Abstract:
:Characterization of the mechanical properties of biological materials is often complicated by small volume, irregular geometry, fragility, and environmental sensitivity. Pipette aspiration and nanoindentation testing deal well with these limitations and have seen increasing use in biomaterial characterization, but little research has been done to systematically validate these techniques for soft materials. This study compared the results of pipette aspiration, nanoindentation, and bulk uniaxial tension and compression in determining the small-strain elastic moduli of a range of biomedically-relevant materials, a series of silicone elastomers and polyacrylamide hydrogels. A custom apparatus was developed for pipette aspiration testing, a commercial Hysitron instrument with custom spherical tip was used for nanoindentation, and standard commercial machines were used for tension and compression testing. The measured small-strain elastic moduli ranged from 27 to 368 kPa for the silicones and 11 to 44 kPa for the polyacrylamide gels. All methods detected expected trends in material stiffness, except for the results from one inconsistent silicone. Pipette aspiration and nanoindentation measured similar elastic moduli for silicone materials, but pipette aspiration measured consistently larger stiffness in the hydrogels, which may be explained by the gels' resistance to tension. Despite the difference in size scale among the testing methods, size does not appear to influence the results. These results suggest that both pipette aspiration and nanoindentation are suitable for measuring mechanical properties of soft biomaterials and appear to have no more limitations than bulk techniques.
journal_name
J Mech Behav Biomed Materauthors
Buffinton CM,Tong KJ,Blaho RA,Buffinton EM,Ebenstein DMdoi
10.1016/j.jmbbm.2015.07.022subject
Has Abstractpub_date
2015-11-01 00:00:00pages
367-79eissn
1751-6161issn
1878-0180pii
S1751-6161(15)00263-5journal_volume
51pub_type
杂志文章abstract::Fibrin sealant (FS) is a biomaterial that exhibits hemostatic and repairing properties. It has been successfully used as scaffolds and adhesives to improve repair and regeneration of tissues. The objective of this study was to evaluate the effect of FS in the regeneration process of bone defects in male rat tibias thr...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2020.103662
更新日期:2020-04-01 00:00:00
abstract::The use of an adhesive for mesh fixation in hernia repair reduces chronic pain and minimizes tissue damage in the patient. This study was designed to assess the adhesive properties of a medium-chain (n-butyl) cyanoacrylate glue applied as drops or as a spray in a biomechanical and histologic study. Both forms of glue ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.08.008
更新日期:2017-11-01 00:00:00
abstract::Microinjection is a widely used technique to deliver foreign materials into biological cells. We propose a mathematical model to study the mechanical behavior of a cell in microinjection. Firstly, a cell is modeled by a hyperelastic membrane and interior cytoplasm. Then, based on the fact that the equilibrium configur...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.04.017
更新日期:2013-08-01 00:00:00
abstract::The medial patello-femoral ligament is considered the most important passive patellar stabilizer and its proper functionality is essential for the patello-femoral joint stability. In this work, 18 human knees were randomly divided into two groups and reconstructed through two different surgical techniques: the "Throug...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.02.009
更新日期:2016-06-01 00:00:00
abstract::Many treatments for cardiovascular diseases include an endovascular insertion of stents or stent grafts into arteries, a procedure which may cause high tissue stresses and even damage in the arterial wall. In order to study such problems by using finite element methods, both appropriate constitutive models and experim...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2012.03.012
更新日期:2012-08-01 00:00:00
abstract::This paper presents an improved identification method of the constitutive properties of lung parenchyma. We aim to determine the non-linear viscoelastic behavior of lung parenchyma with a particular focus on the compressible properties - i.e. the ability to change volume. Uniaxial tensile tests are performed on living...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.09.018
更新日期:2014-01-01 00:00:00
abstract::Clinical meshes used in pelvic organ prolapse (POP) repair are predominantly manufactured from monofilament polypropylene (PP). Complications from the use of these meshes in transvaginal kits, including mesh exposure and pain, have prompted two public health notifications by the FDA. The aim of this study was to compa...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.04.002
更新日期:2013-07-01 00:00:00
abstract::Many biomineralized organisms have evolved highly oriented nanostructures to perform specific functions. One key example is the abrasion-resistant rod-like microstructure found in the radular teeth of Chitons (Cryptochiton stelleri), a large mollusk. The teeth consist of a soft core and a hard shell that is abrasion r...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.03.026
更新日期:2015-08-01 00:00:00
abstract::The mechanical reliability of calcium phosphate cements has restricted their clinical application in load-bearing locations. Although their mechanical strength can be improved using a variety of strategies, their fatigue properties are still unclear, especially after degradation. The evolutions of uniaxial compressive...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.07.026
更新日期:2017-11-01 00:00:00
abstract::In the study, CoCrWCu alloys with differing Cu content (2, 3, 4 wt%) were prepared by selective laser melting using mixture powders consisting of CoCrW and Cu, aiming at investigating the effect of Cu on the microstructures, mechanical properties, corrosion behavior and cytotoxicity. The SEM observations indicated tha...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.02.026
更新日期:2018-05-01 00:00:00
abstract::Osteoporosis can lead to bone compressive fractures in the lower lumbar vertebrae. In order to assess the recovery of vertebral strength during drug treatment for osteoporosis, it is necessary not only to measure the bone mass but also to perform patient-specific mechanical analyses, since the strength of osteoporotic...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2009.03.001
更新日期:2010-01-01 00:00:00
abstract::In the present work, we propose the first structural constitutive model of the passive mechanical behavior of the swine colon that is validated against physiological inflation-extension tests, and accounts for residual strains. Sections from the spiral colon and the descending colon were considered to investigate pote...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.08.031
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to evaluate if mechanical cycling influences bioactivity and bond strength of resin-dentine interface after bonding with Zn-doped self-etching adhesives. Sound dentine surfaces were bonded with Clearfil SE Bond (SEB), 10 wt% ZnO microparticles or 2 wt% ZnCl2 were added into the SEB primer (P)...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.05.026
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Bacterial contamination of breast implants and biofilm formation has been discussed as a major reason for implant loss and capsular contraction. Intra- and perioperative treatment of breast implants with disinfectants to prevent bacterial contamination has been frequently reported. Given the increasing aware...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.10.021
更新日期:2019-02-01 00:00:00
abstract::Advances in adhesive technologies have increased indications for the use of inlays. Decrease in the bonded interface integrity due to wear has been cited as the main cause of its failure. However, this process of interface degradation and the influence of inlay material on damage mechanism appear to be poorly understo...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.103430
更新日期:2020-01-01 00:00:00
abstract::In this study, the relationship between deformation mechanism and rolling reductions was investigated, and the effects of deformation reductions on the microstructure and mechanical properties of the alloys both cold rolled and aged were revealed. It was found that the equiaxed β grains of the Ti-30Nb-5Ta-6Zr alloy ha...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.06.006
更新日期:2013-11-01 00:00:00
abstract::There are several studies dealing with experimental and structural analyses of skeletal muscles that are aimed at gaining a better understanding of three-dimensional muscle deformation and force generation. A variety of these contributions have performed structural or mechanical analyses, but very few have combined th...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.06.026
更新日期:2015-11-01 00:00:00
abstract::Mechanical characterization of the cortex of rectrices (tail feathers) of the Toco Toucan (Ramphastos toco) has been carried out by tensile testing of the rachis cortex in order to systematically determine Young's modulus and maximum tensile strength gradients on the surfaces and along the length of the feather. Of ov...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2011.01.010
更新日期:2011-07-01 00:00:00
abstract::The tension-compression switch hypothesis for soft tissue proposes that when collagen fibres are compressed they do not contribute to the mechanical response which is then assumed to be the isotropic response of the extra-cellular matrix in which they are embedded. Such an assumption would seem reasonable. However, th...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.103558
更新日期:2020-03-01 00:00:00
abstract::Crosslinked Ultra High Molecular Weight Polyethylene (UHMWPE), which is used as a bearing material in total joint replacement components, is subjected to static and cyclic loads in vivo. Resistance to crack initiation from a notch as a function of static and cyclic loads is not well understood for crosslinked UHMWPE. ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.12.032
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND AND AIMS:The course and outcome of pregnancy is closely correlated to change of biomechanical properties of the uterine cervix. The aim of this study was to build a non-linear, fiber reinforced mechanical model of the cervix for estimation of mechanical characteristics of the cervix in early- and term-pregna...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.07.005
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the interfacial adhesion of an autopolymerizing acrylic resin to 3D printed thermoset occlusal splints compared to thermoplastic occlusal splints. MATERIALS AND METHODS:Cylinders made of an autopolymerizing acrylic resin were adhered to 3D printed thermoset and also to thermoplastic plates. A di...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.04.011
更新日期:2019-07-01 00:00:00
abstract::CAD/CAM restorations can be produced from several ceramic and hybrid materials. The moderate mechanical properties of PMMA based resin have hindered its use for permanent restorations. Recently, a graphene reinforced PMMA namely G-CAM has been introduced for permanent CAD/CAM restorations. Although graphene family mat...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.103388
更新日期:2019-12-01 00:00:00
abstract::Hydrogels are more and more attractive in biomedical fields, since they can be used as injectable scaffolds, drugs and gene carriers and smart sensors. The highly hydrated hydrogels, however, generally have low mechanical strength. In this work, a composite chitosan hydrogel was prepared by blending water soluble and ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2008.02.001
更新日期:2008-10-01 00:00:00
abstract::Although clinical bone fractures occur predominantly under impact loading (as occurs during sporting accidents, falls, high-speed impacts or other catastrophic events), experimentally validated studies on the dynamic fracture behavior of bone, at the loading rates associated with such events, remain limited. In this s...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2010.09.006
更新日期:2011-01-01 00:00:00
abstract::When bone implants are loaded, they are inevitably subjected to displacement relative to bone. Such micromotion generates stress/strain states at the interface that can cause beneficial or detrimental sequels. The objective of this study is to better understand the mechanobiology of bone healing at the tissue-implant ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.05.044
更新日期:2018-09-01 00:00:00
abstract::Titanium and its alloys are common biomedical materials owing to their combination of mechanical properties, corrosion resistance and biocompatibility. Powder metallurgy (PM) techniques can be used to fabricate biomaterials with tailored properties because changing the processing parameters, such as the sintering temp...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.12.005
更新日期:2017-03-01 00:00:00
abstract::The aim of the presented study was to estimate the material properties of human patellar ligaments from the elderly population by means of tensile tests. The experimental part was conducted on a custom tensile-testing device, with a built-in enclosure to simulate in-vivo conditions, using 25 (15 female, 10 male) bone-...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2020.103994
更新日期:2020-10-01 00:00:00
abstract::Poly(vinyl alcohol) (PVA) is reinforced with TiO2 nanoparticles in order to enhance thermo-mechanical stabilities, surface characteristics and osteoblastic cell adhesion. PVA-TiO2 nanocomposite films with desirable mechanical, thermal and biocompatible properties are fabricated through solution casting method followed...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.06.009
更新日期:2016-10-01 00:00:00
abstract::Use of hydroxyapatite (HAP) for biomaterials is widely established, often in a combination with titanium alloy substrates in orthopaedic and other implants. Porous HAP-based coatings undergo sintering and heat treatment processes to achieve proper level of density yet avoiding undesirable reactions and phase changes. ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.11.017
更新日期:2014-02-01 00:00:00