Abstract:
:The newly identified 2019 novel coronavirus (SARS-CoV-2) has become a public health concern globally posing a significant threat to human health and economy and creating an unprecedented crisis in all spheres of the global life. Emergence of new genotypes of SARS-CoV during the last few years has pointed out the limited efficacy of available vaccines and antivirals, constraining the global response to the COVID-19 outburst to largely monitoring/containment. There is high priority for treatment regimes and new potential therapeutic and vaccine strategies. Several candidates have shown promising outcomes in various in vitro and in vivo models. In addition, clinical trials are in progress to test conceivable therapies showing promising outcomes in various in vivo studies. Unfortunately, very little information is available in the scientific scope which offers details to the diverse strategies being targeted to fight the pandemic, particularly with respect to the molecular targets. This review article summarizes and highlights the ongoing advances and approaches that are being carried out across the globe in designing vaccines and novel therapeutics, with particular reference to the previous knowledge gained from other viral infections like with the earlier SARS and MERS-CoV. A detailed knowledge may pave the way to combat this pandemic COVID-19 as well as prevent similar deadly epidemics in future.
journal_name
Curr Microbioljournal_title
Current microbiologyauthors
Bhattacharjee A,Saha M,Halder A,Debnath A,Mukherjee Odoi
10.1007/s00284-020-02310-xsubject
Has Abstractpub_date
2021-01-03 00:00:00eissn
0343-8651issn
1432-0991pii
10.1007/s00284-020-02310-xpub_type
杂志文章,评审abstract::We present a novel light-dependent metabolism of an aromatic compound (trans-cinnamate) that is assimilatory rather than dissimilatory. Light-dependent assimilation of trans-cinnamate was observed by both growing and resting cells of Rhodobacter sphaeroides OU5. Trans-cinnamate assimilation could be correlated with si...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-006-0440-8
更新日期:2007-06-01 00:00:00
abstract::Francisella tularensis, the causative agent of tularemia, has attained the status of one of the high priority agents that could be used in the act of bioterrorism. Currently, there is no licensed vaccine for this highly infectious intracellular pathogen. Being a listed 'Category A' agent of the U.S. Center for Disease...
journal_title:Current microbiology
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abstract::One hundred and twenty-nine Vibrio anguillarum serogroup O2 strains were compared by slide agglutination and Western blotting for their lipopolysaccharide (LPS) structure. The strains showed six different LPS profiles, four different reaction patterns in Western blotting, and four different kinds of reaction in slide ...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s002849900141
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abstract::Variable-number-of-tandem-repeats (VNTR) markers are increasingly being used in population genetic studies of bacteria. They were recently developed for Pasteuria ramosa, an endobacterium that infects Daphnia species. In the present study, we genotyped P. ramosa in 18 infected hosts from the United Kingdom, Belgium, a...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-008-9104-1
更新日期:2008-05-01 00:00:00
abstract::Based on the genomic sequence and cDNA library screening, the cDNA sequence encoding an alpha-amylase was cloned from the filamentous white-rot fungus Phanerochaete chrysosporium and designated as pcamy1. Alignment results showed that the predicted protein has up to 43% amino acid homology to the known alpha-amylases ...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-006-0600-x
更新日期:2007-08-01 00:00:00
abstract::Putative penicillin-binding proteins (PBPs) were identified in the genome of the Burkholderia cenocepacia strain J2315 based on homology to E. coli PBPs. The three sequences identified as homologs of E. coli PBP1a, BCAL2021, BCAL0274, and BCAM2632, were cloned and expressed as His(6)-tagged fusion proteins in E. coli....
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-009-9537-1
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abstract::To well understand the community structure and composition of mesophilic microorganisms in anaerobic system fed with PTA wastewater, an up-flow anaerobic fixed bed reactor was continuously run at 33 and 37 °C for 75 and 60 days, respectively. Both fluorescence in situ hybridization analysis and 454-pyrosequencing were...
journal_title:Current microbiology
pub_type: 杂志文章
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abstract::Nitric oxide synthase (NOS), the enzyme responsible for the production of endogenous nitric oxide from arginine, has been recently discovered in a number of Gram-positive bacteria. While bacterial NOS has been implicated in mediating nitrosative stress, much remains unknown about the functional role of endogenous nitr...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-011-0039-6
更新日期:2012-02-01 00:00:00
abstract::Flammulina velutipes is a potentially excellent fungus to study basic mechanisms of basidiomycete mycelium biology. To provide a better understanding of the mechanism of hyphae growth and fruit-body formation, the biological functions of the differentially abundant proteins between the fruiting dikaryon and the non-fr...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-016-1164-z
更新日期:2017-01-01 00:00:00
abstract::Biocides play an important role in healthcare-associated infection control by either minimizing or preventing microorganism dissemination. This study evaluated the susceptibility of Pseudomonas aeruginosa clinical isolates to a quaternary ammonium (QAC) disinfectant and antibiotics, and verified the presence of qacEΔ1...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-011-9934-0
更新日期:2011-07-01 00:00:00
abstract::Escherichia coli (E. coli) has been widely used as a host organism for producing recombinant proteins such as biocatalysts, antibody fragments, and therapeutic hormones. To enhance recombinant protein production, many E. coli strains have been genetically engineered on practical purposes. In this study, we developed t...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-019-01730-8
更新日期:2019-11-01 00:00:00
abstract::The ability of Burkholderia sp. VUN10013 to degrade anthracene in microcosms of two acidic Thai soils was studied. The addition of Burkholderia sp. VUN10013 (initial concentration of 10(5) cells g(-1) dry soil) to autoclaved soil collected from the Plew District, Chanthaburi Province, Thailand, supplemented with anthr...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-008-9157-1
更新日期:2008-08-01 00:00:00
abstract::The search for a vaccine capable of conferring heterologous protection, through the identification of conserved and cross-protective antigens, remains an ongoing priority in leptospirosis research. In the present study, an in silico analysis was used to identify potentially protective lipoproteins from Leptospira inte...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-010-9865-1
更新日期:2011-04-01 00:00:00
abstract::Biofouling leads to water quality deterioration and higher maintenance cost for cleaning of membranes. The present study has demonstrated the application of a biomolecule (vanillin) in scrubbing and destabilizing biofilms of drinking water reverse osmosis (RO) membrane module in lab scale reactor set-up. Reverse osmos...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-020-02003-5
更新日期:2020-09-01 00:00:00
abstract::Root colonization and diversity of arbuscular mycorrhizal fungi (AMF) were analyzed in plants growing in fly ash pond. Eight species could be separated morphologically, while phylogenetic analyses after PCR amplification of the ITS region followed by RFLP and sequencing revealed seven different AM fungal sequence type...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-011-9974-5
更新日期:2011-09-01 00:00:00
abstract::Agaricus bisporus (J. E. Lange) Imbach, well known as the common cultivated mushroom or white button mushroom, is widely cultivated all over the world. We used iTRAQ-MS/MS (i.e., isobaric tags for relative and absolute quantification-coupled two-dimensional liquid chromatography-tandem mass spectrometry) to identify p...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-017-1225-y
更新日期:2017-05-01 00:00:00
abstract::The facultative anaerobe Pantoea sp. strain A-13, isolated from ornithogenic soil of Dewart Island (Frazier Islands), Antarctica, produced glycolipid biosurfactants when grown on n-paraffins or kerosene as the sole source of carbon and energy. Hemolysis of erythrocytes, growth inhibition of Bacillus subtilis, and thin...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-006-0345-6
更新日期:2007-02-01 00:00:00
abstract::Marine subsurface sediments represent a novel archaeal biosphere with unknown physiology. To get to know the composition and ecological roles of the archaeal communities within the sediments of the Pearl River Estuary, Southern China, the diversity and vertical distribution of active archaea in a sediment core were ch...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-013-0320-y
更新日期:2013-07-01 00:00:00
abstract::Bacterial communities communicate, regulate and coordinate their cooperative activities and physiological process by releasing, sensing and responding to small diffusible signal molecules such as acyl homoserine lactones (AHLs), auto-inducing oligo-peptides (AIPs) and autoinducer-2, a process referred to as Quorum sen...
journal_title:Current microbiology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
abstract::Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It was firstly isolated from sputum specimens of infants with central nervous system diseases in California in 1969, and has been repeatedly reported in various parts of the world, especially in the Asia-Pacific region. EV71 3C protein is...
journal_title:Current microbiology
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
abstract::The commencement of intracellular protease synthesis was studied by gelatin zymography in Bacillus thuringiensis ( Btk) HD1, Btk HD73, and a protease-deficient mutant Btk-q derived from the former strain. By gelatin zymography, a 92-kDa protease was detected first at 3 h of sporulation, which continued until 48 h, whe...
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pub_type: 杂志文章
doi:10.1007/s00284-002-3767-9
更新日期:2002-12-01 00:00:00
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journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-014-0707-4
更新日期:2015-02-01 00:00:00
abstract::Nine structurally similar macrolide antibiotics were tested at a concentration of 0.5 microg/ml for their relative inhibitory effects on ribosome functions in Staphylococcus aureus cells. Eight of the compounds examined inhibited protein synthesis at this concentration. Seven of the nine compounds were also effective ...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s002849900402
更新日期:1998-12-01 00:00:00
abstract::Phage H188, a novel Vibrio kanaloae phage, was isolated from the surface water of Yellow Sea. Morphological analysis by transmission electron microscopy reveals that it belongs to the family Myoviridae. Present result suggests that the phage is stable at pH between 4.0 and 12.0. No significant difference in phage tite...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-015-0984-6
更新日期:2016-05-01 00:00:00
abstract::The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is responsible for nosocomial and community-acquired infections. Hence, rapid and accurate laboratory diagnosis of MRSA is a vital constituent of control measures. The present study evaluated five different methods for the identification of MRSA. A to...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-009-9567-8
更新日期:2010-07-01 00:00:00
abstract::A novel bacterium, designated U33(T), was isolated from a soil sample collected in Mykhailyky, Poltavs'ka oblast, Ukraine. The bacterium was aerobic, Gram-positive, spore-forming, and consists of motile rods. The taxonomic position of strain U33(T) was studied by a polyphasic approach, and the results clearly showed t...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-015-0930-7
更新日期:2016-02-01 00:00:00
abstract::Iturin A is a very important cyclic lipopeptide produced by several B. subtilis strains and has large commercial and therapeutic application potentials but its production on industrial scale has not been realized yet. In the present study, we have observed that the strain ET-1 of Bacillus subtilis, a producer of Ituri...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-019-01764-y
更新日期:2019-12-01 00:00:00
abstract::The immunosuppressant leflunomide (LFM) inhibits the growth of cytokine-stimulated proliferation of lymphoid cells in vitro and also inhibits the growth of eukaryotic microorganism, Saccharomyces cerevisiae. As a first step to elucidate the molecular mechanism of LFM action in human, yeast gene which suppresses the an...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s002840010267
更新日期:2001-08-01 00:00:00
abstract::Lipids contribute significantly to the pathogenesis of fungal infectious diseases and an understanding of lipid metabolism occurring in fungal pathogens can help the development of more efficient antifungal therapeutic strategies. In this study, the effect of culture age on the distribution of fatty acids among differ...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/s00284-007-9052-1
更新日期:2008-02-01 00:00:00
abstract::The present paper summarizes the serotyping scheme of the fish pathogenic bacterium Vibrio anguillarum and defines seven additional O-serogroups. Strains, collected in our laboratories that were nontypable with antisera against the previously defined 16 O-serotypes, were used for generating new antisera and were chara...
journal_title:Current microbiology
pub_type: 杂志文章
doi:10.1007/pl00006784
更新日期:1999-03-01 00:00:00