Abstract：
:In this study, we employed Pectin (PC) as a matrix that is hybridized with three different nucleobase (NB) units (cytosine, thymine, uracil) to generate pectin-nucleobase(PC-NB) biocomposite films stabilized through bio-multiple hydrogen bonds (BMHBs) as drug carrier for anticancer 5-Fluorouracil (5-FU). Prepared biocomposite films were characterized by Fourier Transform Infra-red Spectroscopy (FTIR), X-ray Diffraction (XRD), Thermogravimmetry Analysis (TGA) and Scanning Electron Microscope (SEM). Mechanical and sorption properties were also evaluated. In vitro drug release performed in both acidic pH 1.2 (stomach pH) and alkaline pH 7.4 (intestinal pH) showed that incorporation of nucleobases into pectin significantly restricted release rate of 5-FU particularly under acidic condition (pH 1.2). Hemolysis assays demonstrated that PC-NB-5-FU biocomposite film drug carriers were hemocompatible. Confocal microscope analysis indicates facilitated cellular uptake of PC-NB-5-FU film in HT-29 colon cancer cell line, which in turn result in a higher potential of apoptosis. Confocal imaging of fluorescent live/dead cell indicators and MTT assay outcomes, both demonstrated significant decreases in cellular viability of PC-NB-5-FU biocomposite films. Collectively, our findings indicate that this PC-NB-5-FU biocomposite films can be conferred as a proficient formulation for targeted delivery of colon cancer drugs.
journal_name
J Mech Behav Biomed Materauthors
Tamilselvi S,Kavitha R,Usharani M,Mumjitha M,Mohanapriya S,MohanaPriya Sdoi
10.1016/j.jmbbm.2020.104266subject
Has Abstractpub_date
2021-03-01 00:00:00pages
104266eissn
1751-6161issn
1878-0180pii
S1751-6161(20)30803-1journal_volume
115pub_type
杂志文章abstract：:As a supplement to our investigation into R-curves in a short-fiber reinforced dental resin composite, we investigate the effects of 2-months water storage. Water is known to degrade the siloxane bonds linking matrix and fillers, which has been suggested to decrease the fracture toughness in conventional resin composi...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103674
更新日期：2020-04-01 00:00:00
abstract：:Sylgard((R)) is a biocompatible elastomer which has been widely used in biomedical applications including in simulations of the mechanical response of soft tissues and mechanotransduction investigations. In this study the effect of fabrication parameters including base to curing agent ratio and curing time on the mech...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2010.04.003
更新日期：2010-08-01 00:00:00
abstract：:The aim of the present work was twofold: to prepare biphasic magnesium fluorapatite (MFA) composites with different amounts of alumina using a two-step sintering process, and to evaluate the effects of various amounts of alumina on the mechanical properties, phase stability, and densification of the composite samples....
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.08.004
更新日期：2014-12-01 00:00:00
abstract：:In this study, the relationship between deformation mechanism and rolling reductions was investigated, and the effects of deformation reductions on the microstructure and mechanical properties of the alloys both cold rolled and aged were revealed. It was found that the equiaxed β grains of the Ti-30Nb-5Ta-6Zr alloy ha...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.06.006
更新日期：2013-11-01 00:00:00
abstract：:Intervertebral discs (IVDs) maintain flexibility of the spine and bear mechanical load. Annulus fibrosus (AF) defects are associated with IVD degeneration and herniation which disrupt biomechanical function and can cause pain. AF puncture injuries can induce IVD degeneration but are needed to inject therapies. Identif...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2019.03.024
更新日期：2019-07-01 00:00:00
abstract：:The purpose of this study was to evaluate LC Bead LUMI™ (40-90µm and 70-150µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial microspheres. LC Bead LUMI™ 40-90µm and 70-150µm, LC BeadM1® 70-150µm, Embozene™...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.10.034
更新日期：2018-02-01 00:00:00
abstract：:This study compared the fatigue performance and the stress distribution of endodontically treated molars restored with endocrowns obtained with lithium disilicate glass-ceramic or a polymer-infiltrated ceramic network, both processed by CAD-CAM, and direct composite restorations. Forty-eight human mandibular molars we...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2019.103401
更新日期：2019-12-01 00:00:00
abstract：:The design of meshes for the treatment of incisional hernias could benefit from better knowledge of the mechanical response of the abdominal wall and how this response is affected by the implant. The aim of this study was to characterise the mechanical behaviour of the human abdominal wall. Abdominal walls were tested...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.07.002
更新日期：2014-10-01 00:00:00
abstract：:Monolithic dental prostheses fabricated from 3 mol.% yttria-stabilized zirconia (3YZ) are becoming increasingly popular. Recently, 5 mol.% yttria-stabilized zirconia (5YZ) which significantly improves the translucency of 3YZ has been prepared. However, its mechanical and microstructural properties, especially those af...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103974
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Perfusion bioreactors are used to solve problems in critical size bone tissue engineering. Biominerizable and biocompatible nanocomposites are suitable scaffold materials for this purpose because they offer mineral components in organic carriers. Human adipose derived stem cells (ASCs) can potentially be use...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.03.022
更新日期：2015-07-01 00:00:00
abstract：:Fibrin sealant (FS) is a biomaterial that exhibits hemostatic and repairing properties. It has been successfully used as scaffolds and adhesives to improve repair and regeneration of tissues. The objective of this study was to evaluate the effect of FS in the regeneration process of bone defects in male rat tibias thr...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103662
更新日期：2020-04-01 00:00:00
abstract：:In this paper the mechanical response of the arthropod cuticle is evaluated by means of a multiscale approach including interface effects. The cuticle's elastic behavior is modeled at the nano and the micro scales by mean-field homogenization techniques. With respect to the work of Nikolov et al. (2011), the idea has ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:The purpose of this systematic review was to summarize scientific evidence that evaluates in vitro fracture and fatigue strength of occlusal veneers in different thicknesses, CAD/CAM materials, and under different aging methodologies. MATERIALS AND METHODS:An electronic search of 3 English databases (The Nat...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章,评审
doi：10.1016/j.jmbbm.2020.103948
更新日期：2020-10-01 00:00:00
abstract：:Clinical meshes used in pelvic organ prolapse (POP) repair are predominantly manufactured from monofilament polypropylene (PP). Complications from the use of these meshes in transvaginal kits, including mesh exposure and pain, have prompted two public health notifications by the FDA. The aim of this study was to compa...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND AND AIMS:The course and outcome of pregnancy is closely correlated to change of biomechanical properties of the uterine cervix. The aim of this study was to build a non-linear, fiber reinforced mechanical model of the cervix for estimation of mechanical characteristics of the cervix in early- and term-pregna...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.07.005
更新日期：2014-11-01 00:00:00
abstract：:An unusual type of mechanical behavior was registered while studying the swollen hydrogel compositions "cellulose-polyacrylamide" in the conditions of multiple cyclic compression tests with the broad variation of the deformation speed. While increasing the deformation rate the clearly seen inversion of the positions o...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.03.030
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:Limited information is available on the effect of Immediate Dentin Sealing (IDS) on the fracture strength of indirect partial posterior restorations. This study evaluated the effect of IDS on the fracture strength and failure types of two indirect restorative materials. MATERIALS AND METHODS:Standard MOD inlay...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.04.002
更新日期：2017-08-01 00:00:00
abstract：:Since the local, on demand, cancer therapy is a challenging clinical issue today, this paper presents the design, fabrication and characterization of a remotely controlled single reservoir drug delivery chip using Ionic Polymer Metal Composite (IPMC) actuator. Here, Drug release was externally programmed and controlle...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.06.034
更新日期：2018-10-01 00:00:00
abstract：:The use of an adhesive for mesh fixation in hernia repair reduces chronic pain and minimizes tissue damage in the patient. This study was designed to assess the adhesive properties of a medium-chain (n-butyl) cyanoacrylate glue applied as drops or as a spray in a biomechanical and histologic study. Both forms of glue ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.08.008
更新日期：2017-11-01 00:00:00
abstract：:Characterization of the mechanical properties of biological materials is often complicated by small volume, irregular geometry, fragility, and environmental sensitivity. Pipette aspiration and nanoindentation testing deal well with these limitations and have seen increasing use in biomaterial characterization, but lit...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.07.022
更新日期：2015-11-01 00:00:00
abstract：:In 3DP fabricating artificial bone scaffolds process, the interaction mechanism between binder and bioceramics power determines the microstructure and macro mechanical properties of Hydroxyapatite (HA) bone scaffold. In this study, we applied Molecular Dynamics (MD) methods to investigating the bonding mechanism and e...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.12.007
更新日期：2016-04-01 00:00:00
abstract：:Tissue engineering technology requires porous scaffolds, based on biomaterials, which have to mimic as closely as possible the morphological and anisotropic mechanical properties of the native tissue to substitute. Anisotropic fibrous scaffolds fabricated by template-assisted electrospinning are investigated in this s...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.104124
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:The causes of in vivo fractures of all-ceramic dental crowns are not yet fully understood. The fracture origins often occur in the cervical margin in the approximal area, but the reason for this is unclear. The aim of this study was to evaluate the fracture origin of 22 of clinically-failed alumina crowns. ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.08.006
更新日期：2016-01-01 00:00:00
abstract：:The ability to determine patient-specific mechanical properties of trabecular bone is needed for a reliable estimation of fracture risks. Tissue mechanics and material composition are important factors that contribute to trabecular bone performance, but only a few studies have investigated the post-yield behaviour of ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.04.014
更新日期：2013-08-01 00:00:00
abstract：:Hygiene products such as incontinence pads bring nonwoven fabrics into contact with users' skin, which can cause damage in various ways, including the nonwoven abrading the skin by friction. The aim of the work described here was to develop and use methods for understanding the origin of friction between nonwoven fabr...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.04.024
更新日期：2013-12-01 00:00:00
abstract：:This aim of this study is to determine the elastoplastic properties of Ni-free Al3FeSi2 intermetallic coatings grown on medical stainless steel under different experimental conditions. Elastoplastic properties are defined by the plasticity index (PI), which correlates the hardness and the Young's modulus. Special emph...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.02.018
更新日期：2015-06-01 00:00:00
abstract：:Poly (glycerol sebacate) (PGS) is a promising elastomer for use in soft tissue engineering. However, it is difficult to achieve with PGS a satisfactory balance of mechanical compliance and degradation rate that meet the requirements of soft tissue engineering. In this work, we have synthesised a new PGS nanocomposite ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.05.038
更新日期：2011-11-01 00:00:00
abstract：:In total hip replacement (THR), wear particles play a significant role in osteolysis and have been observed in locations as remote as the tip of femoral stem. However, there is no clear understanding of the factors and mechanisms causing, or contributing to particle migration to the periprosthetic tissue. Interfacial ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.01.005
更新日期：2014-04-01 00:00:00
abstract：:One of the most important alterations that occur in man and experimental animals during spaceflight concerns the skeletal system, and entails important bone loss and degradation of mechanical properties. In the present work we investigate ex vivo the long-term effects of weightlessness (simulated microgravity) on bone...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.01.002
更新日期：2015-04-01 00:00:00
abstract：:Titanium alloys (Ti-6Al-4V) are promising materials as bone implants in clinical surgeries owing to their excellent performances. However, wear debris caused by the tribological behavior of the cortical bone and titanium alloy interface were found to be paramount for implant stability. The contact environment between ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.10.031
更新日期：2019-02-01 00:00:00
