Abstract：
:Hydrogels are more and more attractive in biomedical fields, since they can be used as injectable scaffolds, drugs and gene carriers and smart sensors. The highly hydrated hydrogels, however, generally have low mechanical strength. In this work, a composite chitosan hydrogel was prepared by blending water soluble and crosslinkable chitosan derivative (CML) with poly(lactic-co-glycolic acid) (PLGA) particles whose surfaces were grafted with double carbon bonds containing gelatin (GM), following gelation under UV irradiation. The as-prepared composite hydrogel showed lower swelling ratio than that of the CML hydrogel, and higher elastic stiffness (i.e. storage modulus) than that of the CML hydrogel and the hydrogel filled with the same amount of PLGA particles or gelatin modified PLGA particles. Moreover, the storage modulus of the composite hydrogel was increased with the amount of GM modified PLGA particles. In vitro chondrocyte culture revealed that viability of the cells co-cultured with the GM modified PLGA particles was higher than that of the cells co-cultured with the unmodified PLGA particles. The composite hydrogel blended with the GM modified PLGA particles also showed higher cytoviability than that of the original CML hydrogel after 9d culture.
journal_name
J Mech Behav Biomed Materauthors
Hu X,Zhou J,Zhang N,Tan H,Gao Cdoi
10.1016/j.jmbbm.2008.02.001subject
Has Abstractpub_date
2008-10-01 00:00:00pages
352-9issue
4eissn
1751-6161issn
1878-0180pii
S1751-6161(08)00022-2journal_volume
1pub_type
杂志文章abstract：OBJECTIVE:To introduce an experimental non-carious cervical lesion (NCCL) model for studying the influence of presence and type of stress (tension or compression) on acid effects involved in NCCL formation on the enamel near the cement-enamel junction (CEJ). METHODS:108 bovine incisors were cut into 18 × 3×3 mm3 beams...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.11.003
更新日期：2017-02-01 00:00:00
abstract：:An optimized thickness of a transplantable auricular silicone scaffold was researched. The original image data were acquired from CT scans, and reverse modeling technology was used to build a digital 3D model of an auricle. The transplant process was simulated in ANSYS Workbench by finite element analysis (FEA), solid...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.08.032
更新日期：2016-01-01 00:00:00
abstract：:Bone derives its mechanical strength from the complex arrangement of collagen fibrils (type-I primarily) reinforced with hydroxy-apatite (HAp) mineral crystals in extra- and intra-fibrillar compartments. This study demonstrates a novel approach to obtain organic matrix of bone through its demineralization as well as m...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.12.031
更新日期：2019-03-01 00:00:00
abstract：:Total knee replacement implants consisting of a Co-29Cr-6Mo alloy femoral component and a Ti-6Al-4V tibial component are the basis for the additive manufacturing of novel solid, mesh, and foam monoliths using electron beam melting (EBM). Ti-6Al-4V solid prototype microstructures were primarily α-phase acicular platele...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.05.010
更新日期：2011-10-01 00:00:00
abstract：:The shape memory effect (SME) has long been the focus of interest of many research groups that have studied many facets of it, yet to the authors' knowledge some molecular parameters, such as the molecular weight, have been skipped. Thus, the aim of this work is to offer further insight into the shape memory effect, b...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.04.027
更新日期：2016-08-01 00:00:00
abstract：:As a substitute for 2,2-bis[4-(2-hydroxy-3- methacryloxypropoxy)phenyl] propane (Bis-GMA) in dental materials, a new dimethacrylate monomer TDDMMA without bisphenol-A structure was synthesized through the reaction between tricyclo[5.2.1.0(2,6)]- decanedimethanol and 2-isocyanatoethyl methacrylate. The TDDMMA was mixed...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.11.020
更新日期：2016-04-01 00:00:00
abstract：:In this paper, to characterize the mechanical properties of meniscus by considering its local microstructure, a novel nonlinear poroviscoelastic Finite Element (FE) model has been developed. To obtain the mechanical response of meniscus, indentation experiments were performed on bovine meniscus samples. The ramp-relax...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.09.023
更新日期：2018-01-01 00:00:00
abstract：:Ni-free Co-Cr-Mo alloys are some of the most difficult-to-work metallic materials used commonly in biomedical applications. Since the difficulty in plastically deforming them limits their use, an in-depth understanding of their plastic deformability is of crucial importance for both academic and practical purposes. In...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.10.021
更新日期：2015-03-01 00:00:00
abstract：:Proper statistical analysis is essential in the research studies. In particular, as regards the in vitro testing of the lumbar spine, the criteria for the standardization have been extensively discussed but the use of statistics has not been reviewed. Unfortunately, cadaveric testing is a very difficult and complex ex...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103862
更新日期：2020-10-01 00:00:00
abstract：:Haversian remodeling is known to result in improved resistance to compressive fracture in healthy cortical bone. Here, we examine the individual roles of the mean porosity, structure of the network of pores and remodeled bone matrix properties in the fracture behavior of Haversian bone. The detailed structure of poros...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.04.013
更新日期：2018-07-01 00:00:00
abstract：:This paper presents a strain-based damage model to predict the stress-strain relationship and investigate the damage onset and evolution of the fibre and matrix of a fully bio-resorbable phosphate glass fibre reinforced composite under three-point bending. The flexural properties of the composite are crucial, particul...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.02.022
更新日期：2018-05-01 00:00:00
abstract：:As a mechanoactive tissue, articular cartilage undergoes compression and shear on a daily basis. With the advent of high resolution and sensitive mechanical testing methods, such as micro- and nanoindentation, it has become possible to assess changes in small-scale mechanical properties due to compression and shear of...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.104113
更新日期：2021-01-01 00:00:00
abstract：:The elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.11.010
更新日期：2012-04-01 00:00:00
abstract：:Imprecise knowledge on the composition-processing-microstructure-property correlation of titanium alloys combined with experimental data are used for developing rule based models for predicting the strength and elastic modulus of titanium alloys. The developed models are used for designing alloys suitable for orthoped...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.08.039
更新日期：2016-01-01 00:00:00
abstract：:Pressure ulcers (PUs) are common in patients who chronically depend on a wheelchair for mobility, such as those with a spinal cord injury (SCI). In attempt to prevent the formation of PUs, pressure relieving maneuvers, such as push-ups, are commonly recommended for individuals with SCI. However, very little is known a...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.04.015
更新日期：2013-12-01 00:00:00
abstract：:Fourier Transform Raman Spectroscopy was used to investigate the molecular changes of structural proteins in human skin subjected to strain. In the Raman spectrum of unstrained skin, bands assigned mainly to collagen and elastin were observed at 1658 cm(-1) (amide I), 1271 and 1255 cm(-1) (amide III), and 935 and 817 ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.11.023
更新日期：2013-02-01 00:00:00
abstract：:Despite the great potential of Mg and its alloys as material for biodegradable implants, their low resistance to the simultaneous action of corrosion and mechanical stresses in the human body have hampered their use. Stress Corrosion Cracking has been reported as one of the most critical failure modes to overcome to a...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103724
更新日期：2020-06-01 00:00:00
abstract：:Tissue nonlinearity is conventionally measured in shear wave elastography by studying the change in wave speed caused by the tissue deformation, generally known as the acoustoelastic effect. However, these measurements have mainly focused on the excitation and detection of one specific shear mode, while it is theoreti...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103754
更新日期：2020-07-01 00:00:00
abstract：:Cell seeding of 3D scaffolds is a critical step in tissue engineering since the final tissue properties are related to the initial cell distribution and density within the scaffold unit. Perfusion systems can transport cells to the scaffold however; the fact that cells flow inside the scaffold pores does not guarantee...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.08.003
更新日期：2017-11-01 00:00:00
abstract：:Continuous fibre distribution models can be applied to a variety of biological tissues with both charged and neutral extracellular matrices. In particular, ellipsoidal models have been used to describe the complex material behaviour of tissues such as articular cartilage and their engineered tissue equivalents. The ch...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.01.006
更新日期：2012-05-01 00:00:00
abstract：:The hierarchical architecture of the collagen fibril is well understood, involving non-integer staggering of collagen molecules which results in a 67 nm periodic molecular density variation termed D-banding. Other than this variation, collagen fibrils are considered to be homogeneous at the micro-scale and beyond. Int...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103849
更新日期：2020-10-01 00:00:00
abstract：:The use of highly sensitive soft materials has become increasingly apparent in the last few years in numerous industrial fields, due to their viscous and damping nature. Unfortunately these materials remain difficult to characterize using conventional techniques, mainly because of the very low internal forces supporte...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.06.008
更新日期：2016-10-01 00:00:00
abstract：:Cell mechanics plays an important role in regulating the physiological activities of cells. The advent of atomic force microscopy (AFM) provides a novel powerful instrument for quantifying the mechanics of single cells at the nanoscale. The applications of AFM in single-cell mechanical assays in the past decade have s...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.03.036
更新日期：2018-06-01 00:00:00
abstract：:Main objective of this study is to investigate the thermal behavior of ceramic laminate veneer restorations of the maxillary central incisor with different incisal preparations such as butt joint and palatinal chamfer using finite element method. In addition, it is also aimed to understand the effect of different ther...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.07.039
更新日期：2017-11-01 00:00:00
abstract：:With the growing attention on estrogenic effect of Bisphenol A (BPA), the application of BPA derivatives like Bis-GMA in dental materials has also been doubted. In this research, new BPA free dental resin systems were prepared with synthesized dendritic macromer G-IEMA, UDMA, and TEGDMA. Physicochemical properties, su...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.03.012
更新日期：2014-07-01 00:00:00
abstract：:Polylactic acid (PLA), one of the most likely green and environmentally friendly materials, is an alternative to petroleum-based plastic. It still remains a challenge to increase the degradation rate and decrease the cost of PLA without compromised mechanical properties. Low cost PLA/wood flour (WF) composite was elab...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.08.016
更新日期：2018-12-01 00:00:00
abstract：:Silver nanoparticles embedded within a nanofibrous polymer matrix have significant attention in recent years as an antimicrobial wound dressing materials. Herein, we have fabricated a novel Ag-polyurethane-zein hybrid nanofibrous scaffold for wound dressing applications. AgNPs were synthesized in-situ via reduction of...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.07.034
更新日期：2017-01-01 00:00:00
abstract：:The arterial wall is a composite where the preferred orientation of collagen fibers induces anisotropy. Though the hyperelastic theories of fiber-reinforced composites reached a high level of sophistication and showed a reasonable correspondence with the available experimental data they are short of the failure descri...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.01.002
更新日期：2011-11-01 00:00:00
abstract：:In this study, the fabrication and properties of a synthetic keratoprosthesis skirt for use in osteo-odonto-keratoprosthesis (OOKP) surgery are discussed. In the search for a new material concept, bioactive glass and polymethyl methacrylate (PMMA)-based composites were prepared. Three different bioactive glasses (i.e....
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.05.025
更新日期：2011-11-01 00:00:00
abstract：:The lumbar facet capsular ligament (FCL) articulates with six degrees of freedom during spinal motions of flexion/extension, lateral bending, and axial rotation. The lumbar FCL is composed of highly aligned collagen fiber bundles on the posterior surface (oriented primarily laterally between the rigid articular facets...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.08.019
更新日期：2017-01-01 00:00:00
