviral and anticancer therapeutics.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Yu JM,Li LL,Xie GC,Zhang CY,Ao YY,Duan ZJdoi
10.1007/s00705-018-3715-zsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
1187-1193issue
5eissn
0304-8608issn
1432-8798pii
10.1007/s00705-018-3715-zjournal_volume
163pub_type
杂志文章abstract：:HSV-2 infections suppress the antibody response to HSV-1 but do not impair the mouse cytomegalo virus (MCMV) antibody generating system. In contrast, the sheep red blood cell (SRBC) IgM response is impaired by preinfections with HSV-2 but not with HSV-1. From the time kinetics of this suppression it can be concluded t...
journal_title：Archives of virology
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journal_title：Archives of virology
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journal_title：Archives of virology
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doi：10.1007/BF01315635
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01313814
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pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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