Abstract：
:Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections. Alginate of mucoid Pseudomonas aeruginosa biofilms is considered an important virulence factor which contributes to the resistance to antibiotics. Traditionally, ambroxol is widely used in newborns with lung problems as a mucolytic agent and antioxidant agent as well. And there are few studies that demonstrated the anti-biofilm activity of ambroxol. In this study, we found that ambroxol can affect the structure of mucoid Pseudomonas aeruginosa biofilms. Further, we found that ambroxol reduces the production of alginate, the expression of the important genes and the activity of key enzyme guanosine diphospho-D-mannose dehydrogenase (GDP-mannose dehydrogenase; GMD) which were involved in alginate biosynthesis.
journal_name
Curr Microbioljournal_title
Current microbiologyauthors
Li F,Yu J,Yang H,Wan Z,Bai Ddoi
10.1007/s00284-008-9142-8subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1-7issue
1eissn
0343-8651issn
1432-0991journal_volume
57pub_type
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