Abstract：
:Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It was firstly isolated from sputum specimens of infants with central nervous system diseases in California in 1969, and has been repeatedly reported in various parts of the world, especially in the Asia-Pacific region. EV71 3C protein is a 183 amino acid cysteine protease that can cleave most structural and non-structural proteins of EV71. Based on the analysis and understanding of EV71 3C protease, it is helpful to study and treat diseases caused by EV71 virus infection. The EV71 3C protease promotes virus replication by cleaving EV71 synthesis or host proteins. Moreover, EV71 3C protease inhibits the innate immune system and causes apoptosis. At present, in order to deal with the damage caused by the EV71, it is urgent to develop antiviral drugs targeting 3C protease. This review will focus on the structure, function, and mechanism of EV71 3C protease.
journal_name
Curr Microbioljournal_title
Current microbiologyauthors
Wen W,Qi Z,Wang Jdoi
10.1007/s00284-020-02082-4subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1968-1975issue
9eissn
0343-8651issn
1432-0991pii
10.1007/s00284-020-02082-4journal_volume
77pub_type
杂志文章,评审abstract：:One hundred and twenty-nine Vibrio anguillarum serogroup O2 strains were compared by slide agglutination and Western blotting for their lipopolysaccharide (LPS) structure. The strains showed six different LPS profiles, four different reaction patterns in Western blotting, and four different kinds of reaction in slide ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002849900141
更新日期：1997-01-01 00:00:00
abstract：:Strain NHI-24(T) was isolated from forest soil by a polycarbonate membrane transwell plate. It is a Gram-negative, rod-shaped, non-motile, non-spore-forming bacterium. Phylogenetic analysis based on 16S rRNA gene sequence data indicated that strain NHI-24(T) is closely related to members of the genus Niabella: N. dril...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-014-0565-0
更新日期：2014-08-01 00:00:00
abstract：:Salinity, a serious environmental pressure on crop production, might be counteracted by free-living and symbiotic inoculants entailing positive synergistic effects. Enhancement in nutrient uptake and/or production of antioxidants under the stress condition, can improve plant growth and yield. In this study, inoculatio...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-020-02034-y
更新日期：2020-09-01 00:00:00
abstract：:We undertook the issue of the distribution of intracellular bacteria among Oribatida (Acari). Six genera of bacteria were detected by PCR and Sanger DNA sequencing: Wolbachia, Cardinium, Rickettsia, Spiroplasma, Arsenophonus, and Hamiltonella. Our research, for the first time, revealed the presence of Cardinium in Mic...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-019-01717-5
更新日期：2019-09-01 00:00:00
abstract：:This paper presents the results of studies on the activity of extra-cellular enzymes in soil-willow vegetation filter soil which is used in the post-treatment of household sewage in an onsite wastewater treatment system located in central Poland. Wastewater is discharged from the detached house by gravity into the ons...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-012-0230-4
更新日期：2012-12-01 00:00:00
abstract：:Microbial populations in indoor environments, where we live and eat, are important for public health. Various bacterial species reside in the kitchen, and refrigerators, the major means of food storage within kitchens, can be a direct source of food borne illness. Therefore, the monitoring of microbiota in the refrige...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-013-0401-y
更新日期：2013-11-01 00:00:00
abstract：:A gene argH, encoding argininosuccinate lyase (ASL), has been cloned from a cosmid library of the filamentous cyanobacterium Nostoc sp. strain PCC 73102. The argH open reading frame encodes a protein comprised of 461 amino acids with a calculated molecular mass of 51,349 Da. Protein sequence comparisons reveal signifi...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002840010298
更新日期：2001-10-01 00:00:00
abstract：:Antimicrobial-resistant Klebsiella pneumoniae represent a global public health concern. K. pneumoniae strains isolated during 2010 and 2014-2016 within a single hospital of Molise Region, Central Italy, were analyzed testing antimicrobial susceptibility, clonality by pulsed-field gel electrophoresis (PFGE) and random ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-018-1475-3
更新日期：2018-08-01 00:00:00
abstract：:Pathogens have evolved an array of strategies to establish a productive infection. The extracellular proteins secreted by pathogens are one of unique mechanisms to evade the host innate immune response. Many secretory proteins transported by the bacterial secretion systems have been widely investigated in Salmonella. ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-020-02201-1
更新日期：2020-11-01 00:00:00
abstract：:Degradation of n-alkanes in diesel oil by Pseudomonas aeruginosa strain WatG (WatG) was verified in soil microcosms. The total petroleum hydrocarbon (TPH) degradation level in two bioaugmentation samples was 51% and 46% for 1 week in unsterilized and sterilized soil microcosms, respectively. The TPH degradation in the...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-005-0133-8
更新日期：2006-03-01 00:00:00
abstract：:In the present study, probiotic, safety and functional characteristics of eight indigenous bifidobacterial isolates were compared to identify suitable strains for functional food application. Among the isolates, six strains of Bifidobacterium longum and one each of Bifidobacterium breve and Bifidobacterium bifidum wer...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-018-1615-9
更新日期：2019-03-01 00:00:00
abstract：:The mechanisms used by Campylobacter jejuni to colonize the (chicken) intestinal tract have not been defined. In this study, we obtained evidence that in the presence of chicken serum and mucus, C. jejuni secreted proteins that may play a role in the colonization of chicken gut (Campylobacter invasion antigen = Cia). ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-006-0295-z
更新日期：2007-03-01 00:00:00
abstract：:DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane) is one of the pesticides that are hazardous for the environment and human health. Effective environmental-friendly treatment using co-cultures of fungi and bacteria is needed. In this study, the bacteria Bacillus subtilis at various volumes of 1, 3, 5, 7, and 10 mL (...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-017-1286-y
更新日期：2017-09-01 00:00:00
abstract：:Thirty-one Listeria strains were tested for sensitivity to four class IIa bacteriocins, namely, enterocin A, mesentericin Y105, divercin V41, and pediocin AcH, and to nisin A. Class IIa bacteriocins displayed surprisingly similar antimicrobial patterns ranging from highly susceptible to fully resistant strains, wherea...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002840010081
更新日期：2000-07-01 00:00:00
abstract：:Thirteen clinical isolates of Pasteurella multocida from a variety of different animals and humans were examined for their ability to produce lipase. Lipase substrates used included Tween 20, Tween 40, Tween 80, and Tween 85. Lipase activity was detected in the filtrates of organisms grown to the exponential phase in ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002849910061
更新日期：2000-05-01 00:00:00
abstract：:The gene organization and nucleotide sequence of the type A and B BoNT-gene clusters in Clostridium botulinum strain NCTC 2916 were studied. The aim was to clarify the organization of genes within C. botulinum type A strains possessing an unexpressed BoNT/B gene. The BoNT/A-gene cluster includes genes encoding BoNT, N...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002849900299
更新日期：1998-04-01 00:00:00
abstract：:The aim of this study is to investigate the combination of cefepime and sulbactam. Sulbactam, when administered , will effectively inhibit all Extended-spectrum beta lactamases (ESBLs) of the microorganism, while cefepime will inhibit the growth of the resistant microorganisms since it will not be hydrolyzed by OXA-48...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-020-02094-0
更新日期：2020-09-01 00:00:00
abstract：:The cluster of genes encoding components of the progenitor botulinum neurotoxin complex has been mapped and cloned in Clostridium botulinum type G strain ATCC 27322. Determination of the nucleotide sequence of the region has revealed open reading frames encoding nontoxic components of the complex, upstream of the gene...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002849900240
更新日期：1997-10-01 00:00:00
abstract：:Gram-negative bacteria are generally more tolerant to disinfectants than Gram-positive bacteria due to outer membrane (OM) barrier, but the tolerant mechanism is not well characterized. We have utilized comparative proteomic methodologies to characterize the OM proteins of E. coli K-12 K99+ in response to phenol stres...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-010-9786-z
更新日期：2011-03-01 00:00:00
abstract：:A common activity in the global search for useful Cry toxins is the microscopic screening of bacterial colonies for the presence of Bacillus thuringiensis. High-throughput screens require that aliquots from large numbers of colonies be arrayed on a microscopic slide. However, precisely placing a small amount of bacter...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-015-0870-2
更新日期：2015-09-01 00:00:00
abstract：:The Gluconobacter oxydans M5 with disruption of the pyrroloquinoline quinine-dependent membrane-bound aldehyde dehydrogenase (ALDH) was used for the oxidation of benzyl alcohol. The selectivity toward benzaldehyde showed an obvious increase for the engineered strain, which reached the 67.3%, while the wild strain had ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-010-9831-y
更新日期：2011-04-01 00:00:00
abstract：:Pectin is a diverse polysaccharide comprising of polygalacturonic acid, rhamnogalactouronan, and neutral polysaccharides (arabinan and arabinogalactan) as side chains or branches. They are resistant to salivary amylase and gastric juice. In the present study the prebiotic potentials of different pectic derived substra...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-019-01781-x
更新日期：2019-12-01 00:00:00
abstract：:An endolithic bacterium, strain RSBr-1, was isolated from the inside of a piece of red sandstone from coastal areas of Scotland. RSBr-1 was gram negative, oxidase and catalase positive, and cells were non-motile rods. Sodium was required for growth. The optimum sodium chloride concentration and pH for growth were 4% a...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-003-4006-8
更新日期：2003-11-01 00:00:00
abstract：:Physiological alterations and regulation of heterocyst and nitrogenase formation have been studied in Het(-) Fix(-) mutant strain of diazotrophic cyanobacterium Anabaena variabilis. Het(-) Fix(-) mutant strain of A. variabilis has been isolated by N-methyl-N'-nitro-N"-nitrosoguanidine (NTG) mutagenesis and was screene...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-002-3756-z
更新日期：2002-11-01 00:00:00
abstract：:Betel vine is an edible creeper used in folk medicine to aid digestion since time immemorial. It is an ideal candidate deemed for the bioprospection of endophytic microorganisms with valuable attributes. This study aimed at the characterization of potential bacteria from fermented betel leaves. We report the presence ...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-020-02270-2
更新日期：2021-01-01 00:00:00
abstract：:Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections. Alginate of mucoid Pseudomonas aeruginosa biofilms is considered an important virulence factor which contributes to the resistance to antibiotics. Traditionally, ambrox...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-008-9142-8
更新日期：2008-07-01 00:00:00
abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) displays important functional diversity in mammalian and plants. So far, however, studies on GAPDH have not included the halotolerant, unicellular green alga Dunaliella salina. In the present study, a GAPDH cDNA was cloned and sequenced from D. salina. It was 1394 bp lo...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-008-9333-3
更新日期：2009-05-01 00:00:00
abstract：:The cyt1Aa gene from Bacillus thuringiensis subsp. israelensis (Bti), whose product synergizes other mosquitocidal toxins, and functions as a repressor of resistance developed by mosquitoes against Bacilli insecticides, was introduced into the aquatic Gram-negative bacterium Asticcacaulis excentricus alongside the cry...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-006-0352-7
更新日期：2007-01-01 00:00:00
abstract：:Helicobacter pylori infection increases the risk of cardiovascular diseases besides leading to duodenal and gastric peptic ulcerations. H. pylori cysteine-rich protein B (HcpB) is a disulfide-rich repeat protein that belongs to the family of Sel1-like repeat proteins. HcpB contains four pairs of anti-parallel alpha he...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s00284-010-9803-2
更新日期：2011-03-01 00:00:00
abstract：:Unicellular green algae, like Chlorella, offer a potentially useful system for the expression of heterologous proteins. However, the development of Chlorella as a bioreactor has been delayed owing to the lack of a stable transformation technique. Here we report on the use of micro-projectile bombardment to introduce t...
journal_title：Current microbiology
pub_type： 杂志文章
doi：10.1007/s002849900268
更新日期：1997-12-01 00:00:00
